Objective To know the influence of intervention on rehaemorrhagia and prognosis of patients with clipping intraerania]aneurysn. Methods Divided 168 patients with clipping intracranial a-neurysm into the observation group (86 cases) and the control group (82 cases) randomly. Perioperative nursing of prospectivity was used in the observation group, while routine nursing cares was used in the con-trol group. Compared the GOS scores and condition of rehaemorrhagia. Results The incidence rate of rehaemorrhagia, cerebral angiospasm, dead and electrolyte disturbances in the observation group was significant lower than those of in the control group, there were 79.1% patients in the observation group had occurred proper rehabilitation, the radio in the control group was 63.4%, the difference was signifi-cant. Conclusions Perioperative nursing of prospectivity can effective avoid certain postoperative com-plicatioas, and then ameliorate the prognosis of patients.

Objective To master the dynamics of schistosomiasis endemic situation and influencing factors in Mianyang City,so as to provide the evidence for making the control and prevention measures. Methods Six villages of six schistosomia?sis heavy endemic counties were selected as survey sites according to the national surveillance protocol(Revision in 2014)in Mianyang City. The surveys of the incidences of schistosomiasis in population and livestock as well as the prevalence of Oncome?lania hupensis snails were conducted in the 6 national surveillance sites. Results The serum positive rates of local residents and migrant people were 2.12%and 1.71%,respectively. The infection rate of cattle was 0. The area with snails was 9.344 8 hm2. The mean density of living snails was 0.25/0.1 m2. The occurrence rate of frames with snails was 7.07%,and no infected snails were found. Conclusions The infection rates of schistosome in human and livestock are low and the prevalence of O. hu?pensis snails is stable in the national surveillance sites in Mianyang City. However,the schistosomiasis transmission risk still ex?ists,therefore,we should strengthen the control measures to prevent the rebound of the endemic.

Objective To explore the recent clinical effects of Xuefuzhuyu Decoction on acute ischemic stroke. Methods 72 patients were randomly divided into treatment group (n=36) and control group (n=36). The control group received routine medicine and Edaravone,and the treatment group received Xuefuzhuyu Decoction in addition, for 14 d. They were assessed with National Institute of Health Stroke Scale (NIHSS), Barthel index (BI) and Traditional Chinese Medicial (TCM) symptom accumulated points. Results The total rate of improvement were 97.22% and 77.78% for the treatment group and the control group respectively, while the rate of very improvement were 80.55% and 50.00% respectively (P<0.05). The scores of NIHSS, BI and TCM symptom accumulated points improved more in the treatment group than in the control group (P<0.001) after the treatment. Conclusion Xuefuzhuyu Decoction is effective on acute ischemic stroke.

Cancer metastasis is considered as a complex process involving a series of sequential steps and a variety of molecalar signal transduction pathways.Tumor recurrence and metastasis are major obstacles for long-term survival of Liver cancer patients.Although the prognosis after recurrence and metastasis is dismal,the advancement of molecular researches of metastasis of liver cancer seems promising.In studies of origins of metastasis of liver cancer,the primary cancer cell and corresponding metastatic liver cancer cells share similar gene signature,which indicates that genes favoring metastasis progression are initiated in the primary tumors.The metastasis of liver cancer may be an early event in hepatic carcinogenesis and progression.Some molecular signatures have been developed to classify the metastatic potential of liver cancer.Furthermore,a variety of studies demonstrate that the tumor microenvironment instead of tumor cells plays a more important role in liver cancer metastasis.The pre-metastatic niche composed of non-tumoral cells may promote the cancer cell sedimentation and progression.The theory of cancer stem cell speculates that cancer stem cells were the real source of recurrent or metastatic tumors.Cancer stem cells will be one of the main targets of liver cancer treatment.The prevention and treatment of liver cancer recurrence or metastasis are quite difficult because liver cancer is resistant to traditional chemotherapy.Targeting the molecules involved in the metastasis of liver cancer WOuld be promising to cure those diseases.

The application of HPLC-NMR-MS hyphenated technique in the structural identification of trace substances from complex mixtures and the identification of endogenous and exogenous substances in the establishment process of metabolic profiling have become effective analytical tools in pharmaceutical chemistry, pharmacological and pharmacokinetic studies of active substances from natural products. Metabolomics method based on NMR technology can accurately portray metabolic phenotypes with the characteristics of diseases and a variety of disease-related pathways, and it can greatly enrich and supplement the traditional disease evaluation methods. So it can be used for pharmacological studies of active substances from natural products, such as toxicological studies, the dose optimization, active substances screening and pharmacodynamic evaluation. Hyphenated technique associated with metabolomics method based on NMR technology will accelerate the speed of the discovery of active substances from natural products, and improve the efficiency of their pharmacological evaluation.

Primary liver cancer is the third most common cause of death from cancer worldwide, and it is the second cause of cancer death in China. A variety of molecular markers and signaling pathways associated with hepatocarcinogenesis and tumor progression have been discovered in basic research in the recent decade. However, the 5 year survival of patients has not been remarkably improved, due in a large part to the late diagnosis and the limited treatment options. It seems that translational medicine should be accelerated to addres this problem. Translational medicine has been shown to bridge basic research and clinical practice in a B2B model: from bench to the bedside and bedside to the bench. It goes from the bench to bedside where theories emerging from preclinical experimentation are tested on patients, and from bedside to the bench, where information obtained from preliminary clinical sciences is used to refine the understanding of the biological principles. In liver cancer, diagnostic markers screening, development of molecular classification, and stratifying patients for targeted therapy are considered as exciting fields of translational medicine. The integration of basic and clinical sciences by translational medicine will improve not only the understanding of the underlying molecular mechanisms, but also the clinical outcomes in patients with primary liver cancer.

The incidence of hepatocellular carcinoma (HCC) has increased worldwide over the past two decades. Surgical resection and liver transplantation have been demonstrated as potentially curative treatment options, which could be considered in 30% -40% of HCC patients. Recent advancements of surgical treatment have focused not only on the surgical techpiques, but also the hepatic functional reserve evaluation, resectability assessment and the effects of biological characteristics of tumor on prognosis. There is no single variable to evaluate the hepatic functional reserve accurately. Combined Child-Pugh classification, ICGI5, portal vein pressure detection and remanent liver volume measurement are required prior to liver resection. The 5-year survival rate after liver resection for HCC is about 50%. The results are acceptable for some selected patients that underwent tumor resection with thrombectomy, including HCC with portal vein tumor thrombus or bile duct thrombosis. The choice of local resection or regular hepatectomy is still controversial although the former is commonly performed to treat HCC with cirrhosis, and the latter is applied to HCC patients without liver cirrhosis. The results of liver transplanta-tion for HCC are better than liver resection, and the Milan criteria is generally accepted. Any attempts to expand the selection criteria should be cautious because of organ shortage. Salvage transplantation for intrabepatic recurrence after liver resection may be a good choice in some resectable HCC. The recurrence and metastasis after surgical treatment are the main obstacles to achieve better results. Identification of predictive factors could be helpful to develop prevention strategies. Due to the importance of biological characteristics in tumor recurrence and metastasis, a molecular classification to predict prognosis of HCC patients will lead to a more personalized medicine. Targeting key molecules of biological pathways could optimize the therapeutic modality in HCC.

Objective To explore the effect of repetitive transcranial magnetic stimulation (rTMS) on motor function in cerebral palsy children with epilepsy. Methods 270 cerebral palsy children with epilepsy hospitalized from February, 2011 to September, 2014 were ran-domized to control group (n=130) and treatment group (n=140). The control group received comprehensive rehabilitation, including mas-sage, exercise, occupational therapy, physiotherapy, speech training, cognitive function training and medication, and the treatment group re-ceived rTMS in addition. They were assessed with Gross Motor Function Measure-88 (GMFM-88) and Peabody Developmental Measure Scale-Gross Motor (PDMS-GM) before, and 1 and 2 months after treatment. Results The total scores of GMFM-88 and PDMS-GM in-creased more in the treatment group than in the control group (F>93.9, P<0.001). Conclusion rTMS can further improve the motor function in cerebral palsy children with epilepsy.

tuftsin,a physiologically active peptide,can promote phagocytosis,basically stimulates the macrophages or neutro-phils and improve their phagocytotic function.tuftsin can not di-rectly kill tumor cells.Due to its short structure and the charac-teristics of being susceptible to hydrolysis,it is difficult for tuft-sin to be made into medicine and applied clinically.However, derivatives of tuftsin-series and combination of tuftsin with other drugs can greatly enhance the cytotoxic effect on tumor cells of tuftsin.It has a broad prospect of research,especially deriva-tive-TP has a significant anti-tumor effect.Its mechanism is clear and its is expected to become a new type of anti-tumor bio-logical response regulator.

OBJECTIVE To search an applicable software in order to achieve real time monitoring and processing management for nosocomial infection which may improve the medical service efficiently through comparing with three different methods.METHODS To analyze and compare the three surveillance methods:the manual summed-up statistical methods,the National Computer Management System for Nosocomial Infection Surveillance Network and the Beijing Information System for Nosocomial Infection Surveillance and Control(Beijing System).RESULTS Beijing System is much more pragmatic and multipurpose than the two others.CONCLUSIONS Beijing System has the feature of wide coverage and convenience manipulating.It is confirmed practical and universal.And it is superexcellent and available for different kinds of hospitals.So Beijing System is worth for being popularized.