Cancer-testis antigens (CTAs) are protein antigens with normal expression restricted to adult testis and yet are aberrantly activated and expressed in a proportion of various types of tumor tissues. The expressions of CTA correlate with tumor staging, histopathological subtype, recurrence and metastasis in nonsmall cell lung cancer. CTAs are immunogenic in lung cancer patients and have a good prospect in lung cancer Immunotherapy.

Objective To explore the application value of color Doppler ultrasound in diagnosis of intrahepatic artery aneu-rysms.Methods Thirty-six cases of intrahepatic artery aneurysm was diagnosed by color Doppler ultrasound.And the data were analyzed retrospectively.Results In the 36 cases of hepatic artery aneurysm,1 7 cases were located in the left lobe of liver,13 cases were located in the right lobe of liver,and 6 cases were located in the left and right hepatic lobe.A total of 27 cases were solitary, 6 cases were 2 aneurysm,and 3 cases were 3 and above aneurysm.Maximum was 28 mm×27 mm,and minimum was 8 mm×7 mm. There are 3 cases with mural thrombus.Liver oval cystic echo free zone was found by two-dimensional ultrasonography.The bound-ary was clear.The wall was smooth and thin.The rear echo was strengthened.The pulsatile red,blue single color flow signal(n=1 5)or vortex like red and blue color flow signal(n=21)were showed by color Doppler ultrasonography.The hepatic artery blood flow velocity spectrum was 12-29 cm/s,and resistance index was 0.60-0.68.Conclusion Color Doppler ultrasonography was the preferred imaging methodology of early screening and diagnosis of intrahepatic artery.

Objective To explore the correlation between nurses' job burnout and social support and the source of job stress. Methods 138 doctors and 162 nurses from 4 general hospitals were investigated by different questionnaires. The nurses were investigated by Maslach Burnout Inventory(MBI),perceived social support scale(PSSS)and Chinese nurse job stress source scale. While the doctors only underwent investigation using Maslach Burnout Inventory (MBI).The results were collected and analyzed. Results The MBI results showed that the scores of emotional exhaustion and non-humanity were apparently higher, while the score of sense of working achievement was lower in nurses than those in doctors. The level of job burnout in nurses was higher than that of doctors with statistical difference. The score of social support was lower and the score of source of job stress was higher in nurses with increased level of job burnout than those with decreased level. Conclusion The status of nurses' job burnout should cause the attention of nursing managers. Prompt and selective measures should be adopted to improve the psychological health of nurses.

Objective To investigate the influence of social support on work-family conflict and psychological control ability of nurses. Methods 126 women nurses from four general hospitals by the method of random cluster sampling were divided into two groups according to the scores of the social sup-port scale(SSRS). Nurses with score lower than 35 were set as low social support group(totally 38 nurses), nurses with score higher than 45 were named as high social support group(46 nurses).The two groups were assessed by SSRS, work-family conflict scale (WFCS) and IPC respectively. The results underwent stati-s-tical analysis with t test, χ2 test and Pearson correlation analysis. Results The age and nurses' work-ing age in high social support group were significantly higher than that of the low social support group, the to-tal score of WFCS,the time,pressure and behavior score of subscales in high social support group were sig-nificanfly lower than that of the low social support group. The internality was higher, while the power-ful others and chance were lower in high social support group than those of low social support group. SSRS was negatively correlated with all factors of WFCS, positively correlated with internality factor of IPC, neg-atively correlated with powerful others and chance factors of IPC. Conclusions The nurses with high SSRS have low work-family conflict score and strong psychological control ability, so we should strengthen the social support of nurses.

Health Promotion ; organization & administration ; Humans ; Occupational Health ; Occupational Health Services ; organization & administration ; Risk Assessment

OBJECTIVE: To explore the association of XRCC3 gene polymorphisms and haplotypes with laryngeal. METHOD: We selected 4 tag SNPs (rs12432907, rs861536, rs861537, rs861531, rs861531) for the present study. 310 laryngeal patients and 310 healthy control subject were genotyping. The distribution of genotypes and haplotypes in these two group was compared. RESULT: The distributions of rs12432907 was significantly different between these two groups. The CCAG haplotype frequency was higher in laryngeal group than that in control group. But TCAG and TTAG haplotype frequency was were lower in the laryngeal patient than that those in the control subject. CONCLUSION XRCC3 gene polymorphism was associated with the risk of laryngeal patients.
Case-Control Studies ; DNA-Binding Proteins ; genetics ; Genotype ; Haplotypes ; Humans ; Laryngeal Neoplasms ; genetics ; Polymorphism, Single Nucleotide

To compare the clinical efficacy and safety of atomization inhalation of epinephrine combined with budes-onide and dexamethasone in the treatment of children with acute laryngitis. Methods:Totally 68 cases of children with acute laryngitis were randomly divided into two groups. The two groups were given the conventional therapy, and 30 cases in the control group were giv-en dexamethasone inhalation additionally, and the treatment group was given epinephrine combined with budesonide inhalation addition-ally. The clinical effect in 12, 24 and 72h, clinical symptom disappearance time and adverse reactions in the two groups were ob-served. Results:The clinical effect of the treatment group in 12, 24 and 72h was better than that in the control group. 72h after the treatment, 17 cases in the control group were cured, and the curative rate was 56. 67%, while 27 cases in the treatment group were cured with the curative rate of 71. 05%. The disappearance time of dyspnea and stridor, barking cough, hoarseness and the other clini-cal symptoms in the treatment group was significantly shorter than that in the control group, and the difference was statistically signifi-cant (P<0. 05). The two groups had no obvious adverse reaction. Conclusion:The clinical effect of the combination of epinephrine and budesonide inhalation in the treatment of children with acute laryngitis is better than that of dexamethasone inhalation, and the combination is safe and effective, which is worthy of clinical application.

Objective To discuss the clinical nursing care for liver abscess patients treated by indwelling drainage tube after puncture under ultrasonic guidance.Methods 64 liver abscess patients with diameter of the abscess longer than 5cm were treated by indwelling drainage tube after puncture under ultrasonic guidance,clinical nursing care was performed before and after the operation.Results The recovery rate of liver abscess treated by puncture was 100％,no complication occurred.Conclusions It is feasible for the liver abscess patients to perform puncture under ultrasonic guidance,and meticulous nursing is a pivotal measure to improve cure rate.

To observe the patients with type 2 diabetes who were injected premixed insulin analogues after short time continuous subcutaneous insulin infusion( CSII ) treatment.It was found that the patients needed premixed insulin analogue injection 2 times daily when the dosage of CSII was less than 45 U/d,and 3 times daily when the dosage was greater than 45 U/d.The relationship of dosages between premixed insulin analogue treatment ( Y ) and CSII treatment(X) was calculated by following equations:2 times daily premixed insulin analogue treatment:Y =13.093 +0.395X,3 times daily premixed insulin analogue treatment:Y =23.114+0.405X.