1.Progress on chromosome 22q11 deletion syndrome
International Journal of Pediatrics 2010;37(3):237-240
Chromosome 22qll deletion syndrome(22q11DS) is a common chromosomal microdeletion syndrome. Its clinical manifestation is complex, comprising congenital heart disease, dysmorphic facial, immunodeficiency, endocrine dysfunction and so on. The syndrome has a population prevalence of approximately 1/2500-1/4000. There have been many recent advances in understanding of the clinical manifestation, behavior and psychiatric problems and the mechanisms leading to the specific phenotypic features in chromosome 22q11 deletion syndrome. Asymmetric recombination of homologous low copy repetitives in the deletion region causes the deletion of 22q11. TBX1 is the dominant gene contributing to the phenotype.
2.Double primary carcinoma of rectum: a case report.
Chinese Journal of Pathology 2006;35(7):431-431
Adenocarcinoma
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metabolism
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pathology
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Aged
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Carcinoid Tumor
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metabolism
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pathology
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Chromogranin A
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metabolism
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Humans
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Immunohistochemistry
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Male
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Neoplasms, Multiple Primary
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metabolism
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pathology
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Phosphopyruvate Hydratase
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metabolism
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Rectal Neoplasms
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metabolism
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pathology
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S100 Proteins
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metabolism
4.Application of daclizumab as an immune induction therapy after liver transplantation
Chinese Journal of Tissue Engineering Research 2013;(31):5601-5606
BACKGROUND:Daclizumab can be special y combined with the inerleukin-2 receptor on the surface of activated T cells in human body, and this method can reflect the close of interleukin-2 receptor thus inferring the effect of induction therapy. At present, the daclizumab has been widely used in renal transplantation, but there is no consensus on its clinical application in liver transplantation. OBJECTIVE:To investigate the expression of serum CD25+T cells and soluble interleukin-2 receptor in the patients receiving daclizumab for liver transplantation during perioperative period. METHODS:A total of 58 patients received orthotopic liver transplant for the first time were included and then the patients were randomly divided into two groups:control group (n=28) and treatment group (n=30). The patients in the two groups were treated with tacrolimus, mycophenolate mofetil and corticosteroids triple immunosuppressive regimen. The patients in the treatment group received immune induction therapy with daclizumab, and the patients in the control group did not receive daclizumab. RESULTS AND CONCLUSION:Flow cytometry and enzyme-linked immunosorbent assay showed the expression levels of CD25+T cells in the treatment group were significantly lower than those in the control group at different time points after liver transplantation (P<0.01);and the expression levels of soluble interleukin-2 receptor in the treatment group were lower than those in the control group during transplantation and at the first day after transplantation (P<0.05, P<0.01). At 6 months after transplantation, the incidence of acute rejection was decreased in the treatment group (P<0.01). The results indicate that daclizumab can effectively suppress the expression level of CD25+T cells, as wel as the expression level of soluble interleukin-2 receptor in the peripheral blood in the early stage of liver transplantation, thus effectively reducing the rate of acute rejection.
5.Features of Nutrition Metabolism in Patients with Cirrhosis and Nutritional Treatment in Hepatic Encephalopathy
Chinese Journal of Gastroenterology 2014;(9):513-516
Because of insufficient intake,synthesis disorder,metabolic disorder and excessive consumption,patients with cirrhosis often lead to malnutrition. Providing scientific nutritional support and guiding the patients to a reasonable diet can effectively improve the liver metabolism and reduce the complication of cirrhosis such as hepatic encephalopathy,and improve the quality of life and survival rate. This article described the nutritional metabolism disorder in patients with cirrhosis and nutritional treatment in hepatic encephalopathy.
6.Determination of 10 Kinds of Phthalates in Cosmetics by High Performance Liquid Chromatography
Journal of Environment and Health 1992;0(04):-
Objective To establish a high performance liquid chromatography method for simultaneous determination of 10 kinds of phthalates in cosmetics. Methods 10 kinds of phthalates were separated on a C18 column using methanol-water as mobile phase at a flow rate of 1.0 ml/min, 25℃ column temperature and 280 nm detection wave. Results The detection limit of 10 kinds of phthalates were 0.1-7 mg/L. The precision was less than 3.95% and recovery rates varied from 98.59% to 108.07%. Conclusion The experimental results show that the method is simple, precise and accurate and suitable to simultaneous determination of 10 kinds of phthalates in cosmetics.
7.Laparoscopic cholecystectomy for acute cholecystitis:a report of 272 cases
Chinese Journal of General Surgery 1993;0(02):-
Objective To explore the operation methods,intraoperative treatment,measures for prevention and treatment of complications of laparoscopic cholecystectomy(LC) for acute cholecystitis.Methods Two hundred and serenty-two patients with acute cholecystitis from March 2003 to April 2007 were analyzed retrospectively.We performed total laparoscopic cholecystectomy in 260 cases and subtotal laparoscopic cholecystectomy with cholecystomucoclasis of remnant gallbladder in 12 cases.Results None of 272 cases was converted to open operation.There was no mortality,and no bile duct injury or major bleeding.Conclusions Laparoscopic cholecystectomy is a safe and effective method for acute cholecystitis and it has the advantages of minimal trauma,quick recovery and less blood loss.
8.Comparison and Analysis on Instructions for Foreign and Domestic Levonorgestrel Emergency Contraception
China Pharmacy 2001;0(09):-
OBJECTIVE:To provide reference for the standardization of the instruction of levonorgestrel emergency contraception. METHODS:Instruction of levonorgestrel emergency contraception in the market was compared with the national regulations and foreign instruction of the same kind of productions in order to discover the problems in domestic specification. RESULTS:The major problems of domestic instruction of levonorgestrel emergency contraception included instructions without population limits, unclear frequency and interval of drug use,without attention to ADR of levonorgestrel emergency contraception,lack of pharmacy research data. CONCLUSIONS:The problems existing in domestic instruction of levonorgestrel emergency contraception are shortage of items and warnings of drug safety. Related administration departments and enterprises are suggested to modify and perfect the instruction of levonorgestrel emergency contraception.
9.Features and prevention of central venous catheter infection in patients undergoing digestive tract surgical procedures
Chinese Journal of General Surgery 1997;0(04):-
Objective To discuss the features and prevention of central venous catheter infection in patients undergoing digestive tract operation.Methods The clinical data of 145 patients with central venous catheters after G1 surgery in our hospital from March 2004 to March 2009 were retrospectively analyzed.Results Among the 145 cases with central venous catheters,40 cases(27.6%)presented with defite catheter related infection and 56 strains of pathogens were isolated and cultured.Of the 56 isolates,28(50%) were of gram-negative bacteria,22(39%) of gram-postive bacteria and 6(11%) of fungi.Six cases suffered from multiple catheter infection(15%),39patients were cured and 1 died.Conclusions Gram-negative bacteria are the most common pathogens for central venous catheter infection in GI operated patients.It is crucial that standardized card of intravenous infusion should be implemented and prophylactic antibiotics should properly be selected for control of enterogenous infection.
10.Detection of Urinary Podocyte Marker Protein and Its Value on Diagnosis of Kidney Disease
Journal of Applied Clinical Pediatrics 1992;0(05):-
ObjectiveTo explore the clinical value on the detection of urinary podocyte marker protein podocalyxin(PCX) in children with nephritic syndrome(NS) and Schonlein-Henoch purpura nephritis(HSPN).MethodsUrinary samples voided in the morning were obtained from 14 healthy children and 75 children with NS or HSPN or Schonlein-Henoch purpura(HSP),including 21 children with NS in the acute phrase,14 children with NS in the catabasis,16 children with HSPN in the acute phrase,14 children with HSPN in the catabasis,10 children with common HSP,and 14 healthy children for control group.And urinary PCX content of the first morning urine was quantified by enzyme-linked immunosorbent assay(ELISA).SPSS 13.0 software was used to analyze the data.Results1.The levels of PCX content were significantly higher in the urine from children with any case of NS and HSPN compared with those in the control group(P≤0.009),but there was no obvious difference between common HSP children and children in the control group(P=0.754).2.The level of urinary PCX content in acute phrase of NS was(0.593?0.271) ?g/L,in the catabasis of NS was(0.162?0.093) ?g/L,there were significant difference(P=0).The level of urinary PCX content in acute phrase of HSPN was(1.822?1.342) ?g/L,in the catabasis of HSPN it was(0.236?0.141) ?g/L,which was significantly different(P=0.004).The level of urinary PCX content in common HSP was(0.089?0.061) ?g/L,there were significant difference in any case of HSPN(Pa