1.Impact of diversity care on mental state of self-management ability of patients with gastric cancer
Zhonghui LIU ; Jinyan SUN ; Shuxia ZHANG ; Yingjuan CAI
Journal of Clinical Medicine in Practice 2017;21(2):37-39
Objective To analyze impact of diversity care on mental state of self-management ability of patients with gastric cancer.Methods A total of 85 patients with gastric cancer in our hospital were divided into two groups according to the random principle.The control group was taken routine care and the observation group accepted diversity nursing on the basis of traditional way.Psychological state,self-management skills,and satisfaction were observed and analyzed.Results The scores of depression,fear,and anxiety were significantly lower than the control group (P < 0.05).Before nursing,no significant difference was seen in self-management ability in the observation group compared with the control group (P > 0.05),while after treatment it was significantly higher than the control group (P < 0.05).The satisfaction in the observation group was significantly higher than that in the control group,the difference was statistically significant (P < 0.05).Conclusion Compared to traditional care measures,the diversity care can effectively improve emotions and quality of life of patients with gastric cancer,and enhance the patient's self-management skills,so it is worthy of widely clinical practice.
2.Impact of diversity care on mental state of self-management ability of patients with gastric cancer
Zhonghui LIU ; Jinyan SUN ; Shuxia ZHANG ; Yingjuan CAI
Journal of Clinical Medicine in Practice 2017;21(2):37-39
Objective To analyze impact of diversity care on mental state of self-management ability of patients with gastric cancer.Methods A total of 85 patients with gastric cancer in our hospital were divided into two groups according to the random principle.The control group was taken routine care and the observation group accepted diversity nursing on the basis of traditional way.Psychological state,self-management skills,and satisfaction were observed and analyzed.Results The scores of depression,fear,and anxiety were significantly lower than the control group (P < 0.05).Before nursing,no significant difference was seen in self-management ability in the observation group compared with the control group (P > 0.05),while after treatment it was significantly higher than the control group (P < 0.05).The satisfaction in the observation group was significantly higher than that in the control group,the difference was statistically significant (P < 0.05).Conclusion Compared to traditional care measures,the diversity care can effectively improve emotions and quality of life of patients with gastric cancer,and enhance the patient's self-management skills,so it is worthy of widely clinical practice.
3.Research on dynamic visual function difference
Jun CAI ; Dawei TIAN ; Po XU ; Yange ZHANG ; Qingjun ZHANG ; Xiaoyang YANG ; Yongsheng CHEN ; Lei SONE ; Mei LONG ; Yingjuan ZHENG ; Yuanyuan JIANG ; Shan CHEN ; Sujiang XIE ; Hongbo JIA ; Jie WANG
Military Medical Sciences 2014;(5):368-370
Objective To detect the dynamic visual acuity ( DVA) before and after vestibular habituation of subjects in order to optimize the DVA assessment criteria .Methods The vestibular function examination system was applied to the detection of static and dynamic visual function in 16 healthy subjects .Results When the speed of left or right swinging was fast enough , DVA before and after vestibular habituation was different .Conclusion Subjects with vestibular habituation can reduce their sensitivity to the vestibular system , the changes in DVA are better than before habituation , and the vestib-ular function adaptability training may have effect on DVA .
4.C0818, a novel curcumin derivative, interacts with Hsp90 and inhibits Hsp90 ATPase activity.
Yingjuan FAN ; Yang LIU ; Lianru ZHANG ; Fang CAI ; Liping ZHU ; Jianhua XU ;
Acta Pharmaceutica Sinica B 2017;7(1):91-96
The aims of the present study were to estimate the affinity between 3,5-()-bis(3-methoxy-4-hydroxybenzal)-4-piperidinone hydrochloride (C0818) and heat shock protein 90 (Hsp90) and to investigate the inhibitory effects of this compound on Hsp90 ATPase activity. Fluorescence spectroscopy was used to examine the affinity between varying concentrations of C0818 and Hsp90, N-Hsp90, M-Hsp90 and C-Hsp90. Fluorescence intensities were recorded in the range of 290-510 nm at 293, 303 and 310 K, respectively. A colorimetric assay for inorganic phosphate (based on the formation of a phosphomolybdate complex and the subsequent reaction with malachite green) were used to examine the inhibitory effects of C0818 on Hsp90 ATPase activity. The equilibrium dissociation constantvalue of C0818 was found to be 23.412±0.943 μmol/L. The interaction between C0818 and Hsp90 was driven mainly by electrostatic interactions. C0818 showed the strongest affinity with C-Hsp90. These results conclusively demonstrate the inhibitory activity of C0818 on the activity of Hsp90 ATPase.