Objective To study the relationship between urinary ceruloplasmin(CP)and diabetic nephropathy. Methods Two hundred and thirty-six patients with type 2 diabetes mellitus were divided into normal albuminuria group(DMN group, 129 cases) and micro-albuminuria group ( DMMA group, 107 cases).Eighty-one healthy people were admitted into control group. The levels of urinary CP, serum CP, urinary albumin(Alb)and urinary creatinine(Cr)were measured. Results The median of urinary CP/Cr in DMMA group (2.55 ng/mmol) and DMN group (1.18 ng/mmol )was higher than that in control group(0.92 ng/mmol )(P<0.01 ). There was no significant difference in the levels of serum CP in each group (P>0.05 ).The urinary Alb/Cr was significantly positively correlated with urinary CP/Cr (r=0.188 ,P<0.01 )in patients with type 2 diabetes mellitus. The course of diabetes mellitus was a risk factor of urinary CP/Cr and Alb/Cr increase. Conclusions The urinary CP shows increasing tendency in accord with urinary Alb in type 2 diabetes mellitus patients. Urinary CP elevates obviously and correlates with diabetic nephropathy. Urinary CP may be used to monitor the onset, progress and therapeutic effect of diabetic nephropathy.

Objective To investigate the intelligence, individuality and behavior characteristics of epilepsy children with sub-clinical seizure. Methods The intelligence, individuality and behavior characteristics of the patients and normal age-matched children were evaluated by WISC, EPQ and CBCL. Results Compared with normal age-matched children, the code and number of WISC were obviously decreased in the children with epilepsy (P