1.Inversion of unerupted second deciduous molar and second premolar: a case report.
Weiguo QU ; Ying WANG ; Xin FENG
West China Journal of Stomatology 2014;32(1):99-100
Impacted teeth are usually involved in permanent dentition but not in primary dentition. This paper reports a clinical case of unerupted mandibular second deciduous molar inferior to the second premolar.
Bicuspid
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Dentition, Permanent
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Humans
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Mandible
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Molar
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Tooth, Deciduous
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Tooth, Impacted
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Tooth, Unerupted
2.Vasodilator effect of oroxylin A on thoracic aorta isolated from rats.
Hong WANG ; Jingtian QU ; Xin ZHAO ; Ying GUO ; Haoping MAO
Journal of Integrative Medicine 2012;10(8):880-5
To investigate the vasodilator effect and the endothelium-dependent mechanism of oroxylin A in thoracic aorta isolated from rats.
3.Therapeutic effects of prostaglandin E1 on diabetic nephropathy in different periods in the elderly people
Ying XIN ; Jianjun DONG ; Yong QU ; Lin LIAO
Chinese Journal of Geriatrics 2008;27(7):498-501
Objective To investigate the effects of prostaglandin E1(PGEl)in improving proteinuria and albuminuria in the elderly people with diabetic nephropathy(DN). Methods Patients including stage Ⅲ,stage Ⅳ and stage Ⅴ were divided into four groups:conventional therapy group,PGE1 group,PGE1+ACEI group and ACEI group.Proteinuria and albuminuria were measured before and after treatment for 15 days,3 months,6 months. Results (1)In the DN patients in stage Ⅲ and stage Ⅳ (proteinuria<2.5 g/d),the proteinuria and albuminuria descended markedly in PGE1+ACEI and PGEl group(P<0.01).It was better than that in eonventionaI therapy and ACEI group.(2)In the DN patients in stage Ⅳ(proteinuria>2.5 g/d),proteinuria and albuminuria were not changed significantly after 3 months and 6 months in PGE1+ACEI and PGE1 group,but they were increased in conventional group(P<0.05).(3)In the DN patients in stage Ⅴ,the proteinuria and albuminuria were not changed much after 1 5 days,3 months and 6 months(P<0.05).The proteinuria and albuminuria were increased by more than 10 percent(P<0.01)in the conventional group after 3 and 6 months. Conclusions The therapeutic effects of PGE1 are obvious.Early treatment of nephropathy will get a better improvement in patients with diabetic nephropathy.
4.Short and long term therapeutic effects of prostaglandin El treatment on diabetic nephropathy
Yaru MU ; Jianjun DONG ; Ying XIN ; Yong QU ; Lin LIAO
Chinese Journal of Geriatrics 2010;29(1):20-23
Objective To investigate the short and long term therapeutic effects of prostaglandin E1 (PGEl) on diabetic nephropathy (DN). Methods Patients with DN in stage Ⅲ to Ⅴ according to Mogensen criteria were randomly assigned to four groups of PGE1, angiotensin-converting enzyme inhibitor (ACEI), PGE1 + ACEI and control drug. The levels of proteinuria and albuminuria were measured before and 15 days, 6 months and 18 months after treatment. Patients with DN in stage Ⅳ were subdivided into three groups according to proteinuria: early stage IV (protienuria was less than 1.5 g/d), middle stage Ⅳ (protienuria was between 1.5 g/d and 2.5 g/d) and late stage Ⅳ (protienuria was larger than 2.5 g/d). Results Fifteen days after treatment, the levels of proteinuria and albuminuria were significantly decreased compared with pre-treatment in PGE1 and PGE1 + ACEI groups (P<0. 01), and the therapeutic effect was better in PGE1 + ACE1 group than in ACEI group (P<0. 01). Six months after treatment, there were still significant differences in above parameters in patients with DN in stage Ⅲ and Ⅳ between PGE1 + ACEI and PGE1 groups. And for the patients in stage Ⅴ, statistic significance between pre-and post-treatment existed only in PGE1 + ACEI group (P<0. 05). but not in PGE1 and ACEI groups (both P>0. 05). Eighteen months atter treatment, the levels of proteinuria and albuminuria were significantly decreased in patients in stage HI and early stage IV in all treatment groups (P<0. 01). For patients in middle stage IV and late stage Ⅳ , the significant differences still occurred between pre-and post-treatment in PGE1 + ACEI group (P<0. 01 or P<0. 05), and were significantly better than in ACEI group (P<0. 01 or P<0. 05). However, the proteinuria of patients in late stage IV elevated in PGE1 group in post-treatment versus pre-treatment (P<0. 05). Conclusions The short term therapeutic effect of PGE1 is quick and good in patients with DN. The therapeutic effect is much better in patients in stage Ⅲ compared with stage Ⅴ. The combination of PGE1 and ACEI will get better best therapeutic effect than PGE1 or ACEI alone in long term.
5.Therapeutic effects of gensenoside-Rg3 combined with radiotherapy on advanced non-small cell lung cancer
Xin JIANG ; Ying XIN ; Jinghua LUO ; Pengyu CHANG ; Qi FENG ; Yaqin QU
Chinese Journal of Radiological Medicine and Protection 2012;32(2):196-198
Objective To study the efficacy and toxicity of gensenoside-Rg3 (Rg3) combined with radiotherapy on non-small cell lung cancer ( NSCLC ) at advanced stages (Ⅲ and Ⅴ ).Methods Sixty-three patients with stage Ⅲ or Ⅳ NSCLC were divided randomly into two groups:treatment group ( n =35 ) treated with Rg3 combined with radiotherapy and control group ( n =28 ) treated with radiotherapy alone.The efficacy and side effects were compared after the treatment.Results The response rate ( CR + PR) of the treatment group was 57.14%,significantly higher than that of the control group (32.14%,x2 =3.91,P < 0.05).The median survival time of the treatment group was 14.2 months,significantly longer than that of the control group ( 11.2 months,x2 =2.07,P < 0.05 ).The one-year survival rate of the treatment group was 62.86%,significantly higher than that of the control group (39.29%,x2 =4.40,P <0.05).The incidence rates of side effects of the treatment group were all lower than those of the control group,but there were not significant difference. Conclusions Gensenoside-Rg3 combined with radiotherapy is effective for advanced stage NSCLC,with attenuation and synergistic effects.
6.Measurement of Serum Interleukin-16,-10 and Immunoglobulin E in Asthmatic Children and Its Significance
xiu-juan, WANG ; shu-qiang, QU ; ying-xin, FU ; shu-sheng, LIU
Journal of Applied Clinical Pediatrics 2004;0(07):-
Objective To discuss the level and its relativity analysis of IL-16 and IgE in asthmatic children .Methods Compare and analyze the level of IL-16,IL-10 and IgE between 18 asthmatic children and 14 healthy children.Results The serum level of IL-16 and IgE in asthmatic children was much higher than the contrast, P
7.Study on pathomorphological changes of the Iiver in Beagle Dog with spontaneous hepatocirrhosis
Jianting HU ; Bo QIU ; Yong YING ; Huijin QU ; Fengqian WANG ; Xin ZHANG
Chinese Journal of Comparative Medicine 2016;26(12):55-58
Objective To study the liver pathomorphological and serum biochemical changes in Beagle dog with spontaneous hepatocirrhosis and establish the backgroud information of experimental animals for GLP .Methods The ALT, AST,TP,ALB, ALP, TBIL, TC, TG and GGT were detected using an automatic biochemical analyzer , and compared the differences of above index between blank control and diseased animal .The histological changes of the liver were observed by optical microscopy.Results Compared with the blank control ,the ALT,AST,ALP,TBIL and GGT of diseased dogs were increased significantly , and the ALB decreased significantly .Compared with normal dogs , the liver cells had nodular regeneration , arranged irregularly and pseudolobule formation .The pseudolobules were packaged with collagen fibers . Conclusion It is suggested that spontaneous lesions in Beagle dogs should be monitored so as to provide appropriate experimental animal histopathologicalbackgroud information for drug safety evaluation .
9.Expression and significance of Notch1, Jagged1 and VEGF in human non-small cell lung cancer.
Xin JIANG ; Jian-hua ZHOU ; Zheng-hao DENG ; Xiao-hui QU ; Hai-ying JIANG ; Ying LIU
Journal of Central South University(Medical Sciences) 2007;32(6):1031-1036
OBJECTIVE:
To determine the expressions of Notch1, Jagged1 and vascular endothelial growth factor (VEGF) in human non-small cell lung cancer (NSCLC) and to explore its clinical pathological significance.
METHODS:
Immunohistochemical SP method was used to detect the expressions of Notch1, Jagged1 and VEGF in 65 patients with NSCLC and 15 normal epithelial tissues of the lung, and the relationship between them and clinic-pathological parameters were analyzed.
RESULTS:
The positive rates of Notch1, Jagged1 and VEGF in NSCLC were 81.5%, 83.1% and 93.8%, respectively, higher than those in normal epithelial tissues of the lung (P<0.05). The positive expression levels of Notch1 and VEGF were closely associated with the tumor stage and the lymph node metastasis (P<0.05). The positive expression levels of Jagged1 was positively correlated with the pathological type and lymph node metastasis. There was a positive correlation between Notch1, Jagged1 and VEGF.
CONCLUSION
Notch1, Jagged1 and VEGF protein may play an important role in the pathway of carcinogenesis and progression of NSCLC. The up-regulation of Notch1, Jagged1 and VEGF protein expression probably predict NSCLC carrying relatively strong permeation and metastasis.
Adult
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Aged
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Calcium-Binding Proteins
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metabolism
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Carcinoma, Non-Small-Cell Lung
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metabolism
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pathology
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Female
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Gene Expression Regulation, Neoplastic
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Humans
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Intercellular Signaling Peptides and Proteins
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metabolism
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Jagged-1 Protein
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Lung Neoplasms
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metabolism
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pathology
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Lymphatic Metastasis
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Male
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Membrane Proteins
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metabolism
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Middle Aged
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Neoplasm Staging
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Receptor, Notch1
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metabolism
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Serrate-Jagged Proteins
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Vascular Endothelial Growth Factor A
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metabolism
10.WT1 downregulation during K562 cell differentiation and apoptosis induced by bufalin.
Yunpeng LIU ; Xiujuan QU ; Pingping WANG ; Xin TIAN ; Ying LUO ; Shizhou LIU ; Xianglan LU
Chinese Journal of Hematology 2002;23(7):356-359
OBJECTIVETo study the change of WT1 gene expression during human leukemic K562 cell differentiation and apoptosis induced by bufalin.
METHODSCell viability was determined by trypan blue exclusion, cell differentiation and apoptosis by nitro blue tetrazolium (NBT) reduction test, morphology and flow cytometry, expression of WT1 protein by Western blot analysis, and expression of WT1 mRNA by reverse transcriptase-polymerase chain reaction (RT-PCR).
RESULTS(1) The cell proliferation was inhibited by bufalin and the IC(50) at 24, 48, 72 h were 0.026, 0.032 and 0.006 micro mol/L, respectively. (2) Bufalin induced K562 cell differentiation towards macrophage/monocyte within concentration from 0.01 to 0.05 micro mol/L and apoptosis at higher than 0.026 micro mol/L. (3) The expression of WT1 protein and mRNA were downregulated by bufalin in the initial stage of differentiation and apoptosis induced by bufalin.
CONCLUSIONK562 cell differentiation and apoptosis induced by bufalin might relate to the downregulation of WT1 expression.
Apoptosis ; Cell Differentiation ; Cell Proliferation ; Down-Regulation ; Humans ; WT1 Proteins ; genetics