Moxibustion therapy is a commonly used external treatment method for numerous conditions and general health care. Besides the effects of the drugs, infrared-heat and radiation spectrum are also the manner of action. By collecting the literature about thermal radiation and infrared spectrum features of moxibustion, the author reported the novel studies on the thermal effect of moxibustion including factors that impacted the temperature, infrared spectrum features, apparatus based on infrared technology employed in clinic for moxibusiton and characteristics of temperature sensitivity. The author also identified some existing problems and provided advice for future application and research.

China ; Female ; Humans ; Neoplasms ; prevention & control ; therapy

Objective To observe MRI features of the localized intra-articular form of pigmented villonodular synovitis (PVNS) within the knee joint. Methods Fifteen patients with pathologically proved localized intra-articular form of PVNS were retrospectively reviewed, and the MRI appearances were observed. Results Solitary nodule or mass within the knee joint was detected in all 15 patients. The lesion located in the infra-patellar fat pads in 11 patients. Most lesions were round or oval, with a well-defined margin. The maximum diameters ranged from 2.0 cm to 6.0 cm, with a mean value of 3.1 cm. The signal intensity of these lesions was characteristically heterogeneous on SE T1WI, TSE PDWI, and TSE T2WI, and the whole signal was similar to that of muscles on SE T1WI and TSE PDWI, but a little higher on TSE T2WI. Prominent low signal intensity on T2WI because of deposition of hemosiderin was found within 14 lesions, and 9 of 15 lesions showed characteristically low signal marginal rim. Conclusion MRI features of the localized intra-articular form of PVNS include a well-defined solitary nodule or mass locating in the infra-patellar fat pad, heterogeneous signal intensity, and prominent interior focal low signal or peripheral low signal rim on T2WI.

The incidence of open-angle glaucoma has been rising year after year in China, which has caught much at-tention from ophthalmologists.There are various methods to evaluate the disease progression of an open-angle glaucoma pa-tient.These methods can be divided into two classes:functional assessment and structural assessment.We survey these two classes of methods in this paper.

Objective To explore the effects of mindful- based stress reduction exercise on the sleep and negative emotion in Primary glaucoma patients. Methods By using random sampling,primary glaucoma patients at the hospital of between September in 2015 and September in 2016. A total of 93 patients were divided into intervention group and control group according to random number table.The control group was given conventional nursing, intervention group joined in mindful-based stress reduction exercise on the basis of routine nursing. Baseline levels of anxiety, depression and status of sleep were measured in the two groups after admission, evaluated and comparison at the end of formal intervention. Results At the end of intervention, the score of Hamilton Anxiety Scale (HAMA) in intervention group was decreased from (13.42 ± 3.56) points to (8.23 ± 2.11) points (t=7.832, P=0.000), the score of Hamilton Depression Scale (HAMD) was decreased from (18.42 ± 4.55) points to (10.31 ± 2.76) points (t=9.517, P=0.000), the effect was better than the control group (t=8.117, 7.671, all P=0.000). And the score of Self-Rating Scale of Sleep (SRSS) was decreased from (30.81±8.35) points to(25.52±6.13) points (t=3.189, P=0.002), the effect was better than the control group (t=2.253, P=0.027). Conclusions Mindful-based stress reduction exercise can reduce negative emotions such as anxiety and depression and promote the status of sleep effectively.

Objective To discuss incidence and related risk factors of vascular cognitive impairment (VCI) after acute subcortical infarction (SI).Methods One hundred and eighty-two patients with acute SI were divided into two groups:VCI group (81 cases) and no-VCI group ( 101 cases) according to VCI diagnostic standard.Sex proportion,age,culture degree between two groups were compared,and correlation was analyzed between the quantity of risk factors and the incidence of VCI.Results The incidence of VCI after acute SI was 44.5％(81/182).According to age stratification,the incidence of VCI in the patients of 56-65 years was 35.4％ (23/65),in the patients of 66-75 years was 45.3％ (48/106),and in the patients of 76-85 years was 90.9％ (10/11 ).The age in VCI group was significantly higher than that in no-VCI group [(69.93 ±6.91) years vs. (67.62 ±5.56) years,P =0.014],and culture degree was significantly lower than that in no-VCI group (P =0.028).The sex proportion between two groups had no significant difference (P =0.876).The more accompanying risk factors,the higher incidence of VCI.Conclusions Along with the increase of age,the incidence of VCI after acute SI is higher.The more accompanying risk factors,the higher incidence of VCI.

AIM:To determine whether imperatorin would enhance the effect of doxorubicin therapy on cervi -cal cancer in vitro.METHODS:The viability of HeLa cells treated with imperatorin and doxorubicin was determined by MTT assay in vitro.The expression of Bcl-2 protein family ( Mcl-1, Bcl-2, Bcl-xL, Bad and Bax ) in HeLa cells treated with imperatorin and doxorubicin was evaluated by Western blot analysis .The apoptosis and mitochondrial membrane poten-tial (ΔΨm ) in the HeLa cells treated with imperatorin and doxorubicin were analyzed by flow cytometry .A Mcl-1 expres-sion vector was constructed , and its role in the cytotoxicity of imperatorin plus doxorubicin to HeLa cells was detected by MTT assay.RESULTS: Addition of imperatorin significantly enhanced the cytotoxicity of doxorubicin to HeLa cells in vitro.Mcl-1 expression was down-regulated by imperatorin but was not influenced by doxorubicin in the HeLa cells .A com-bination of imperatorin and doxorubicin induced apoptosis and ΔΨm collapse more significantly compared with the treatment with imperatorin or doxorubicin alone .Furthermore, the imperatorin-induced sensitization for doxorubicin cytotoxicity to HeLa cells was abolished by the transfection with Mcl-1 expression plasmid .CONCLUSION:The combination of doxoru-bicin with imperatorin enhances the antitumor effect of doxorubicin on cervical cancer cells via targeting Mcl -1.

Diabetic macular edema (DME) is thickening retina with two disc diameter,which is the leading cause of blindness in diabetic retinopathy patients.The initial studies demonstrated that laser treatment of DME prevented further visual deterioration but did not improve visual acuity.Although glucocorticoid slow-release system can extend the time of effective drug concentration,to help glucocorticoid better carry out its biological effect,further studies are needed to warrant their safety due to increasing intraocular pressure and cataract progression.Novel studies identifying the presence of vascular endothelial growth factor (VEGF) in the eye with DME allowed for the development of an alternative anti-VEGF therapy,which revolutionized the management of DME by not only preventing vision loss,but also improving overall vision.Anti-VEGF therapy is becoming the first-line treatment of DME.However,present treatment modalities including anti-VEGF for DME had limitations,which build on the current understanding of DME pathogenesis.Further in-depth study of the development and outcome of DME is needed to optimize the therapeutic schemes,based on objective and scientific observation of treatment response.Finally we need to fully utilize the public health services and clinical management resources for diabetic patients,to prevent the visual impairment of DME before its occurrence.

Objective To observe the effects of VEGF antisense oligonucleotide on growth of micrangium of xenograft in nude mice.Methods VEGF-ASODN was synthesised.After transfection with VEGF-ASODN,RNA copy was detected by real-time PT-PCR,VEGF protein was examined by ELESA,Survival of cells was tested by MTT.Growth of cells was shown by growth curve.After the model of human gastic cancer xenografts in nude mice was developed,model animals were divided randomly into three groups:antisense group、scrambled group and saline group.ResultsVEGF-ASODN can reduce the VEGF mRNA and VEGF protein in cells and supernate remarkably.Survival and growth of cells were suppressed.It can significantly reduce VEGF protein in serum of nude mice.It also reduced the volum and weight of xenografts.Density of micrangium decreased in xenografts.Conclusion VEGF-ASODN can suppress the growth of micrangium in xenografts.

Background and purpose:To study the expression of PTEN and P53 and analyse their roles in HGC oncogenesis,and to discover a good marker for diagnosis and prognosis of HGC.Methods:The expression of PTEN mRNA,PTEN protein and P53 protein were detected by in situ hybridization(DNA-RNA) and immunohistochemistry(SP method) in 64 cases of HGC.We took 22 cases of gallbladder adenoma and 10 cases of chronic cholecystitis as controls.Results:① The positive expression rates of PTEN mRNA and protein in HGC(56.3%,59.4%) were significantly lower than that in gallbladder adenoma(81.8%,90.8%) and chronic cholecystitis(100%,100%)(P