Objective To explore the corelations between trace protein in urine and early kidney damage in gestational hypertension disease.Methods 126 patients with gestational hypertension disease were selected as the observation group,and 100 cases of healthy pregnant women over the same period were selected as the control group.The urinary albumin content of pregnant women in the two groups was detected and compared.Results In the observation group,the content of urinary albumin was (34.86 ± 18.41) mg/L,and positive patients in 56 cases,negative in 70 cases.In the control group,the content of urinary albumin was (18.64 ± 16.45)mg/L,and positive patients in 12cases,negative in 88 cases.The differences of the urinary albumin content and positive rates between the two groups were statistically significant(t =6.89,x2 =27.90,all P ＜ 0.05) ;The systolic blood pressure of urinary albumin-positive patients and negative patients in the observation groups were (155.6 ± 18.4) mm Hg,(146.3 ± 18.7)mm Hg,respectively,and the difference was statistically significant (t =2.79,P ＜ 0.05).Conclusion Urinary albumin testing during pregnancy can effectively determine the existence of early renal damage in patients with gestational hypertension disease,and it can help to judge the severity of gestational hypertension disease.

Graves′ orbitopathy is one of the complications related to Graves′ disease. Currently, there is still no available medical therapy provides reliable and safe benefit. Basic and clinical researches on insulin-like growth factor-Ⅰ(IGF-Ⅰ)receptor have found that IGF-Ⅰ receptor has implicated in the pathogenesis of Graves′ orbitopathy. As an IGF-Ⅰ receptor monoclonal antibody, teprotumumab was recently approved for this indication in the United States. It suggested that the therapy targeting on IGF-Ⅰ receptor pathway will soon take its place in the therapeutic armamentarium for active Graves′ orbitopathy.

In 2020, the French Endocrine Society released a consensus statement on the management of thyroid dysfunction in the elderly. This consensus introduced the physiological evolution of thyroid aging, determined specific reference range of thyroid stimulating hormone in the elderly and provided a standard guidance for diagnosis and treatment of thyroid dysfunction. However, some of these recommendations are still controversial, especially the reference range of thyroid stimulating hormone and interventions for subclinical hypothyroidism in the elderly. Thus, further studies for the elderly in China are reguired in order to promote the standardized management of thyroid dysfunction.