Objective To compare the clinical results of endodontic mandibular first molar by different restoration methods.Methods From January 2011 to February 2013,96 patients in our hospital dental visits with 110 defective teeth who accepted the dental restoration were randomly selected in this clinical research.The repairing of defective teeth were divided into 3 groups randomly:36 were fabricated with CAD/CAM zirconia all -ceramic crowns,35 were CAD/CAMzirconia all -ceramic onlays,39 were direct filling and repairing with composite resins. The clinical effects of 3 groups were evaluated and compared at baseline,and 1,6,12 months after restoration using modified USPHS criteria.The results were analyzed statistically by SPSS 13.0.Results It was not found that 110 defective teeth were debonded at 12 months after restoration.There were significant differences in assessment results of secondary caries,marginal fitness,appearance and color matching at 12 months after restoration by different restoration methods (χ2 =6.705,7.768,6.910,11.624,all P <0.05).Conclusion The dental restorations with CAD/CAMzirconia all -ceramic crowns and CAD/CAM zirconia all -ceramic onlays show satisfactory clinical performance in short time.

Blood Volume ; Child ; Edema ; etiology ; therapy ; Evidence-Based Medicine ; Hemofiltration ; methods ; Humans ; Nephrotic Syndrome ; complications ; therapy ; Renal Dialysis ; methods ; Severity of Illness Index

Child ; Chronic Disease ; Humans ; Kidney Diseases ; therapy ; Kidney Failure, Chronic ; therapy ; Nutritional Support ; Renal Insufficiency, Chronic ; therapy

Objective To analyze the diagnostic methods and etiological factors in patients with fever of unknown origin (FUO).Methods The clinical data of 358 patients with FUO,Who were treated in hospital since February 2001 to April 2005,were retrospectively analyzed.Results Among the 358 patients,312 patients were definitely agnosed(87.2%),A- mong the 312 definitely diagnosis patients,172 cases were infectious disease(132 cases were bacterial infection,31 cases were virus infection,6 eases were fungus infection and 3 cases belonged to other disese),143 cases were bacterial were non-infections disease(66 cases were collagen vascular diseases,63 cases were malignant tumor and 14 cases belonged to other disese).46 cases remained origin-unknown until they were discharged from hospital.Conclusion In the diag- nosis of FUO,We should manage to collect oathogenic,immunologic and pathologic evidences.Infectious diseases,collagen vascular diseases and malignant tumors are the main causes of FUO.

Coronary Stenosis ; diagnostic imaging ; Humans ; Ultrasonography, Interventional ; methods

Objective To study the distribution of drug resistance mutations and genotypes in the patients with chronic hepatitis B(CHB)in Taicang area.Methods 350 cases of CHB were selected and detect the drug resistance mutations and genotypes before using nucleoside(acid)anti-viral drugs.The correlation between the drug resistance mutations with genotypes in CHB patients was analyzed.Results Among 350 cases of CHB,the distribution of genotypes was genotype B in 172 cases,accounting for 49.14%, genotype C in 164 cases,accounting for 46.85%,genotype D in 9 cases,accounting for 2.57%,mixed genotype of B and C in 5 ca-ses,accounting for 1.42%,no other genotypes were found.In this study,the drug resistance mutations were detected in 58 cases,in-cluding 22 cases of genotype B,35 cases of genotype C and 1 case of genotype D,no drug resistance mutations were found in mixed genotype B and C.The drug resistance mutations sites:lamivudine resistance-associated mutations in 36 cases(10.28%),and adefo-vir resistance-associated mutations in 16 cases(4.57%)and entecavir associated resistance mutations in 6 cases(1.71%).Conclusion The genotype of CHB patients in Taicang area was dominated by genotype B and C,which accounting for more than 90% and the proportion of these two kinds of genotype is similar.The proportion of drug resistance mutation occurrence in the patients with gen-otype C is higher than that with genotype B.The lamivudine resistance-associated mutation has the highest proportion of drug re-sistance occurrence.It is suggested that the CHB patients with undefined medication history and recurrence treatment should be per-formed the drug resistance detection for selecting the targeted therapeutic schemes before accepting nucleoside(acid)drug therapy.

Proximal transparent cap of endoscope has an important effect in endoscopic diagnosis and treatment, including endoscopic submucosal tumor ligation, endoscopic mucosal resection, endoscopic removal of foreign body, endoscopic variceal ligation and sclerotherapy, endoscopic submucosal dissection, peroral endoscopic myotomy, endoscopic submucosal dissection through tunnel.This article reviewed the effect of different transparent caps in endoscopic diagnosis and treatment.

Child ; Cyclophosphamide ; therapeutic use ; Humans ; Immunosuppressive Agents ; therapeutic use ; Nephrotic Syndrome ; drug therapy ; Treatment Outcome

Objective The aim of this study was to understand the role of specific markers of stem cells Oct-4 expression in the development of human epidermal non-melanoma cutaneous tumors.Methods The paraffin-embedded samples were retrieved from files of pathology department at our hospital,including 20 cases of skin squamous cell carcinomas (SCC),20 cases of basal cell carcinomas (BCC),20 cases of seborrhoeic keratosis (SK) and 20 cases of normal skin (from head,face,trunk,extremities).The expression of Oct-4 and PCNA were observed by immunohistochemical staining technique.Results Oct-4 protein was abnormally increased in SCC and BCC comparel to normal skin and SK ( P ＜0.05 ).However there were no significant difference of Oct-4 protein expression between SCC and BCC ( P ＞0.05).There were also no significantly different Oct-4 protein expression between Sk and the normal skin ( P ＞ 0.05 ),and no significantly different Oct-4 protein expression between SK and BCC( P ＞0.05 ).PCNA protein was abnormally increased in SCC and BCC compared to normal skin and SK ( P ＜0.01 ).There were significantly different PCNA protein expression between SCC and BCC( P ＜0.05).There were also significantly different PCNA protein expression between SK and the normal skin ( P ＜ 0.05 ).However there were no significant difference of PCNA protein expression between SK and BCC ( P ＞ 0.05 ).There were positive correlation between the expression intensity of Oct-4 and PCNA in SCC and BCC.Conclusions The abnormal expression of Oct-4 may have an important role in the development of BCC and SCC.Positive Oct-4 expression cells may be the tumor stem cell in SCC and BCC.There were positive correlation between the expression intensity of Oct-4 and PCNA in SCC and BCC.The over expression Oct-4 in BCC and SCC may play an important role in proliferation of tumor.

Despite a combination of all available treatment, the mortality of liver failure is very high,especially in children patients. Artificial liver support methods have been tested for over 50 years. Standard techniques of blood purification like hemodialysis, adsorption, hemo or plasma filtration as well as bioreactorbased approaches using liver cells or tissues have been used. It' s believed that the damaged liver has the ability to return to normal. Artificial liver support systems are expected to be useful for temporary support of liver function. If the liver does not regenerate to normal functions, an artificial liver support system may be useful as a bridge to liver transplantation. In conclusion, artificial liver support method appears to be a reliable therapy for advanced liver diseases and has significantly decreased the mortality of liver failure. Artificial liver support system has been used in children patients as well, but it still needs more researches.