Objective To investigate the effect of nasal continuous positive airway pressure (NCPAP) on cardiac function in children with pneumonia complicated with heart failure.Methods Twenty-two children with pneumonia complicated with heart failure were selected in emergency room of Beijing Children′s Hospital Affiliated to Capital Medical University from Oct.2008 to Mar.2009,aged 1 month and 15 days to 2 years and 8 months,prospective clinical study.Cardiac function[including cardiac index(CI),heart rate(HR) and stroke volume index(SVI)] before and after NCPAP 0.04-0.05 kPa for 30 minutes were monitored by ultrasonic cardiac output monitoring(USCOM).Results After the application of 0.04-0.05 kPa NCPAP for 30 minutes,the heart rate decreased signi-ficantly [(173?10) beats/min vs (151?13) beats/min P0.05].Conclusions NCPAP might improve cardiac function by increasing stroke volume index and decreasing heart rate and respiratory rate in children with pneumonia complicated with heart failure.

Objective To investigate the pathogens and drug resistance of bacteria in children with pneumonia in Chongqing by using antibiotic reasonably.Methods Bacteria identification antibiotics sensitivity test were performed in samples of lower respiratory tract secretions from 780 cases by microscan automatic analysis machine.At the same time,respiratory virus,chlamydial and mycoplasmal pneumoniae were tested.Results The pathogens were found in 433 cases.Three hundred and sixty-four strains bacteria were isolated,116 cases were infected by virus and 26 cases by mycoplasmal pneumoniae.The resistant rates of staphylococcal and Klebsiella pneumoniae were high.The resistant rate of Streptococcus pneumoniae to penicillin was high.Haemophilus parainfluenzae was sensitive to cephalosporins.Conclusions In Chongqing,children′s pneumonia is mainly caused by bacteria.The sensitivity of antibiotic varies from different bacteria.Finding pathogens and monitoring drug resistance have taken great advantage to antibiotic selection and have prevented rapidly growing of resistant strains.

Objective To analyze the epidemiological characteristics of public health emergencies and the situation of report and control of public health emergencies in Qijiang District of Chongqing M unicipality during 2009-2013 to provide a scientific ba‐sis for the prevention and control of public health emergencies .Methods The descriptive epidemiology method was used to analyze the directly network reported data of the public health emergencies in Qijiang District during 2009-2013 from the National Emer‐gency Public Health Emergencies Reporting Management System .Results Total 47 public health emergencies were reported in Qi‐jiang District during 2009-2013 ,including 994 cases of caused disease and 1 case of death (food poisoning) .Most of the emergen‐cies were caused by infectious diseases events ,accounting for 82 .78% (39/47) ,food poisoning and other public health emergencies (dog bites) accounted for 2 .13% (1/47) and 14 .89% (7/47)respectively .Respiratory disease events accounted for 78 .72% (37/47) of total infectious diseases events ,the majority were influenza A (H1N1) flu and epidemic parotiditis .The high‐incidence seasons were from April to May(accounting for 34 .04% )and October(40 .42% ) .The most cases happened to the school (especially infec‐tious diseases) ,accounting for 80 .85% of the total events .Conclusion The respiratory infectious disease in the prevailing season is the priority of prevention and control on public health emergencies in Qijiang District .Attentions should be highly paid to the pre‐vention and control of public health emergencies (especially in rural schools);meanwhile ,the dog management and propaganda of prevention and control knowledge should be strengthened to effectively eliminate the potential of hydrophobia .

Objective To explore the feature of clinical and laboratory and therapy in childern with idiopathic pulmonary hemosiderlsis(IPH).Methods The clinical and laboratory datas of 50 cases with IPH were studied from Jan.1996 to Jan.2006.The hemogram,the metabolism of ferrum,the cellular test of bone marrow,finding the hemosiderin cells in sputum or gastric juice or bronchovesicular juice and ma-nifestation were analyzed.Results IPH were often found in children aged 6 to 14 years old.Coungh and spitting blood and anemia were the most important clinical feature.X-ray manifestations were various.The diagnosis of IPH was based on clinical feature and finding out the he-mosiderin cells in sputum or gastric juice or bronchovesicular juice.X-ray and CT manifestations were important.At the same time,the secon-dary IPH was removed.The clinical symptom of IPH were relieved by using adrenal cortical hormone.Conclusions There is no specificity in children with IPH.X-ray,CT manifestations and finding the hemosiderin cells in sputum or gastric juice are helpful in diagnosis.Using adrenal cortical hormone will release symptom and prognosis.

Cancer is still one of the major diseases threatening human life and health. At present, how to achieve precise diagnosis and treatment of tumors is the biggest challenge in cancer treatment. Prodrugs use the tumor specificity of targeting molecules to deliver anticancer drugs to tumor sites, which can effectively improve drug bioavailability, therapeutic efficacy and safety, and are currently a hot spot in the research and development of anticancer drugs. The targeting molecules of prodrugs mainly include nucleic acid aptamers, polymers, antibodies, polypeptides, etc. Among them, polypeptides have the advantages of good biocompatibility, controllable degradation performance, high in vivo responsiveness, and simple and easy preparation methods, and are widely used. It is used to construct peptide-drug conjugates (PDC) prodrugs to achieve targeted therapy of tumors. In recent years, with the development of phage peptide library technology and peptide standard solid-phase synthesis technology, more and more targeted peptides have been discovered and effectively synthesized and modified, providing strong support for the development of PDC. This review briefly introduces the types and functions of functional peptides and linkers in PDC, and discusses the application of PDC in chemotherapy, immunotherapy and photodynamic therapy in tumor targeted diagnosis and treatment, and finally summarizes the difficulties faced by PDC drug development.

Epidemiologic Methods ; Humans ; Population Surveillance ; Public Health

Objective To assess the clinical effectiveness and safety of gatifloxacin gel to bacterial conjunctivitis. Methods Double-blind and random selection were designed for the study,with levofloxacin gel as the control medicine.Thirty-six eyes of the experimental group and 36 of the control group were eligible for evaluation.Each eye received the gel one drop a time and three times per day.The gels were applied to the conjunctiva sac for 7 d. Results The clinic effectiveness of experimental group and control group were 88.89% and 91.67%,which indicated no significant difference.Microbial eradication rates were 90.48% and 93.75%,no significant difference either.Safety composite scores were similar between groups. Conclusion Gatifloxacin ophthalmic gel is safe and effective for treatment of bacterial conjunctivitis,and contains certain clinical value.

It is generally accepted that locomotion in mammals, including humans, is based on the activity of neuronal circuits within the spinal cord (the central pattern generator, CPG). Recent studies indicate a plastic behavior of the spinal neuronal circuits following a spinal cord injuries (SCI). Studies have shown that body weight support treadmill training (BWSTT) is effective in restoring locomotor function in cats with a complete spinal lesion. It has become possible to regain some locomotor activity in patients with spinal cord injury through an intense training on BWSTT, as in cat. So, it is a staired problem how to take advantage of the plasticity of spinal locomotor pattern generator and design the gait training program for SCI patients.

Objective To investigate the expression of nerve growth factor(NGF) and slouble Fas(sFas) in children with viral myocarditis(VM),and the relationship with immunity,with the aim to provide evidence and basis for the diagnosis and treatment of VM.Methods The serum levels of NGF and sFas were detected by two-site enzyme-linked immunosorbent assy(ELISA) in 43 children with VM,and 20 normal heathy children as controls.Results The serum levels of both NGF and sFas in children with the acute stage(course in less than month and 1-2 months)and the procrastinate and chronic stages of VM were significantly higher than those of healthy children(P0.05).Conclusion The increased serum expression levels of NGF and sFas are related to the process of viral myocarditis,which confirms the relationship between the onset of VM and immune factors.

Animals ; Heme Oxygenase-1 ; biosynthesis ; Kidney ; drug effects ; metabolism ; Male ; Mercuric Chloride ; toxicity ; Oxidative Stress ; drug effects ; Random Allocation ; Rats ; Rats, Wistar