Research on the application of ocular response analyzer has become one of the main issues in ophthalmology.The ocular response analyzer has been used in the measurement of ocular bioparameters of glaucoma,cataract,heretability and refractive surgery.As a newly invented non-contact tonometric device,the ocular response analyzer is helpful not only in the measurement of intraocular pressure (IOP),but also in the determination and calculation of two corneal biomechanical properties:corneal hysteresis (CH) and corneal resistance factor (CRF).It offers the possibility of measuring corneal biomechanical properties in vivo.This article primarily reviewed the application of the ocular response analyzer in terms of pre-operative examination and post-operative follow-up in excimer laser surgery.

OBJECTIVE:To discuss the manifestation characteristics of mezlocillin injection-induced ADR.METHODS:Mezlocillin injection-induced ADR cases reported in domestic pharmaceutical journals between 1999 and July.2006 were retrieved from China Hospital Digital Library(CHDL) and analyzed statistically.RESULTS:The clinical manifestation of ADR induced by mezlocillin was characterized by allergic reactions or even anaphylactic shock.The major ADR types were first-using immediate type and the speedy outbreak type.CONCLUSION:Great importance should be attached to allergic reactions induced by mezlocillin injection.

OBJECTIVE:To discuss the general rules and characteristics of adverse drug reactions(ADRs)of lamivudine.METHODS:43national case reports of ADRs of lamivudine between1999and2005were classified and analyzed statistically.RESULTS:The affected patients ranged in age from8years to45years,with more males than females.There were no rules in the onset time of ADRs.The ADRS were mainly characterized by nervous system responses and aggravation of hepatitis in clinic.CONCLUSION:Great importance should be attached to ADRs of lamivudine to ensure the safety of drug use in clinic.

Herbicides ; poisoning ; Humans ; Paraquat ; poisoning ; Poisoning ; complications ; therapy

Objective: To develop Chinese Marital Motivation and Reason Inventory (CMMRI) and examine it's reliability and validity. Methods: A 40-items, self-report measure of marital motivation and reason was developed based definition of marital motivation and reason and clinical experiences. The test-retest reliability, split-half reliability, internal consistency reliability, construct validity, and empirical validity were examined in the general sample of 1303 subjects, retest sample of 52 subjects, and validity sample of 95 subjects, aged from 6 to 91 years. Results: The stability coefficients, split-half reliability, Cronbach's ?coefficients were 0.62~0.80, 0.61~0.79 and 0.62~0.80 for 4 dimensions. There were significant differences between subjects in separation and divorcee and subjects in marriage on the CMMRI. In the confirmatory analysis of four factors model, fit statistics for the model best explained the observed relationships between the item scores and they attained the lower x2/df ratios and RMSEA, and higher IFI, TLI, CFI, PNFI and PCFI. Conclusion: The stability, internal consistency, and validity of the CMMRI are good and meet with psychometric standard.

0.05).Conclusion The curative effect of moxibustion and Shenlingbaizhu pills are definite to AIDS associated diarrhea.The treatment can improve the quality of life of AIDS patients with good safety.

OBJECTIVE:To observe clinical efficacy of Felodipine sustained-release tablets(Ⅱ)in the treatment of elderly es-sential hypertension and its improvement effect on arterial elasticity,left ventricular remodeling and the quality of life. METHODS:A total of 96 elderly patients with essential hypertension in our hospital during Aug. 2014-Dec. 2015 were divided into observation group (50 cases) and control group (46 cases) according to random number table. Observation group was given Felodipine sus-tained-release tablets(Ⅱ)5 mg orally,qd,with empty stomach in the morning;control group was given Irbesartan tablets 150 mg, qd,with empty stomach in the morning. Both groups received treatment for 12 weeks. Clinical efficacies of 2 groups were observed as well as 24 h ambulatory blood pressure (ABP),indexes of arlerial elasticity [carotid-radial pulse wave velocity (CR-PWV),carot-id-femoral pulse wave velocity (CF-PWV)], indexes of left ventricular remodeling [diastolic interventricular septum thickness (IVST),diastolic left ventricular posterior wall thickness(LPWT),left ventricular end diastolic diameter(LVIDd)] before and after treatment. The physiological function (PF),social function (SF),role-physical (RP),body pain (BP),mental health (MH),role-emotional(RE),vitality(VT)and general health(GH)score of SF-36 were observed in 2 groups before and after treatment. The occurrence of ADR was compared between 2 groups. RESULTS:There was no statistical significance in total response rate be-tween 2 groups (P>0.05). There was no statistical significance in 24 hABP,CR-PWV,CF-PWV,IVST,LPWT,LVIDd,SF-36 score between 2 groups before treatment(P>0.05). After treatment,the levels of 24 hSBP,24 hDBP and 24 hMAP in 2 groups were decreased significantly,and 24 hSBP and 24 hMAP of observation groups were significantly lower than those of control group,with statistical significance (P<0.05). There was no statistical significance in 24 hDBP (P>0.05). The levels of CR-PWV,CF-PWV, IVST and LPWT in observation group were decreased significantly,and the levels of CR-PWV and LPWT in control group were also decreased significantly. The levels of CR-PWV,CF-PWV,IVST,LPWT and LVIDd in observation group were significantly lower than control group,with statistical significance (P<0.05). SF-36 scores of 2 groups were increased significantly,and the scores of BP,VT,MH and GH in observation group were significantly higher than control group,with statistical significance (P<0.05). There was no statistical significance in scores of PF,SF,RP and RE. There was no statistical significance in the incidence of ADR be-tween 2 groups(P>0.05). CONCLUSIONS:Felodipine sustained-release tablets(Ⅱ)exhibit significant effect and small blood pres-sure fluctuation in the treatment of elderly essential hypertension,and can improve the quality of life with good safety.

Objective To study the relationship of peripheral vascular disease(PVD) with gender and serum uric acid in patients with type 2 diabetes.Methods Lower extremities of 82 male and 70 female patients with type 2 diabetes were screened for PVD by color Doppler uhrasonography,and the levels of serum uric acid,fasting blood glucose,glycosylated hemoglobin and serum lipid were examined.Results In male,serum uric acid(328.12?107.30) ?mol/L,age(65.00?9.66) yrs,durations of diabetes(7.38?6.17) yrs, HBA_1Cc(7.74?1.83)% were significantly higher in the diabetic patients with PVD than those in patients without PVD.And these changes were not shown in female patients.In male,the detectable rate of PVD(82.14%)in diabetics with high level uric acid was also increased than that in normal uric acid group(53.70%).Conclusion The higher level of serum uric acid in type 2 diabetics was closely related with the occurrence of peripheral vascular disease in male.So we should actively control the level of serum uric acid in male.

[Summary] With populational proportional sampling (PPS) method in Baiguo village,one central primary sehool was selected,and villagers aged 20-80 in nearly village were chosen as control.Cross-seetional survey methodology was employed,B-type ultrasonography was used to determine thyroid volume and nodule of ebildren.Arsenic cerium catalytic spectrophotonetric assay was employed to detect urinary iodine.A direct titration measurement was used to determinate iodine content in salt.180 children aged 6-12 were surveyed,2 cases of goiter were found (1.11％).16 cases of thyroid nodules were discovered(8.89％),including 3 boys(3.45％,n =87) and 13 girls(13.98％,n =93).Girls had a higher prevalence than boys (x2 =6.154,P =0.015).The prevalence of thyroid nodules in that village was 24.51％,being statistically significant between 2 groups (x2 =17.368,P =0.001),and increasing with the age.

Objective To analyze the related literature of natural orifice translumenal endoscopic surgery(NOTES),discuss the development status and direction of the NOTES.Methods NOTES related documents were retrieved from the China National Knowledge Internet(CNKI),Wanfang Data,China Biomedical Literature Database(CBM) and Superstar Medalink.The related project were statistically analyzed.Status quo and development direction were analyzed.Results The journal of NOTES literature was scattered,involving numerous departments,especially the gastroenterology,urology,oncology,obstetrics and gynecology.The largest number of NOTES were reported in the vagina,followed by the stomach and the rectum.The post agencies and the area were mainly in the developed areas of strong scientific research colleges and universities and clinical teaching hospitals.The most published types of literature at present were the research and review of NOTES combined laparoscopy,and more basic research literature.The directions of collecting the reseach of NOTES by keywords were main from several aspects:NOTES combined with laparoscopy for colorectal cancer,urology,hepatobiliary surgery,cardiothoracic surgery,and so on;NOTES in animal experimental study;the application range included NOTES devices,work space, artificial interface for disease,and development of NOTES.Conclusion NOTES is the current research hotspot.Currently the domestic development is relative lag,which is in the primary stage of development.The basic research of NOTES need further study and clinical application need to strengthen,otherwise,application of NOTES instrument need to speed.