Gastrointestinal Stromal Tumors ; diagnosis ; epidemiology ; surgery ; Humans ; Stomach ; pathology

Colorectal Neoplasms ; pathology ; surgery ; Humans ; Liver Neoplasms ; secondary ; surgery ; Neck Dissection

Accurate preoperative staging is imperative in the treatment of gastric cancer since diseases in different stages mandate different management strategies. Multi-disciplinary therapy is important for gastric cancer. Endoscopic treatment has become the preferred treatment for patients with early gastric cancer. However, only when multiple disciplines is involved in the decision-making process, appropriate patients can be selected and benefit from the minimally invasive treatment. In China, 90% of gastric cancers are at advanced stage at diagnosis, which are associated with worse prognosis compared to early gastric cancer. The optimal treatment depends on the multi-disciplinary therapy including surgery, chemotherapy, radiotherapy, and molecular targeted therapy.
Combined Modality Therapy ; Humans ; Stomach Neoplasms ; therapy

BACKGROUND: Primary progressive aphasia syndrome(PPA) is an unusual type of dementia, and the relevant reports are very rare in China.OBJECTIVE: To describe a Chinese PPA patient with non-fluent aphasia as the main clinical characteristic.DESIGN: An observed trial and a case analysis based on patients.SETTING: Department of Neurology in a hospital of a university and a general hospital of a military area command of Chinese PLA.PARTICIPANT: The patient was a 64-year-old and right-handed man, who hospitalizated in First Clinical Medical College, Harbin Medical University in April 2002.METHODS: Neuropsychological assessment, head structural computed tomograph and magnetic resonance imaging and functional single photon emission computed tomography(SPECT) imaging were used in this patient.ing results.RESULTS: Neuropsychological testing revealed predominantly non-fluent aphasia, anomia was the earliest symptom. CT scan and MRI revealed atrophy of left temporal convexities and enlarged sylvian fissures. SPECT exhibited hypoperfusion in the left temporal, frontal, and partially parietal areas.CONCLUSION: The clinical symptoms, the neuropsychological and neuroimaging findings fit the diagnosis of PPA.

Adult ; Aged ; Colectomy ; Colonic Neoplasms ; pathology ; surgery ; Female ; Gastrectomy ; Humans ; Male ; Middle Aged ; Rectal Neoplasms ; pathology ; surgery ; Rectum ; surgery ; Stomach Neoplasms ; pathology ; surgery ; T-Lymphocyte Subsets ; pathology ; T-Lymphocytes, Cytotoxic ; pathology ; Th1 Cells ; pathology ; Th2 Cells ; pathology

AIM:To apply improved quality evaluation method for improving current quality criteria of Fufang Danshen products. METHODS:Considering both hydrophilic and lipophilic active components-danshensu,protocatechuic aldehyde,salvianolic acid B,cryptotanshinone and tanshinone ⅡA were selected as five markers. A HPLC method was developed to simultaneously determine their contents,which were used to compare the products from different companies,and different batches from the same company. Similarity factor method was used to evaluate the similarities of in-vitro dissolution profiles. Moreover,accelerated and long-term stability tests were performed to predict the shelf-life of Fufang Danshen products. RESULTS:All of the Fufang Danshen products passed the content requirements of Chinese Pharmacopeia. However,the content variations of the hydrophilic components were much higher than those of the lipophilic components. In dissolution tests,most of the hydrophilic components were dissolved completely while all of the lipophilic components could not be detected. The f2 values showed that there were no similar dissolution profiles among different brands of Fufang Danshen products. The contents of five markers degraded compatible with first-order kinetics processes in both the accelerated and long-term stability tests. The predicted shelf-life of Fufang Danshen products were shorter than those labelled on the products. CONCLUSION:It is suggested that more markers with defined content range instead of lower content limit are required for better control of Fufang Danshen products. Dissolution and stability tests need to be added into the quality control criteria in the Chinese Pharmacopeia.

OBJECTIVE To detect the genes of plasmid-mediated AmpC and ESBL ?-lactamases and classⅠ integron in clinical isolate of Escherichia coli.METHODS The bacterial susceptibility to antimicrobial agents for strain E50 was determined by agar dilution method.The genes of AmpC,ESBLs,and intⅠ1 were analyzed using PCR and verified DNA sequencing.Conjugation experiment was used to study the transfer of drug resistance.RESULTS The strain was only susceptible to imipenem.CTX-M-15,SHV-1,TEM-1,DHA-1 and intⅠ 1 genes were positive.CONCLUSIONS It has complicated mechanism of drug resistance.Some of clinical strains producing plasmid-mediated AmpC ?-lactamase are accompanied by extensively producing ESBLs.Carbapenems are the best choice for treatment infection caused by strains producing ESACs.More attention should be paid to integron which plays an important role in multi-resistance.

OBJECTIVE To ensure clinical application of standard procedure in the management of dental handpieces collection and sterilization.METHODS To establish the center of sterilization and supply for dental handpieces;to equip with the device for depuration and sterilization;to standardize the procedure for depuration,retrieval,pre-disposal treatment,cleaning,drying,lubrication,envelopment and sterilization.RESULTS The management of collection and sterilization for dental handpieces ensured the clinical application of standard procedure,avoided the exogenous infection and guaranteed the patients safety.CONCLUSIONS The clinical management of collection and sterilization for dental handpieces is an effective method.

Objective To analyze the immunization failure factors of 18 exposed rabies.Methods A statistical analysis factors is based on processing the exposed local wounds, the application of anti-serum, vaccines, wound area, incubation period, and compared to immune cases. Results Eighteen people, exposed immunization failure cases, scattered in the rural area(town). Thire age distribution is in all age groups during 2~83 years old and sex ratio of the men and women is 1:0.8.The short incubation period(28 days) accountered for 77.8%(14/18);Among by 61.5% people was bitten in neck accounter for 91.7%(10/12);Nine cases went to the village and town hospital to deal with the wound ,but only one case used rabies virus serums. Vaccines made in China are rat kidney(five cases) and refined Vero(8 cases), at the sane time the other five types made in China were unkown. Conclusions The most effective way to reduce the incidence of short incubation period is to strengthen management and immunization of animals such as dog, and to apply exposed former immunization in the epidemic area. At the same time, the key to reduce exposed immunization failure is exposed dealing in right ways, the muscle injection with anti-virus serums or immune globulin, and application of vaccine.

Objective To study a new technique (lung cancer diagnossing system, LCDS) based on the computer imaging and artificial neural network for early diagnosis of lung cancer, and evaluate it's value in early cytopathological diagnosis of lung cancer. Methods The cytological smears from the specimens obtained by Percutaneous Aspiration Lung Biopsy (PALB) in 512 cases were synthetically analyzed by LCDS. Among them, 362 cases received operations. The diagnoses by LCDS were compared with postoperative histopathological diagnosis. Results In cytopathological diagnoses for the 512 specimens, LCDS can judge between cancer cells and non-cancer cells from lung lesions with its image analysis and expert system. Moreover, it can distinguish squamous carcinoma, adenocarcinoma and small cell carcinoma in cytopathological diagnosis with built-in neural network. The total coincident rate of LCDS diagnosis was 91.80% compared with the pathological diagnosis. In the 362 cases, the sensitivity of LCDS diagnosis was 94.79% (291/307), the specificity was 90.91%(50/55), and the consistent rate was 94.20%(341/362). Conclusion The diagnostic pattern of LCDS was practical and effective. It has applicable value in cytopathological diagnosis of lung cancer and may be an efficient means for early diagnosis of lung cancer.