CENP-Fisacell-cycledependentkinetochoreprotein,whoseexpressionandlocalization patterns are regulated in a cell cycle-dependent manner.CENP-F plays an important role in the development and progress of malignant tumor.The expression of CENP-F is up-regulated in many tumors.It serves as an important marker in cell proliferation.Studies have demonstrated that CENP-F is involved in tumor genesis, progress,invasiveness,relapse and prognosis.CENP-F might be a valuable prognostic marker and potential therapy target in cancer treatment.

Objective: To provide reliable prediction models based on dentoskeletal and soft tissue variables for customizing maxillary incisor positions and to optimize digitalized orthodontic treatment planning. Methods: This study included 244 Chinese women (age, 18–40 years old) with esthetic profiles after orthodontic treatment with fixed appliances (133 in group I: 1° ≤ The angle between the nasion [N]-A point [A] plane and the N-B point [B] plane [ANB] ≤ 4°; 111 in group II: 4° < ANB ≤ 7°). Dental, skeletal, and soft tissue measurements were performed on lateral cephalograms of the participants. Correlation and multiple linear regression analyses were used to determine the influence of dentoskeletal and soft tissue variables on maxillary incisor position. Results: The ideal anteroposterior position of the maxillary incisor varied between sagittal skeletal patterns. The position of the maxillary incisor correlated with the sagittal discrepancy between the maxilla and the mandible (ANB), protrusion of the midface, nasal tip projection, development of the chin, and inclination of both the maxillary and mandibular incisors. Distance from the maxillary central incisor to nasion-pogonion plane predicted using multiple linear regression analysis was accurate and could be a practical measurement in orthodontic treatment planning. Conclusions Instead of using an average value or norm, orthodontists should customize a patient’s ideal maxillary incisor position using dentoskeletal and soft tissue evaluations.

Objective This study aims to provide craniofacial features and incisor position prediction models among esthetics population after orthodontic treatment.Methods A total of 338 patients with esthetic profiles were se-lected from 1 055 post-orthodontic adults based on inclusion and exclusion criteria and scored by five dental students.Mean values of cephalometric measurement were demonstrated with gender and sagittal skeletal pattern(ANB)differ-ences assessed by generalized estimating equation.Correlations among age,skeletal,and soft tissue variables in differ-ent genders were determined.Multivariate analysis was used to assess the influence of skeletal and soft tissue variables on orthodontic incisor position.Results Within the esthetic cohort after orthodontic treatment,gender differences ex-isted in cranial and mandibular length,mandibular rotation,protrusion of pogonion,inclination of maxillary incisors,upper lip thickness,lower 1/3 face height,and nose protrusion.However,in class Ⅰ malocclusion,the development of the chin showed no significance,whereas the protrusion of the lower lip significantly differed between genders,with less protrusion in males.In males,the protrusion of lip and chin varied among groups,with thinner basic upper lip thick-ness of class Ⅱ than class Ⅰ and greater lower lip height of class Ⅲ than class Ⅰ.In females,the protrusion and height of the upper lip and chin varied in groups,with thicker basic upper lip thickness of class Ⅲ than class Ⅰ.Upper lip thickness,female basic upper lip thickness,and female lower lip height were correlated with age.The protrusion of the upper lip was mainly correlated with posterior cranial base,mandibular body length,ANB in male and SNA,ANB,sag-ittal maxillary length,mandibular rotation,and protrusion of pogonion in female.The protrusion of the lower lip in males was mainly correlated with ramus height,mandibular rotation,protrusion of pogonion in male and ANB,mandib-ular rotation,and protrusion of pogonion in females.After employing skeletal variables to fit dental parameters,optimal results were achieved in male IMPA(adjusted R2=0.712)and female G Vert-U1(adjusted R2=0.795).After employing skeletal and soft tissue variables simultaneously,optimal results were achieved in male and female G Vert-U1,which was mainly influenced by the protrusion of the chin and nasal base in males(adjusted R2=0.836)and the protrusion of the nasal base as well as ANB in females(adjusted R2=0.842).Conclusion This study demonstrated the craniofacial features of esthetics population after orthodontic treatment and revealed the correlation of gender,age,skeleton,and soft tissues to provide reliable prediction models for aesthetic orthodontic incisor position.