Objective To investigate the relationship between herpes simplex virus(HSV) and spontaneous abortion. Methods 40 aborted material and 16 post-aborted curettings were tested for the presence of HSVDNA with in situ hybridization.In addition 20 normal endometria and 20 induced abortive placentas were used as controls. Results 56.3 %(9/16)post-abortion curettings were demonstrated the presence of HSVDNA.It was higher than that of the control group( P

Objective To improve the diagnosis and treatment of primary adrenocortical carcinoma. Methods Retrospective analysis was performed in clinical data of 16 patients with primary adrenocortical carcinoma. The diagnosis was based on clinical presentations,hormonal studies and imaging. Surgical treatment was underwent on 13 cases. All patients were followed up for 3 to 62 months. Results Of 16 cases,functional tumors were in 8,including Cushing′s syndrome in 5,combination of Cushing′s syndrome and virilization in 2,and hyperaldosteronism in 1. Imaging studies revealed the tumors were 4.8 to 19.5 cm in diameter,average in 7.8 cm. Distant metastasis occurred in 3 cases. Radical surgery was done in 13 cases without distant metastasis,including radical adrenalectomy in 8,adrenalectomy plus nephrectomy in 2,adrenalectomy plus surgical extirpation of intracaval tumor thrombus in 2,and partial resection of the wall of inferior vena cava in 1. Pathologic stages were stage Ⅰ in 2 cases,stage Ⅱ in 8,stage Ⅲ in 3,stage Ⅳ in 3. Among the 11 cases who were treated over 2 years after operation,6 cases were still survival,while 1 case had pulmonary and 1 case had bone metastasis. The other 5 cases survive in average of 26 months. Conclusions Prognosis of primary adrenocortical carcinoma is poor. The keys to early diagnosis are clinical manifestations plus imaging. Surgical treatment is the only effective therapy for the disease.

Objective To investigate the association of bacterial translocation (BT) with cachexia in colonic cancer patients.Methods From September 2015 to May 2017 the clinical data of 292 colon cancer patients were studied at Qingdao Municipal Hospital.The bacteria in peripheral blood and mesenteric lymph nodes were detected by bacterial culture,and the bacterial DNA in peripheral blood was detected by PCR technique to determine the occurrence of bacterial translocation.Intestinal epithelial T-cell subsets and NK cells were evaluated using flow cytometry.Western blot and immunofluorescence were used to check tight junction proteins Occludin,Claudins-2,Zonula occluden-2 in intestinal epithelium.Fluorescence in situ hybridization and immunohistochemistry were used to detect the translocated bacteria and endotoxin.Results Compared with noncachectic patients,cachectic patients had a significandy higher BT ratio (27.8％ vs.7.2％,x2 =20.871,P ＜ 0.001).BT in the intestinal mucus layer was associated with lower levels of T-cell subsets and NK cells in the intestinal epithelium in BT(+) patients (CD3 + T:36.69％ ±5.87％ vs.41.63％ ±5.03％,CD4+T:44.08％ ±5.12％ vs.49.58％ ±7.01％,CD8+T:65.68％ ±5.51％ vs.61.43％ ± 5.58％,CD4+ T/CD8+ T:0.71％ ± 0.21％ vs.0.91％ ±0.23％,NK:27.86％ ± 3.93％ vs.34.69％ ± 4.52％,all P ＜ 0.01).Endotoxin was detected within the small intestinal wall in BT(+) patients and claudin-2 expression increased (0.63 ± 0.13 vs.0.21-± 0.06,t =-2.936,P ＜ 0.01),whereas Occludin and Zonula occluden-2 expressions decreased (0.37 ± 0.13 vs.0.84±0.17,0.16±0.07 vs.0.58±0.19,t=2.151,2.111,bothP＜0.05).Conclusions BTmay contribute to the development of colon cancer cacheria,and tight junction could be the gateway of BT.

Objective: To understand the cognitive and management status of breast cancer patients with expectant nausea and vomiting in breast cancer patients, and to provide reference for taking targeted measures to improve the symptoms of nausea and vomiting. Methods: From March to May 2018, 10 breast surgical nurses were selected by the purpose sampling method. The phenomenological research methods in qualitative research were used to interview them. The Colaizzi data analysis principle was used to analyze the data and refine the theme. Results: A total of five themes were extracted: nurses generally knew the impact of nausea and vomiting on patients; lack of knowledge about the expected nausea and vomiting of chemotherapy; nausea and vomiting has not been evaluated as an independent symptom; there is still no targeted, systematic management Measures; lack of attention is a major obstacle to the management of nausea and vomiting in patients. Conclusion Nurses should strengthen the knowledge of chemotherapy-predicted nausea and vomiting in breast cancer patients, and effectively evaluate patients with nausea and vomiting. Nursing managers should formulate corresponding standardized interventions to improve patients' nausea and vomiting according to the existing problems. Improve the quality of life of patients.

Objective: To evaluate the effects of continued acceptance and commitment therapy intervention on post-traumatic growth of postoperative patients with breast cancer. Methods: According to the hospitalization time, 120 patients with breast cancer were divided into observation group (62 cases) and control group (58 cases). From January to December 2017, 58 patients were used as control group. Regular health education and discharge follow-up were performed. Intervention with the commitment therapy 3 times; 62 patients from January to December 2018 were selected as the observation group. On the basis of the control group, the patient continued to receive and commit the intervention for 3 to 4 times from February to March after discharge. The post-traumatic growth status of patients before, at the time of discharge (after the intervention), at the hospital for 2 months, at the hospital for 3 months, and at the hospital for 6 months was assessed using the Simplified Chinese version of the Post-Treatment Growth Rating Scale (PTGI). Results: There was no significant difference in the post-traumatic growth scores between the two groups (P>0.05). The post-traumatic growth scores of the two groups were 67.02±14.17, 66.93±14.24, which were better than 51.72±11.65, 51.86±11.67 before the intervention (t= 7.634, 7.725, P<0.05). At 3 months and 6 months after discharge, the post-traumatic growth scores of the observation group were (67.12±14.07) and (68.21±14.48), which were significantly better than the control group (54.17±11.64). 54.02±11.12), the difference was statistically significant (t= 7.957, 7.674, P<0.01). Conclusion Acceptance and commitment therapy intervention during hospitalization can effectively improve post-traumatic growth of postoperative patients with breast cancer. Continued admission and commitment therapy intervention after discharge can provide patients with out-of-hospital continuous care programs to improve post-traumatic growth of postoperative patients with breast cancer. It has a better long-term effect than the control group.