Anthropometry ; Child ; Child Nutritional Physiological Phenomena ; Child, Hospitalized ; Critical Care ; methods ; Critical Illness ; Enteral Nutrition ; Humans ; Infant ; Intensive Care Units, Pediatric ; Malnutrition ; diagnosis ; prevention & control ; Nutrition Assessment ; Nutritional Status ; Parenteral Nutrition ; Predictive Value of Tests

Aquaporins (AQP) are membrane channel proteins which facilitate water transport through cell membranes.AQP4 is abundantly expressed in brain which is located in endfeet of astrocytes adjacent to capillaries,neurons,and neuronal synapses.It has also been identified in neurons of the supraoptic and paraventricular nuclei of the hypothalamus.AQP are closely related to many central nervous system diseases.Researches have showed that AQP4 participates in regulating and controling process of cerebral edema that caused by brain trauma,cerebral ischemia,intracranial infection and mmour,etc.AQP4 antibody is specific biological markers in serum of patients with neuromyelitis,which helps diagnosis of neuromyelitis optica and multiple sclerosis,predicting prognosis and therapy of neuromyelitis optica.AQP4 has been shown to play roles in pathological and physiological process of neurodegenerative diseases,epilepsy,migraine.This article aims to review the distribution,function,influential factors of AQP4 and research development of AQP4 in common diseases of the central nervous system.

OBJECTIVE: To establish HPLC fingerprint of Compound danshen tablets.METHODS: The separation was performed on Agilent Eclipse XDB-C18(150 mm?4.6 mm,5?m) column with mobile phase consisted of acetonitrile-0.04% phosphate (gradient elution) at flow rate of 1.0 mL?min-1.Detection wavelength was set at 272 nm and column temperature was 30℃.RESULTS: Established HPLC fingerprint was distinct and reproducible.There were 8 characteristic peaks among which No.5 characteristic peaks,No.6,No.7,No.8 came from HPLC fingerprint of Salvia miltiorrhiza and No.1 characteristic peaks,No.2,No.3,No.4 came from HPLC fingerprint of Panax notoginseng.CONCLUSION: The characteristic peaks of effective parts of Compound danshen tablet mainly come from S.miltiorrhiza.The study can be used for tracing and isolation of effective part of Compound danshen tablet and establishes basis for the further development of Chinese patent drugs.

ObjectiveTo obtain data related to various periods of acupuncture treatment for rat focal ischemia and reperfusion and infer the optimal time point of acupuncture treatment by examining cerebral ROCK expression on the ischemic side in different periods of acupuncture for rats with focal ischemia and reperfusion.MethodOne hundred andeighty male adult Wistar rats were enrolled and randomly allocated to blank, sham operation, model and acupuncture groups. The model and acupuncture groups were separately divided into 5 subgroups: the 6 h, 24 h, 48 h, 72 h and 2 w subgroups. There were atotal of 12 groups, 15 rats each. An animal model of focal cerebral ischemia was made using a thread occlusion method for obstructing rat right middle cerebral artery. The carotid artery was only separated in the sham operation. Materials were taken in the blank and sham operation groups on day 2 after model making. Materials were taken for examination in every subgroup of the model group at 6, 24, 48 and 72 hours and 2 weeks after model making. Materials were taken for examination after acupuncture at Baihui(GV20), Dazhui(GV14)and Zusanli (ST36)in every subgroup of the acupuncture group at 6, 24, 48 and 72 hours and 2 weeks after model making.ResultAcupuncture markedly improved neurological deficits in rats with cerebral ischemia and reperfusion. Areduction in the neurological deficit score was largest in the 6 h acupuncture group and there was a statistically significant difference compared with the other acupuncture groups (24 h, 48 h and 72 h) (P<0.05). There was no statistically significant difference in ROCK expression between the sham operation and blank groups (P>0.05). There was a statistically significant difference in ROCK expression between the model (ischemia-reperfusion 6 h, 24 h, 48 h and 72 h) and blank groups (P<0.05). ROCK expressionreached the peak value at 6 hours after ischemia and reperfusion. There was a statistically significant point-to-point difference in ROCK expression between the acupuncture (ischemia-reperfusion 6 h, 24 h, 48 h and 72 h) and model (ischemia-reperfusion 6h, 24 h, 48 h and 72 h) groups (P<0.05). ROCK expression was down-regulated most markedly in the ischemia-reperfusion 6 h acupuncture group.Conclusion Acupuncture has an inhibitory effect on Rho/Rock in a rat model of cerebral ischemia and reperfusion. Six hours after ischemia and reperfusion is the optimal time point of acupuncture treatment. Acupuncture at that time can protect and improve post-ischemic injured brain tissue to the largest extent.

Objective To observe the effects of hyperbaric oxggenation (HBO) on liver blood flow, hepatic functions and the changes of clinical manifestations in patients with chronic hepatitis. Methods Thirty two patients with chronic hepatitis (HBO group) were treated with HBOThe changes of blood flow of the right branch of portal veinin HBO group were and hepatic functions were measured. Results After HBO, hepatic functions were significantly improved, and the blood flow of the right branch of portal veinwas was increased as compared with that before the treatment(0.318?0.101 L/min vs 0.378?0.102 L/min, P

With the development of income per capita,"high personal medical expenditure" shows the wider of disease risk,which is resulted from the increasing medical payment and imperfect risk pooling.The former that is related with the excess delivery of advance medical technology and drug has been a dominating reason since 1980.And the imperfect risk pooling means the imperfect social medical insurance,of which the government should take charge.However,influenced by the reform policies of the economic systems,similar to all the transitional economies reducing the government role in healthcare financing,China has put an increasing emphasis on the payroll tax-based social insurance system and out-pockets payment,moving away from a predominantly general revenue-based financing system under the old command economy.In a conclusion,the Chinese Government should make clear the financing function,and replace fee-for-service(FFS) payment according to the distorted pricing system with aggregated pre-payment for patients covered by social insurance to mitigate the incentive for cost escalation.Meanwhile,the target of the new medical reform that should resolve the problem of high personal medical expenditure is demanding and perfecting the social medical insurance with wider risk pooling.

Objective: To explore the effect of the application of ICQ technology in constructing a harmonious environment for nursing staff.Method: The Internet,support from Tencent network,ICQ technology are employed to conduct on line communication among nursing staff.Result: the Working and interpersonal connection environment is remarkably improved by the application of ICQ technology,thus it is of great significance in constructing a harmonious relation among nursing staff and enhancing medical service quality.

0.05 ), bacterial clearance were 100% and 90%, and adverse reaction rates were 10%(2/20)and 10.53 % ( 2/19 ), respectively. All those adverse reactions were mainly gastrointestinal tract reactions. The abnormality of laboratory inspections associated with trial drugs happened to 4 and 5 patients in two groups. The reactions were mostly light increase of aminotransferase without effect on therapy. CONCLUSION: Gatifloxacin is an antibiotic with large antimicrobial spectrum and can be recommended to treat light to moderate acute lower respiratory tract infections.

Dendritic spines are functional protrusions on neuron dendrites and formation of excitatory synaptic sites.Dendritic spines contain a variety of cell surface receptors,actin cytoskeleton,scaffolding proteins and other components,which regulate the growth of dendritic spines maturation and structure.Multiple components within dendritic spines not only have effects on expression of its shape and structure,but also on the function.Morphology of dendritic spines is closely related with its function.Its shape is affected by many factors in the changing process.So dendritic spine plasticity is an important aspect of synaptic function in the central nervous system,and is closely related with learning and memory function and central nervous system diseases.

ObjectiveTo discuss the infiuence of personalized nursing intervention on success rate of holding breathing in patients undergoing dual-source CT imaging.Methods167 cases of patients were randomly divided into the observation group(100 cases)and the control group(67 cases). The control group implemented routine care, on the basis of routine care, the observation group was given pertinent and individualized nursing intervemion according to the factors causing failure of holding breathing, including better psychological counseling for patients, the right guidance, to alleviate symptoms, to improve comfort degree, to give clinical evaluation after inspection, et al.ResultsThe success rate of holding breathing in the observation group and the control group was 99.0％ and 88.1％, the observation group was significantly higher than the control group.ConclusionsHealth education for patients, attention to patients' illness, mental state, cognitive and behavioral changes in a timely manner to give individualized nursing intervention and seriously check the implementation of results in patients, can effectively improve the success rate of holding breathing in patients undergoing dual-source CT coronary angiography.