1.The study on core competency of cardiovascular specialist nurses in military hospitals
Jie QIN ; Lijuan ZHOU ; Ying LIANG
Chinese Journal of Practical Nursing 2013;(18):18-21
Objective To learn the status of core competency of cardiovascular specialist nurses in military hospitals in order to supply evidence to establish contrapuntal training protocol.MethodsThe Competency Inventory for Registered Nurse Scale (by LIU Ming) was distributed to investigate the core competency of 156 registered nurses.The data underwent analysis.Results The overall score of core competency level was (3.17±0.69),the highest mean score was the dimension of legal and ethical practice,and the lowest mean score was the dimension of critical thinking and nursing research apititude.the core competency varied with professional title and staffing.Evident difference existed in different dimensions and total scores.Conclusions The overall core competency is at the upper middle level for cardiovascular specialist nurses.They are competent enough to provide healthcare.The cultivation of nurses' critical thinking and nursing research ability should be strengthened.The nursing administrators should carry out pertinent training for nurses according to their different professional levels.
2.Practice and review of the construction of standardized medical resident training bases for the first batch of residents in Xinjiang
Shuya CHANG ; Jie QIN ; Hua YAO ; Ying LI ; Xiaowei HUANG
Chinese Journal of Medical Education Research 2016;15(10):1057-1065
Objective Through investigating the current situation of first national Standardized Medical Resident Training Bases construction in Xinjiang to provide the basis for the administrative department of public health to improve their resident training bases.Methods Selecting standardized training related personnel 133 people of 20 base hospital to conduct a questionnaire survey,and selecting the base hospit.al leaders,the management staff of functional departments,teachers and residents,a total of 254 people were given in-depth interviews.We conducted data collection mainly around the basic situation of the base hospitals and departments,to understand the basic situation,difficulties and problems of the standardized training of resident doctors in the base hospitals,and suggestions and opinions on the training work.We used x2 test,Wilcoxon rank test to make statistical analysis.Results Basic conditions of the hospital was not balanced,70% of the base hospital library number was 10 thousand ~5 million,75% of the base hospital computer had a volume of less than or equal to 30.There was statistical significance in the difference of the rate of operation between the cases and the skills in the southem/northeru region teaching/non professional teaching base hospital.Teacher level was not balanced,and only 5 hospital teacher training rate was greater than or equal to 80%,which met the national requirements.Enrollment of each department had a rising trend,including the department of pediatrics,psychiatry and other major shortage of profes-sional year by year,the increase in the proportion of 1 ~2 times.National financial aid was implemented,but lacked local financial input.Conclusion The balanced development of base construction,the continuous improvement of system construction and organization management,the improvement of the teachers' teaching and training quality,the improvement of the resident treatment and striving for more national and local financial allocation will be the focus of the construction and development of Xinjiang resident standardized training base.
3.The changes and significance in mRNA expressions of diaphragmatic cytoskeletal proteins and sarcoplasmic reticulum Ca~(2+)-ATPase in adriamycin-induced cytotoxicity in rats
Jie HU ; Ying YU ; Qin GAO ; Xudong GUAN
Chinese Pharmacological Bulletin 2010;26(2):244-247
Aim To observe the changes of diaphragm contractility and cytoskeletal proteins titin,nebulin and sarcoplasmic reticulum Ca~(2+)-ATPase gene expressions in adriamycin-induced cytotoxicity in rats.Methods The animal models of diaphragm damage were duplicated by injecting adriamycin into abdominal cavity one time.Forty male sprague-dawley rats were randomly divided into four groups(n=10):Three groups received adriamycin in low,middle and high dosage(10,20 and 40 mg·kg~(-1))respectively.Meanwhile,the normal saline was given to rats in control groups.Three days later,these rats were killed,and the diaphragm was removed by thoracotomy.The diaphragm contractility was assessed in isolated diaphragm strips perfusion by these paramemters including peak twitch tension(Pt),maximum tetanic tension(Po),time to peak contraction(CT),half relaxaion time(1/2RT),maximal rates of contraction(+dt/dt_(max))and maximal rates of relaxation(-dt/dt_(max)).The expressions of titin,nebulin and sarcoplasmic reticulum Ca~(2+)-ATPase(SERCA)at mRNA level were detected by RT-PCR analysis.Results In contrast to those in control group,Po,Pt,±dt/dt_(max) in the adriamycin group were lower(P<0.01);CT,1/2RT in the adriamycin group increased significantly(P<0.01).The levels of titin,nebulin and SERCA gene expressions in middle-dose group were lower than those in control group(P<0.01).Conclusions The mRNA levels of titin,nebulin and SERCA of diaphragm are down-regulated in adriamycin-induced cytotoxicity in rats.It may be associated with the decline of diaphragm contractility.
5.Effects of Interleukin-11 on Stimulate the Growth of the CEM Cell Line and the Antitumor Activities of Methotrexate
yue-qin, HAN ; yan-qin, HAN ; cai-jie, YUE ; li-ying, ZHOU
Journal of Applied Clinical Pediatrics 1993;0(03):-
0.05).Conclusions IL-11 unlikely to stimulate the growth of the CEM leukemia cell.And did not affect the antitumor effect of HD-MTX.It can be used as an assisting drug in program of acute lymphoblastic leukemia(ALL) therapy.
6.Preliminary Studies on Its Glycyrrhizinic Acid Metabolites of Endophytic Bacteria from Glycyrrhiza inflata Bat. of Xinjiang
Su-Qin SONG ; OTKURMAHMUT ; Shi-Jie FANG ; Mei-Ying GU ; Jing ZHU ;
Microbiology 2008;0(09):-
Total 149 strains of endophytic bacteria were isolated from different healthy organisms of Glycyrrhiza inflata Bat. from Xinjiang. The fermented liquids of these strains were screened by TLC and analysed by HPLC, and the glycyrrhizinic acid monoammonium salt was taken as standard control at the same time. Only one endophtytic bacterial stain of Bacillus subtilis could produce Glycyrrhizinic acid monoammonium salt analogue.
7.Changes and Significance of Serum High-Sensitivity C Reactive Protein and Platelet Parameter Levels in Newborns with Hypoxic-Ischemic Encephalopathy
ying, SHAN ; cheng-zhong, ZHENG ; jiong, QIN ; jie, NIU ; yang-ping, ZUO ; jia, HAO
Journal of Applied Clinical Pediatrics 2004;0(12):-
Objective To explore the changes of high-sensitivity C reactive protein(hs-CRP) and platelet parameter levels in newborns with hypoxic-ischemic encephalopathy(HIE)and its clinical significance.Methods Thirty-five infants with HIE and 16 healthy newborns were selected as study cases and controls respectively by automantc biochemistry analyzer.Serum hs-CRP content was measured by reaction rate method;Platelet parameter levels were detected by collecting blood samples from peripheral vascular of heel,and the activity of creatine kinase(CK),creatine phosphokinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),alpha-hydroxybntyric dehydrogenase(?-HBDH),alanine transaminase(ALT),aspartate aminotransferase(AST) were assayed as well.Results 1.The hs-CRP levels in newborns with HIE increased obviously in acute stage,and significant difference were observed compared with controls(P0.05).2.PLT in newborns with HIE decreased significantly in acute stage compared with that of controls(P0.05).3.The values of CK,CK-MB,LDH,?-HBDH,AST,ALT in newborns with HIE were significantly higher than those in controls in acute stage(P
8.Clinical Features of Juvenile Dermatomyositis
hai-feng, CHU ; yu-qin, CHU ; ying-jie, ZHONG ; shan-rui, ZHAO
Journal of Applied Clinical Pediatrics 2004;0(09):-
Objective To investigate the clinical manifestations and treatment regiment of children with juvenile dermatomyositis(JDM).Methods The clinical manifestation,changes of serum muscale enzyme,myopathic laboratory examination,treatment and prognosis of 15 children with JDM retrospectively admitted from Jan.1990 to Jan.2004 were analyzed.Results All of the children had symmetrical weakness of the proximal muscles.The most frequent features were heliotrope and Gottron's papules.Elevated muscle enzymes were noted in all cases.Electromyography revealed typical change of myopathic type and muscle biopsy was compalible with myositis in all cases.Most of patients achieved normal muscle enzymes within 1 month and had improved muscle strength with 2.5 monthes of the initiation of corticosteroid therapy.Conclusion It is very important to know the clinical features of JDM,and prompt diagnosis and treatment will result in an improved prognosis.
9.Outcomes appraisal of residents′ standardized training in Xinjiang
Yuge LI ; Ying LI ; Jie QIN ; Shuya CHANG ; Lijuan MA ; Lewen DONG ; Hua YAO
Chinese Journal of Hospital Administration 2017;33(9):668-671
Objective To learn the training effect and main influencing factors for residents′ standardized training in Xinjiang.Methods In the convenience sampling principle, 220 trainees subject to training at 10 training centers in Xinjiang were surveyed with questionnaire.Measurement indicators were described with frequencies and relative number, and x2 test was used to compare overall training outcomes among individual measurement indicators.Results Significant gaps were found among the respondents in terms of training outcomes.A comparison of six level-1 indicators and 25 level-2 indicators found that the respondents gave average comment to teaching and research training.Logistic regression analysis identified education (x2=7.575,P=0.006) and hospital (employer) or school (x2=10.770,P=0.001) as the main influencing factors for training outcomes.Conclusions The standardized training of residents in Xinjiang calls for greater improvement, namely enhanced leadership and powerful assurance mechanism, scientific planning, appraisal regulations and motivation mechanism, as well as encouraging academic environment.
10.Comparsion of pathological differences between cervical high-grade intraepithelial lesions positive resection surgical margin after cold knife conization and hysterectomy
Yan QIN ; Jie TIAN ; Xiaoyan LIU ; Ying CHEN ; Juhua FAN ; Kaixian DENG
Chinese Journal of Clinical and Experimental Pathology 2017;33(1):35-37
Purpose To compare the pathological differences between cervical high-grade intraepithelial lesions (CHGIL) positive resection surgical margin after cold knife conization and total hysterectomy,and to explore how to take further clinical treatment measures.Methods The pathologic results of 74 patients with CHGIL positive surgical margin after cold knife conization and hysterectomy were analyzed retrospectively.Results There was a correlation between positive cervical incision margin and residual uterine lesion (P < 0.01).Age,menopause status,gland involvement did not related to residual uterine lesions(P > 0.05).There was significant correlation between the lesion-related quadrant and the residual rate of uterine lesion (P < 0.01).Conclusion Cold knife conization and hysterectomy are safe and effective treatments for CHGIL.However,for the positive resection surgical margin after cold knife conization cases,hysterectomy should be carefully chosen and may choose conservative treatment or re-cone cutting.