1.Predictive value of prognostic nutritional index for treatment efficacy and prognosis in locally advanced esophageal squamous cell carcinoma patients treated with chemotherapy combined with immune sequential radiotherapy
WANG Yu1,2 ; WEI Zhuojun2 ; WANG Lin3 ; WANG Ruiqi4 ; CHEN Huan2 ; CHENG Qi2 ; LIN Xiao2 ; MA Honglian2 ; XU Yujin2
Chinese Journal of Cancer Biotherapy 2025;32(4):405-412
[摘 要] 目的:探索预后营养指数(PNI)在接受诱导化疗联合免疫(化免)序贯放疗的局部晚期食管鳞状细胞癌(ESCC)中的疗效预测价值及预后影响。方法: 回顾性分析浙江省肿瘤医院2019年5月至2023年8月期间收治的126例行诱导化免序贯放疗的局部晚期ESCC患者的临床资料。绘制受试者工作特征曲线(ROC曲线),确定患者诱导化免前1周内、放疗前1周内、放疗开始后4 ± 1周的PNI最佳临界值并对患者进行分组。采用Kaplan-Meier法绘制生存曲线,并用Log-Rank法比较组间患者的总生存期(OS)及无进展生存期(PFS),采用Cox回归分析探讨诱导化免序贯放疗的局部晚期ESCC患者的预后影响因素。结果: 共纳入126例局部晚期ESCC患者,男性118例,女性8例,中位年龄65岁(44~78岁)。运用ROC曲线确认的患者诱导化免前、放疗前和放疗中PNI最佳临界值为46.2、48.3和37.9。放疗前PNI ≥ 48.3组中位OS、PFS分别为47.3、28.2个月,放疗前PNI < 48.3组中位OS、PFS分别为18.7、15.2个月(P < 0.01,P < 0.05)。放疗中PNI ≥ 37.9组中位OS未达到,中位PFS为25.7个月,放疗中PNI < 37.9组中位OS、PFS分别为17.0、12.5个月(P < 0.01,P < 0.05)。诱导化免后PNI升高组中位OS未达到,中位PFS为28.4个月;PNI降低组中位OS、PFS分别为20.4、16.0个月(P < 0.01,P < 0.05)。多因素分析显示,放疗中PNI[HR = 2.292,95% CI(1.264,4.159),P < 0.05]、诱导化免后PNI变化[HR = 2.120, 95% CI(1.007, 4.463),P < 0.05]为影响OS因素。结论: 放疗中PNI、诱导化免后PNI变化与患者治疗疗效及预后有一定相关性,可作为预测ESCC化免序贯放疗获益的重要指标。
2.Progress of cellular growth factors in neurorehabilitation and neuroplasticity
Xiaokun LI ; Xu LIU ; Jiahua LIU ; Zhiheng RAO ; Yingde LUO ; Keyang CHEN ; Tong ZHANG
Chinese Journal of Rehabilitation Theory and Practice 2022;28(2):175-182
With potent biological activities, cellular growth factors are polypeptide factors that primarily stimulate cell growth and proliferation. They participate in the regulation of not only normal physiological functions such as human embryonic development and cell growth, but also neurorehabilitation and neuroplasticity in pathological processes such as nerve injury and recovery. Specifically, cellular growth factors have been shown to promote neuron survival, facilitate nerve regeneration and regulate synaptic plasticity, promote cell differentiation/vascular regeneration and modulate the microenvironment, promote nerve fiber myelination and improve nerve conduction. This review summarized current knowledge on the roles and various growth factors in neurorehabilitation and neuroplasticity, providing an update on potential clinical application of cellular growth factors in the field of neural rehabilitation.
3.Near-infrared excited graphene oxide/silver nitrate/chitosan coating for improving antibacterial properties of titanium implants.
Yifan WANG ; Yingde XU ; Xuefeng ZHANG ; Jingyu LIU ; Jintong HAN ; Shengli ZHU ; Yanqin LIANG ; Shuilin WU ; Zhenduo CUI ; Weijia LÜ ; Zhaoyang LI
Chinese Journal of Reparative and Reconstructive Surgery 2023;37(8):937-944
OBJECTIVE:
To design and construct a graphene oxide (GO)/silver nitrate (Ag3PO4)/chitosan (CS) composite coating for rapidly killing bacteria and preventing postoperative infection in implant surgery.
METHODS:
GO/Ag3PO4 composites were prepared by ion exchange method, and CS and GO/Ag3PO4 composites were deposited on medical titanium (Ti) sheets successively. The morphology, physical image, photothermal and photocatalytic ability, antibacterial ability, and adhesion to the matrix of the materials were characterized.
RESULTS:
The GO/Ag3PO4 composites were successfully prepared by ion exchange method and the heterogeneous structure of GO/Ag3PO4 was proved by morphology phase test. The heterogeneous structure formed by Ag3PO4 and GO reduced the band gap from 1.79 eV to 1.39 eV which could be excited by 808 nm near-infrared light. The photothermal and photocatalytic experiments proved that the GO/Ag3PO4/CS coating had excellent photothermal and photodynamic properties. In vitro antibacterial experiments showed that the antibacterial rate of the GO/Ag3PO4/CS composite coating against Staphylococcus aureus reached 99.81% after 20 minutes irradiation with 808 nm near-infrared light. At the same time, the composite coating had excellent light stability, which could provide stable and sustained antibacterial effect.
CONCLUSION
GO/Ag3PO4/CS coating can be excited by 808 nm near infrared light to produce reactive oxygen species, which has excellent antibacterial activity under light.
Chitosan
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Silver Nitrate
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Titanium
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Anti-Bacterial Agents/pharmacology*
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Coloring Agents