Objective: To observe the effect of different kinds of fat emulsion on blood lipid and arterial blood gas analysis in critically ill preterm infants. Methods: 30 cases of preterm neonates were randomly divided into 3 groups, separately receivingno fat emulsion (control group), 20% Intralipid ( LCT, 2.0g/kg?d -1 ) or 20% Lipofundin (MCT/LCT, 2.0g/kg?d -1 ) for five days. Blood lipid determination and arterial blood gas analysis were made before and after the observation period. Results: No significant changes in blood lipid and arterial blood gas analysis were found before and after the observationin every group or between groups. Conclusion: The use of different kinds of fat emulsion at the dose of 2.0 g/(kg?d) does not affect the blood lipid and arterial blood gas in critically ill preterm infants.

Objective To study the associated factors of hospitalization delay in stroke patients. Methods Verified questionnaires were used to investigate all of the 179 stroke patients. The patients were divided into two groups according to prehospital time within or after 6 h. The associated factors of hospitalization delay were analyzed. Results The average prehospital time among 179 patients was (26.2±0.1) h, the median time was 7.5 h. There were significant differences in previous cardiac disease, distance between stroke onset site to hospital, convulsion or disorders of consciousness onset, first visit in emergency room directly or not, arriving at hospital by ambulance or not, time on ambulance between stroke onset site to hospital, time on route to hospital between the two groups (P < 0.05). Logistic regression showed the following factors were related to hospitalization delay: long distance between the site where stroke onset occurred and hospital, long time in out-patient room. Conclusions The phenomena of hospitalization delay is especially eommon and there is a low treatment rate of thrombolysis therapy in iscbemie stroke. The main reason of hospitalization delay lies in ignorance of relevant risk factors, clinical symptoms of stroke and using emergence system sufficiently.

This study was aimed to carry out the research by statistics to analyze the influence of specific clinical function of Dioscorea opposita Thunb. from the viewpoint of prescription in order to summarize its rules. Formula containing D. opposita Thunb. in the classic book of the Formula Dictionary of Traditional Chinese Medicine were recorded. The prescription type of D. opposita Thunb. was taken as the mainline. Excellwas used in the chart analy-sis. The results showed that for the function of reinforcing spleen-stomach, the effect of powder was increased, but the effect of pill was reduced. For the function of reinforcing lung and generating essence, the effect of decoction was significantly increased, but the effect of pill was significantly reduced. For the function of reinforcing kidney-yin, the effect of pill was significantly increased, but the effect of decoction was reduced. For the function of strengthening the kidney and restraining yin, the effect of powder was reduced. It was concluded that preparation had a strong in-fluence on the clinical function of D. opposita Thunb., which provided references for both clinical practice and health cultivation.

This study was aimed to optimize extraction process of formula granules of Clematis chinensis Osbeck and establish its qualitative discrimination method. With oleanolic acid, hederagenin and extract rate as indexes, extraction technology conditions of formula granules of C. chinensis Osbeck were investigated by L9 (34) orthogonal test method. TLC was used in the qualitative discrimination of formula granules of C. chinensis Osbeck. The results showed that optimum extraction technology was: adding 12 times of water; soaking for 0.5 h; cooking for 1 h; and extracting for 3 times. TLC had the diagnostic characteristic for the distinct spot which illustrated the specificity. It was concluded that the extraction process was reasonable, simple and feasible with high extraction efficiency of ef-fective contents, which can be the scientific basis for production and quality control of formula granules of C. chin-ensis Osbeck.

The characteristics of knowledge exchange in medical field of China were analyzed by social network analysis with the medical data covered in CNKI Citation Database as its study object, which showed that both the inflow and outflow volumes of clinical medicine are the largest and form the core in knowledge exchange network, preclinical medicine is the theoretical base of other medical subjects and the important knowledge source in medical networks, the interchange is close between traditional Chinese medicine, surgery and other clinical subjects, oncology is rather active in interdisciplinary studies, the interchange between stomatology and psychology is rather rare with other clinical subjects in knowledge networks and stomatology and psychology are two independent subjects.Carrying out information push service for these subjects by making use of their characteristics can improve the targeted information service, step up the knowledge exchange between different medical subjects, and promote the cooperative interdis-ciplinary studies.

Silent brain infarction (SBI) is mainly diagnosed by brain imaging which is more common in the elderly population.It is considered as the early clinical stage of symptomatic cerebral infarction and cognitive impairment.Its risk factors include age,history of smoking,hypertension,diabetes,metabolic syndrome,carotid atherosclerosis,chronic kidney disease,atrial fibrillation,and obstructive sleep apnea.The related serum biological markers include high-sensitivity C reactive protein,homocysteine,cholesterol,uric acid,and soluble intercellular adhesion molecule-1.This article reviews the advances in research on the imaging characteristics,risk factors,serum biological markers and clinical significance of SBI.

This article was aimed to study on clinical application of Shanyao (Dioscorea opposita Thunb.) in each historical period, which can offer some suggestions for clinical doctors to use Shanyao correctly. A total of 668 pieces of formulae containing Shanyao were recorded from the classic format Dictionary of Traditional Chinese Medicine Formula. And then, statistic analysis was made on the emerging frequency according to its effect. The results showed that different effects of Shanyao started to be widely applied from the Song dynasty. It was most widely applied in the Ming and Qing dynasty. Nowadays, the difference between using Shanyao has been gradually decreased. During the whole historical period, clinical functions of Shanyao are mainly reinforcing the spleen and the stomach, tonifying the kidney and strengthening yin. However, clinical functions of reinforcing the kidney and restraining yin, tonifying the lung and promoting fluid are used secondly. It was concluded that the research analyzed clinical application of Shanyao in each historical period, which can offer scientific basis for clinical practice and health maintenance with the using of Shanyao.

Objective To construct replication deficient adenovirus vector AdCMV lacZ Methods Recombinant adenovirus shuttle plasmid pAdCMVlacZ was first constructed and then lacZ cDNA cloned into Hind Ⅲ and Eco R Ⅴ of adenovirus shuttle plasmid pAdCMV by conventional methods Results The restriction enzymatic map of pAdCMVlacZ accorded with theoretic analyses and pAdCMVlacZ showed blue bacterium groups under the existence of revulsant and X gal Conclusion The adenovirus shuttle plasmid pAdCMVlacZ has been constructed successfully

AIM: To test the intraocular pressures and some biological parameters of Uyghur and Han healthy college students whose eyes are emmetropia, and to conduct comparisons between the two races, two genders, and the right and left eyes whether there is a difference between the two races.
●METHODS:Cross-sectional study. The vision of college students who reach the clinic with visual chart were tested; the keratorefractive power with an automatic refractor was tested; the eyes with slit lamp and ophthalmoscope were tested. The intraocular pressures of 405 cases ( 810 eyes in total ) with an automatic non-contact tonometer were tested; The anterior chamber depths, lens thicknesses, vitreous cavity lengths and axial lengths with an A/B - type ultrasound diagnostic equipment were tested; The intraocular pressures and some biological parameters of the two races, two genders, same genders of different races, and the right and left eyes were compared.
●RESULTS: The differences between Uyghur and Han college students in intraocular pressure, anterior depth, lens thickness, vitreous cavity length and axial length were statistically significant ( P<0. 05 ). The difference between Uyghur male college students and Uyghur female college students in anterior depth, axial length, keratorefractive power were statistically significant ( P<0. 05). The difference between Han male college students and Han female college students in axial length, keratorefractive power were statistically significant ( P<0. 05). The difference between the right and left eyes was statistically insignificant ( P > 0. 05 ). The differences between Uyghur male college students and Han male college students in intraocular pressure, anterior depth, vitreous cavity length, axial length and lens thickness were statistically significant (P<0. 05). The differences between Uyghur female college students and Han female college students in intraocular pressure, anterior depth and axial length were statistically significant (P<0. 05).
● CONCLUSION: Compared with Uyghur college students, Han college students are higher in intraocular pressure, deeper in anterior depth, longer in vitreous cavity length and axial length, and thinner in lens thickness. Compared with female college students of same race, the male college students are longer in axial length and smaller in keratorefractive power. Moreover, Uyghur male college students are deeper than Uyghur female college students in anterior depth. Compared with Uyghur male college students, Han male college students are higher in intraocular pressure, deeper in anterior depth, longer in vitreous cavity length and axial length, and thinner in lens thickness. Compared with Uyghur female college students, Han female college students are higher in intraocular pressure, deeper in anterior depth, and longer in axial length. There is no difference between the right and left eyes.

Keratoconus is a progressive, non - inflammatory corneal thinning disorder that produces a unique spectrum of change in the surface curvature of the cornea. The suspected factors associated with the cause of keratoconus include genetic mechanisms, familial associations, allergy, atopy and so on, but environmental factors, such as abnormal rubbing, contact lens wearing and ultraviolet radiation may be easily ignored. Although it is commonly thought that keratoconus is a result of various pathological progress mediated by multiple factors, those chronic trauma could play important roles in the pathological progress. The classic definition of keratoconus is still referred as a non - inflammation disorder with malnutrition of keratectasia, more and more clinical evidences and experimental results that may refute this concept. It may be due to the long-term persistent chronic trauma resulted from eye rubbing, contact lens or ultraviolet radiation. Under this conditions, the increased release of inflammatory mediators and matrix metalloproteinases may accelerate keratocyte apoposis and enzyme metabolism disorders, with the result of matrix cell lost, tensile strength decreased and keratectasia. Here, for some papers known about the relationship between chronic cornea trauma and keratoconus were reviewed and discussed its possible causal relationship.