Objective To explore the curative effects of artificial skin(hydrocolloid dressing) and erythromycin ointment in the treatment of neonatal skin injury, and to provide theoretical evidences for the promotion of clinically rapid recov-ery of neonatal skin injury and the improvement of curative effects. Methods A total of 160 patients with neonatal skin injury who were treated in our hospital from March 2014 to March 2015 were selected. They were randomly and aver-agely assigned to two groups, research group and control group. Infant patients in the control group were given the treatment of erythromycin ointment, and infant patients in the research group were given the treatment of artificial skin (hydrophilic dressing). Wound healing time, average frequency of dressing change, incidence of complications, non-cure rate and effective rate of treatment were compared between the two groups of infant patients. Results In infant patients of the research group, wound healing time was (4.47±0.76) d, average frequency of dressing change was (3.18±0.52) times, incidence of complications was 5.00%, non-cure rate was 3.75% and effective rate of treatment was 95.00%. All in-dices in the research group were significantly better than those in the control group, and the differences were statisti-cally significant (P<0.05). Conclusion Artificial skin (hydrophilic dressing) in the treatment of neonatal skin injury is able to promote the wound healing rapidly, can reduce the frequency of dressing change and improve the effective rate of treatment.