1.Effect of scenario-exercises health guidance on postoperative functional exercise of patients with cervical can cer
Yingbi HUANG ; Jing WU ; Jie XU
Chinese Journal of Modern Nursing 2014;20(34):4306-4309
Objective To discuss the effect of scenario-exercises health guidance on postoperative functional exercise of patients with cervical cancer.Methods Select 100 cervical cancer patients who admitted to our department for radical resection during January 2012 to January 2014.In accordance with the principles of randomized control, we divided them into the experimental group and the control group, and each group got 50 patients.The control group received routine care and health guidance, while on the basis of routine care, the experimental group underwent scenario-exercises health guidance.The effect of postoperative functional exercise of the two groups was observed and compared.Results After removing the tube, the residual urine volume of the experimental group was (108.5 ±41.2)ml, which were significantly higher than (58.3 ±36.7)ml of the control group (t=6.433,P<0.01).Two patients in the experimental group had urinary retention, with the incidence of 4%, and ten patients in the control group had urinary retention, with the incidence of 20%.There was a significant difference between groups (χ2 =6.060 6,P<0.05).When the tube was just removed, the two groups had no significant difference in the quality of life (P>0.05), while six months after the exercise, there was a significant difference in the quality of life between two groups ( P <0.05 ) .Conclusions Scenario-exercises health guidance can significantly improve the effect of postoperative functional exercise in patients with cervical cancer, and it is worthy of promoting.
2.Exploring Quality Makers of Xiaoqinglong Granules in Treating Bronchial Asthma Based on Analytic Hierarchy Process-entropy Weight Method, Network Pharmacology and Molecular Docking
Huijuan XIE ; Zhuqian TANG ; Dan HU ; Yingbi XU ; Li HAN ; Bin YANG ; Hua LI
Chinese Journal of Experimental Traditional Medical Formulae 2025;31(22):192-200
ObjectiveTo investigate the quality markers of Xiaoqinglong granules(XQLG) for treating bronchial asthma using the analytic hierarchy process(AHP)-entropy weight method(EWM), network pharmacology and high performance liquid chromatography(HPLC) content determination. MethodsEffectiveness, testability and peculiarity component data of XQLG in treating bronchial asthma were constructed through database retrieval, literature review, and network pharmacology. Subsequently, AHP-EWM was used to quantitatively identify and weight the control layer and element layer, the relevant compounds were selected as candidate quality markers based on comprehensive scores. Further comparison of reference substances and establishment of HPLC content determination method were used to determine the potential quality markers of XQLG, which were verified by molecular docking with disease targets. ResultsA total of 13 components, including glycyrrhizic acid, paeoniflorin, schisandrol A, isoliquiritigenin, 6-gingerol, ephedrine, liquiritin, albiflorin, liquiritigenin, 6-shogaol, pseudoephedrine, cinnamic acid and cinnamaldehyde, were identified as potential quality markers of XQLG by AHP-EWM. Quantitative analysis indicated that all aforementioned quality markers could be detected in 13 batches of XQLG, indicating that it had stable testability as a quality marker. Among these 13 batches of samples, ephedrine and paeoniflorin exhibited good consistency in content, while pseudoephedrine and cinnamaldehyde showed poor consistency. Molecular docking analysis revealed that the 13 compounds exhibited binding energies with the core targets -2.11 kcal·mol-1, indicating that the 13 compounds could spontaneously bind to the disease targets, which may be the material basis for the treatment of bronchial asthma with XQLG. ConclusionIn this study, 13 compounds were screened by AHP-EWM combined with network pharmacology and HPLC as quality markers for the treatment of bronchial asthma by XQLG, laying the foundation for enhancing the quality standards of this preparation.

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