Objective To explore the application of Orem self-nursing theory on patients under nursing after uterine neck cancer operation.Methods 90 patients after uterine neck cancer operation were randomly divided into two groups.45 cases as observation group and 45 cases as control group.The patients in the control group use normal nursing and common health education after uterine neck cancer operatlon;the observation group applies Orem selfnursing theory to assess the patients' nursing ability and uses different nursing system and personality health education knowledge for the promotion to let the patients to participate in the nursing activity based on the situation.Results Activity time after out of bed,gas releasing time of anus in observation group are evidently earlier than that of the control group,also have vomit and abdominal distension digestion system symptom decrease after the patients operation;the urethra infection and retention of urine rate are significantly lower than that of the control group and the difference is remarkable(P < 0.05 ).Conclusion The Orem self-nursing theory are used in nursing of patients after uterine neck cancer operation to facilitate the recovery of health after patients operation so as to relieve the burden of family and society and improve quality of living of patients.

Objective:To investigate the the retention force changes of 2 kinds of T bar clasps on Cr-Co crowns and the surface ab-rasion of the crowns.Methods:Standard Cr-Co crowns were made,and standard T bar clasps were made of Cr-Co alloy and Vitalli-um2000 with 0.25 mm and 0.5 mm undercut depth respectively.1 800 times repeated placement and removal(fatigue test)were car-ried out on instron testing machine in or without saliva soak condition.The attenuation curves of the maximum retention force was an-alysed.The surface abrasion of the crowns was observed before and after the fatigue test by SEM.Results:The retention force attenu-ation of the clasps in every group was accord with the logarithm attenuation law.SEMexamination showed that in the same condition, there was less surface abrasion in Vitallium2000 group than that in Cr-Co group.Vitallium2000 clasp was superior to Cr-Co clasp in maintaining the retention force.Conclusion:Vitallium2000 T bar clasp may provide better retention force with less furface abrasion on Cr-Co crown than Cr-Co clasp.

The cell-impedance substrate sensor,which is mainly used to detect the shapes and function ofcells and other micro.organism.is a novel tool based on the technique of BIOMEMS to study the cellular physiologyand clinical Dharmasology.It has drawn attention from both domestic and international scholars as well as compa nies in recent years for its advantages such as innovative design and long-term non-invasive monitoring.This paperintroduces the interfacial model of cell-sensor in detail and gives a sketch of the recent international researchprogress.Then the novel interdigitated array,which was designed in our group recently,is introduced.The fore ground of development is discussed in the end.

To discuss the distribution of patents' holders for Chinese herbal compounds in treating cardiovascular and cerebrovascular, the patents' holders for Chinese herbal compounds in treating cardiovascular and cerebrovascular were cluster analyzed by means of simple statistics and cluster analysis. Clustering variables were composed of patent applications, patent maintained number, related papers' quantity, etc. Chinese herbal compound patents' holders were divided into four categories according to their different scientific research and patent strength. It is the magic weapon for Chinese herbal compound patents' holders that have scientific research patents' transforming and make coordination of patent protection and scientific innovation.
Biometry ; Cardiovascular Diseases ; drug therapy ; Cerebrovascular Disorders ; drug therapy ; Cluster Analysis ; Drugs, Chinese Herbal ; economics ; therapeutic use ; Herbal Medicine ; economics ; legislation & jurisprudence ; manpower ; statistics & numerical data ; Humans ; Medicine, Chinese Traditional ; economics ; Patents as Topic

Fluke Electrical Safety analyzer (ESA-601) and Electrical Surgery analyzer(Model 454A)are used to measure some relative parameters of radio knife. By combining our measuring activity with the problems existing in the daily managements and usage of radio knife,our viewpoints are described in the following four aspects:management rules,electric shock prevention,patient electrode system and output power. An immature scheme about the quality control of radio knife is also put forward.

Objective To screen and identify the anomously expressed proteins at protein level in colon mucosa of diarrhea-predominant irritable bowel syndrome(D-IBS)patients and healthy individuals.Methods Four D-IBS patients and four healthy individuals were included in the study.Biopsies of mucosa at the ileocecal junction and sigmoid colon were performed via colonoscopy.The specimens were cleaned with ice cold saline which contained 0.1% PMSF,and were snap frozen in liquid nitrogen.The two-dimensional gel electrophoresis(2-DE)was used to screen the anomously expressed proteins,and the two proteins which presented the greatest changes in each group were identified by mass spectrometry method.Results Proteomics maps of human colon mucosa were obtained successfully with 2-DE.Average protein spots were 336 in normal control group,and the matching rate among them was 92%,while in D-IBS group,the average protein spots were 426,and the matching rate was 95%.The average matching rate between the test group and the control group was 74%.It was found that the volume value of 24 proteins spots changed more than two folds.The protein expression was found to decrease in 3 spots and increase in 21 spots.Four proteins were chosen for analysis with mass spectrometry analysis.The two up-regulated proteins were identified as Immunoglobulin J chain and heat shock protein 27,while the other two down-regulated proteins were identified as hemoglobin beta subunit and fructose-bisphosphate aldolase A.Conclusion With 2-DE,proteomics maps of human colon mucosa have been obtained successfully.The proteome expressions of colon mucosa in D-IBS patients are remarkably different from that of the healthy individuals.The four identified proteins may play a certain role in the pathogenesis of D-IBS.

Objective:In order to improve the quality of standardized residency training in a tertiary hospital in Beijing, and to establish a multi-dimensional evaluation system based on post competency and professional accomplishment.Methods:The residents trained in our hospital were evaluated by questionnaires sent by third parties from the five aspects of evaluation by patients, peers, nurses, superiors and themselves. In this paper, SPSS 24.0 software was used to analyze the reliability and validity of the multidimensional evaluation scale. The evaluation results were analyzed by ANOVA and Pearson correlation analysis.Results:The hospital met the requirements for the post competency and professional accomplishment of the residents, and the overall level was good. However, the teamwork ability of some residents, especially the medical communication still needs to be improved.Conclusion:This study has enabled residents to pay more attention to the development of daily post competencies and professional accomplishment behaviors. It has provided an example basis for the further development of standardized residency training in the hospital, and carried out preliminary exploration for the design of training modules.

Objective: To investigate the compliance of functional exercises and identify its influencing factors among young and middle-aged stroke patients, so as to provide insights into rehabilitation management among young and middle-aged stroke patients. Methods: Stroke patients at ages of 18 to 59 years were recruited from those receiving rehabilitation treatment in Tongde Hospital Affiliated to Zhejiang Chinese Medical University from January 2021 to June 2022. Participants' demographics and clinical data were collected through questionnaire surveys. The compliance of functional exercises was assessed using Stroke Functional Exercise Adherence Questionnaire, and patients' social support, exercise self-efficacy and depression were assessed using the Social Support Rating Scale, Exercise Self-efficacy Scale and Self-rating Depression Scale. The factors affecting functional exercise compliance were identified among young and middle-aged stroke patients with a multivariable linear regression model. Results: A total of 230 questionnaires were allocated and 213 valid questionnaires were recovered, with an effective recovery rate of 92.61%. The respondents included 129 men (60.56%) and 84 women (39.44%) and had a mean age of (53.49±7.95) years. The total score of functional exercise compliance was (41.37±9.11) points among the participants. Multivariable linear regression analysis identified education level (β'=0.376), monthly household income per capita (β'=0.309), history of stroke onset (β'=-0.238), rehabilitation instruction (β'=0.284), depression (β'=-0.261), exercise self-efficacy (β'=0.152), and social support level (β': 0.277 to 0.415) as factors affecting the functional exercise compliance among young and middle-aged stroke patients. Conclusion Education level, income, history of stroke onset, depression, exercise self-efficacy and social support may affect the compliance of exercise compliance among young and middle-aged stroke patients.

Background Laser peripheral iridotomy(LPI) is used as the primary therapy for the eyes at risk of angle closure.But there are still 28% eyes with primary angle closure suspect occur angle closure within 2 years after LPI.It is necessary to explore the associated factors of the efficacy of LPI.Objective The aim of this study was to explore the changes of intraocular pressure(IOP) and anterior chamber angle in the fellow eyes of patients with unilateral acute attack of primary angle closure glaucoma (PACG) and analyze the relevant factors influencing the successful rate of LPI.Methods Eighty-seven fellow eyes received LPI from 87 patients with unilateral acute attack of PACG were included in this study and retrospectively analyzed.The IOP and gonioscopy were performed before and 1 week,3,6,9,12 months after LPI.Successful signs of LPI were defined as an IOP 6-21mmHg without any anti-glaucoma medication,none of glaucomatous neuropathy and the coincident visual field loss,and no need of additional glaucomatous medication or surgery.This study was approved by Ethic Committee of the First Hospital of Xinxiang Medical College,and written informed consent was obtained from each patient.Results Seventy-nine eyes of 79 cases finished the medical visit throughout the follow-up duration with the age 61.4±0.4 years and 33(41.8%) males and 46(58.2%) females.The mean IOP was lowed in various time points after LPI in comparison with before operation with the general difference among different time visiting groups(F=4.056,P＜0.01).Shaffer grade was increased in superior,temporal and nasal quadrants and significant differences were found between 1 week group,3 months group or 6 months group and before operation group (P＜0.05).LPI lessened the range of appositional angle closure (AAC) in postoperative 1 week group and 3 months group compared with pre-operative group (P＜0.05),but no statistically significant reduce was seen in range of AAC from 6 months through 12 months after LPI in comparison with pre-operation (P＞0.05).LPI was determined as successful in 61 cases (77.2%) during one-year fellow-up period.Several variables,such as preoperative IOP,Shaffer grade of each quadrant,mean Shaffer grade and the extent of AAC,were significantly different between LPI success and failure group(P＜0.01).Cox stepwise regression analysis found that the success rate was significantly associated with the extent of AAC (Wald=48.150,RR=1.963,P＜0.01) rather than pre-IOP,Shaffer grade of each quadrant,mean Shaffer grade,age and gender (P＞0.05).Conclusion LPI can widen the anterior chamber angle and low IOP in the fellow eyes of PACG attack eyes.The success rate of LPI is associated with the extent of pre-AAC,suggesting that it is necessary for LPI in consideration of the extent of pre-AAC.

OBJECTIVE:To study the percutaneous properties of Man-PEI25k nanocomplex under the treatment of microneedles. METHODS:Using fluorescent dye water-soluble carboxyl CdSe/ZnS quantum dot (QD) as model drug, Man-PEI25k/QD and Man-PEI25k/QD nanocomplex with different grafting rates(1∶3,1∶6)were formed through electrostatic adherence with PEI25k and Man-PEI25k. The distribution of QD in the active epidermal layer and dermis of skin were observed by confocal microscopy after the treatment of microneedles,using free QD as control. The accumulative retention amounts of QD in the active epidermal layer and dermis of skin were determined by fluorescence spectrophotometer after PEI25k/QD and Man-PEI25k/QD nanocomplex treated with mi-croneedles. RESULTS:The amounts of Man-PEI25k/QD nanocomplex in active epidermal layer and dermis were significantly higher than that of PEI25k/QD nanocomplex under the treatment of microneedles in vivo;the amounts of Man-PEI25k/QD (1∶6) nanocom-plex in active epidermal layer and dermis of skin were significantly higher than that of Man-PEI25k/QD(1∶3)nanocomplex. In in vi-tro transdermal diffusion experiments,microneedles could increase the retention amounts of nanocomplex in active epidermal layer and dermis of skin significantly. The retention amounts of Man-PEI25k/QD nanocomplex in active epidermal layer were increased by 2 times of that of PEI25k/QD under the treatment of microneedles after 48 h;at the same time,in the dermis that was increased by 1.5 times,with statistical significance (P<0.01). CONCLUSIONS:Microneedles can improve the percutaneous properties of Man-PEI25k nanocomplex in active epidermal layer.