White matter injury and abnormal maturation are thought to be major contributors to the neurodevelopmental disabilities observed in children and adolescents who are born preterm. By using water molecules diffuse technology, diffuse tensor imaging can assess the features of white matter maturation, at the same time, it can reveal the types and mechanisms of cerebral white matter injury.

Objective To explore the risk factors of fungal lung infection in the elderly.Methods A retrospective analysis was carried out in 60 elderly patients with fungal lung infection admitted by Gulou Hospital Affiliated to Medial College of Nanjing University.The pathogenic bacteria and risk factors of fungal lung infection in the elderly were investigated.Results Candida albicans was the main pathogenic bacteria of fungal lung infection in the elderly,and the onset of fungal lung infection was probably related with the following factors: the existence of chronic background diseases,the application of antibiotics,hypoproteinemia,and the application of glucocorticoids.Conclusion Candida albicans is the main pathogenic bacteria of fungal lung infection in the elderly,and the existence of chronic background diseases,the application of antibiotics,hypoproteinemia and the application of glucocorticoids may be the independent risk factors of fungal lung infection in the elderly.Chinese medicine shows advantages for the treatment of fungal lung infection in the elderly.

0.05),but the difference of serum low density lipoprotein cholesterol(LDL-C),glucose(Glu)and uric acid(UA)levels was significant(P

As a classical problem of computational molecular biology, the multiple sequences alignment is also important foundational process. RNA is one of biological polymer, and is different from protein and DNA that the secondary structure of RNA is more conservative than its primary sequence. Therefore, RNA multiple sequences alignment require not only information of sequences, but also information of secondary structures which those sequences will form. Here, a program——QEA-MRNA, which based on quantum evolutionary algorithm(QEA) to align RNA sequences, is proposed. The program introduce a full crossover operator and a fitness function which considering the information of RNA premary sequence and secondary structure, and improving on prematurity controling and the convergent speed. The effectiveness and performance of QEA-MRNA are demonstrated by testing cases in BRAliBase.

ObjectiveTo observe the clinical efficacy of superficial needling in treating senile intractable constipation.Method The recruited patients were randomized into a treatment group and a control group, 40 in each group. The treatment group was intervenedby superficial needling, while the control group was by oral administration of Phenolphthalein tablets. The two groups both received the treatments for 4 weeks.ResultThe therapeutic efficacy increased with the treatment; patients showed improvements indefecation frequency, stool constitution, and effort in defecation (P<0.05); there was a significant difference between the treatment group and the control group (P<0.05); the residual marker counts of 48 h and 72 h after treatment were significantly lowered in both groups compared to that before treatment (P<0.05).ConclusionSuperficial needling can obviously improve the symptoms of senile intractable constipation, promoting the gastrointestinal transit motility.

The study was undertaken to ascertain the effects of C2 on he- patic lipase(HL), lipoprotein lipase ( LPL ) and plasma lipids. It was found that HDL-c and HDL-c /TC were increased, but(VLDL + LDL)-c and TC were decreased. LPL activety was positively correlated with the increase of HDL-c and the decrease of ( VLDL+LDL )-c.

Objective To investigate the correlation between the arterial compliance and insulin resistance in the prehypertensive people.Methods 30 healthy persons,36 prehypertensive persons and 46 hypertensive patients were measured Cl and C2 using CVProfilor DO-2020 and determined insulin sensitivity with HOMA-IR.Results Adjusted for the age and the course of disease,C1 and C2 decreased in hypertensive patients compared with that of the healthy and prehypertensive people(P<0.05);C2 decreased in prehypertensive people compared with the healthy groups(P<0.05).HOMA-IR increased in hypertensive patients and prehypertensive people compared with the healthy groups(P<0.05).There was significant correlation between HOMA-IR and C2 in prehypertensive people.Conclusion Small arterial compliance decrease and insulin resistance can be found with negatively correlation in prehypertensive people.

OBJECTIVE:To develop a method for determining the entrapment efficiency of tetracaine hydrochloride liposome.METHODS:The microcolumn centrifugation was adopted to separate the free tetracaine hydrochloride from liposomes;the content of tetracaine hydrochloride was determined by HPLC and the entrapment efficiency was computed.RESULTS:By microcolumn centrifugation,the liposomes and the free tetracaine hydrochloride were well-separated.The recovery rate of the blank liposomes was 90.4%～100.1%;the absorption rate of free tetracaine hydrochloride was 96.6%～99.2%;and the entrapment efficiencies of tetracaine liposomes stood at about 80%.CONCLUSION:This method established for determining the entrapment efficiency of tetracaine hydrochloride liposome is simple,rapid and reproducible.

Objective To study patients experience in and needs for vaginal douching in the department of gynecology.Method Using semi-structured interviews,10 patients undergoing vaginal douching in the hospital were selected,and then the interviews were analyzed and described with the content analysis method.Results Before vaginal douching,the patients had some psychological states of tension,fear,shyness,fear and calmness.In the process of vaginal douching,the patients experienced comforts,pain,fear,shyness and dissatisfaction with water temperature and skin preparation.After vaginal douching,the patients experienced worries of different sorts like vaginal infections,sexual life and pregnancy.The patients needed for the douching-related knowledge and the improvement in hygienic situations and they had some questions about urination and defection,operative effect and bathing and infection.Conclusion Medical staff should provide the corresponding services for patients during vaginal douching according to their needs and individual situations so as to enhance the nursing service quality.

Objective To evaluate the efficacy of a new hybrid bioartificial liver support system in the treatment of severe viral hepatitis. Methods A hybrid liver support system consisting of plasma exchange device, plasma perfusion column (charcoal) and a hollow fiber reactor inoculated with 1?10 9 aggregated human hepatocytes or porcine hepatocytes was developed. Ten patients with severe viral hepatitis were treated using this hybrid system. Results The effective rate of the hybrid bioartificial liver support system was 70% (7/10). The mental status and signs of toxicity of patients were improved markedly. Two patients of coma Ⅲ woke up and grade Ⅱ encephalopathy in 4 patients disappeared after treatment. At the same time, a marked decrease in total serum bilirubin and prothrombin time was noted after treatment. Finally, Three out of 10 patients recovered completely. Two patients were bridged to liver transplantation. Five patients died from the complication of hepatic failure or discharge refused advice due to worsening of disease.Conclusions The evident clinical improvement shows that this artifical liver system has prominant liver support effects for the patients with severe viral hepatitis and liver failure.