Objective To investigate the impact of propofol and midazolam on the time course of extubation in patients with mechanical ventilation.Methods The patients were randomly divided into the propofol group(n=37)and the midazolam group(n=52),which were further divided into three sedation stratums.The administration of two drugs were stoped immediately while weaning from the ventilator.The awakening time and extubation time of the two groups were recorded and compared with each other.Results Both awakening time and extubation time of the propofol groups were shorter than those of the midazolam group(P

Adult ; Aged ; Blood Cell Count ; Caffeic Acids ; therapeutic use ; Female ; Humans ; Leukemia, Promyelocytic, Acute ; drug therapy ; Male ; Middle Aged ; Tablets ; Treatment Outcome ; Young Adult

Enteral Nutrition ; Humans ; Pancreatitis ; therapy ; Parenteral Nutrition

AIM: The impaired function of vascular endothelial cells occurs popularly in hypertensive patients. Hepatocyte growth factor (HGF) plays a crucial role on impaired function, and is related to prevalence, severity and target organ damages of hypertension. This study explored the relationship between HGF gene C57488A polymorphism and essential hypertension (EH). METHODS: ①Between June and December in 2006, totally 107 EH patients with an average age of (61?9) years, in them 47 cases with family history of hypertension, were recruited in this study. Informed consents were obtained from the patients who were all the Han residents of Hefei area, and the experiment was approved by the hospital ethical committee. The hypertension criteria formulated by Chinese Medical Association included the systolic pressure ≥140 mm Hg or diastolic pressure ≥ 90 mm Hg (1 mm Hg=0.133 kPa), or having received drug therapy for hypertension over one year. The patients were administrated with hypotensive drugs with one month. Meanwhile 110 normotensives without family history of hypertension and drug therapy were served as controls, with an average age of (60?8) years. Inclusion criteria: systolic pressure 0.05).②The distributions of HGF gene C57488A polymorphism were in agreement with Hardy-Weinberg equilibrium, indicating population representativeness. The frequencies of three genotypes CC, CA, AA were 0.809, 0.170, 0.021 and C, A alleles were 0.894, 0.106 in the EH group with family history respectively. Correspondingly, the frequencies were 0.733, 0.233, 0.033 and 0.850, 0.150 respectively in the EH patients without family history. Meanwhile, the frequencies were 0.527, 0.355, 0.060 and 0.705, 0.295 respectively in the controls.③The frequencies of genotype CC and allele C were both significant higher in EH with or without family history compared with the controls (P 0.05). CONCLUSION: HGF gene C57488A polymorphism is possibly associated with EH, and genotype CC and allele C may be the factors of genetic predisposition of EH in Han population of Hefei area.

Food Contamination ; Humans ; Infant ; Triazines ; toxicity ; Urinary Calculi ; diagnosis ; etiology ; therapy

Actins ; genetics ; Adolescent ; Cardiomyopathy, Dilated ; genetics ; Child ; Child, Preschool ; Desmin ; genetics ; Female ; Humans ; Infant ; Male ; Mutation

Objective To investigate the relationship between the insulin sensitivity and the thyroid hormone levels in the pa‐tients with type 2 diabetes mellitus(T2DM ) to provide reference for the clinical diagnosis and treatment .Methods 86 patients with T2DM were selected as the observation group and contemporaneous 72 healthy persons were selected as the control group .All pa‐tients were detected the fasting plasma glucose (FPG) ,oral glucose tolerance test postprandial 2 h blood glucose (2 h PG) and thy‐roid hormons including free tetraiodothyronine (FT4) ,free triiodothyronine (FT3) and thyroid stimulating hormone (TSH) .The insulin sensitivity index (ISI) was calculated .The relationship between the insulin sensitivity with thyroid hormone levels was ana‐lyzed .Results FT3 ,FT4 ,FT3 /FT4 ,HOMA‐IR and ISI in the observation group were (4 .82 ± 1 .13) pmol /L ,(13 .12 ± 4 .36) pmol /L 0 .39 ± 0 .08 ,2 .94 ± 0 .37 and -5 .18 ± 0 .82 respectively ,which showing statistically significant differences compared with those in the control group(P<0 .05) ,the TSH level in the observation group was (2 .51 ± 1 .03) mU /L ,the difference between the two groups was not statistically significant (P> 0 .05);HOMA‐IR and FT3 had a negative correlation (r= -0 .543 ,P=0 .000) ,HOMA‐IR and FT4 had a positive correlation (r=0 .611 ,P=0 .000) ,ISI was positively correlated with FT3 (r=0 .551 ,P=0 .001) and negatively correlated with FT 4 (r= -0 .599 ,P=0 .000) .Conclusion The thyroid hormone levels are closely corre‐lated with the insulin sensitivity ,the thyroid hormone levels may be the partial pathological causes of T 2DM pathogenesis .

Up to now,there are 21 ministry of education innovation teams established by 37 independent medical colleges and universities,which has become an important part of the medical education system innovation team building.From the perspective of SWOT (strengths,weaknesses,opportunities,threats) analysis,in the process of ministry of education innovation team establishment in the independent medical colleges,there are unique advantages,followed by obvious disadvantages,and there are favorable outside opportunities,accompanied with unprecedented challenges.Independent medical colleges shall keep up with the development trend,leverage the national regional development policy,give full play to the advantages,endeavor to overcome weaknesses,seize the opportunities and face the challenges actively,make the right strategic decisions,in order to better play an irreplaceable role in higher medical education system.

OBJECTIVE To reduce or avoid the risk factors of idiopathic sudden hearing loss in Qinghai. METHODS The clinical data of 143 sudden hearing loss patients was analyzed in Qinghai by the questionnaire. RESULTS The high incidence of sudden hearing loss happened at 2 to 6 hours after waking up in the morning. And most of the patients occurred at 18～50 years old(accounted 70.63%). 79.65% of the patients were mental laborers, 57.34% were drinkers, and 59.44% were very tired before illness. There were significant differences(P

Objective To develop a method for the determination to organochlorine pesticides by gas chromatography-mass spectra-mass spectra.Methods The temperature of inlet was 250 ℃,the injection volume was 1 ?l,without split injection.The temperature of EI source was 300 ℃,the ionization energy was 70 eV,solvent delay time was 3.75 min,transfer line temperature was 280 ℃.181,235,246(m/z)were selected as parent ion,and 145,165,176(m/z)were sub ion.Results In the range of 0-50 ?g/L,every component had a good linearity,r≥0.99,the limit of detection≤0.01 ?g/L.Its average rate of recovery was in the range of 86.1%-101.8%,and the relative standard deviations(RSDs) were between 4.41%-8.07%.Conclusion Gas chromatography-mass spectra-mass spectra is more precise for the qualitative and quantitative determination of trace organochlorine pesticides residues in drinking water.