Objective:To valuate the application of 64-slice spiral CT angiography in the arterial diseases of the lower extremities.Methods:Radiography data and treatment of 27 patients with arterial diseases of the lower extremities were reviewed,the scans cover renal artery to the artery of the lower extremity.We used workstation for 3D reconstruction Results:VR and MIP findings on 64-MSCT angiography were as follows:17 abdominal aortic and lower extremity arterial mural calcification,5 pseudoaneurysm aneursm,1 hemangioma racemosum,3 thromboangiitis obliterans,1 thrombopoiesis at anastomotic stoma.Conclusion:64-MSCT angiography has high clinical potential to be used in the diagnosis of lower extremity vascular lesions,which can help screen and define the type,size of the vascular diseases,and make programme.

Syndrome attribute determined by signs and symptoms of an animal model through intervening in the clini-cal and animal syndrome differentiation standards is not standardized, objective or rigorous. The signs and symptoms of people are difficult to be expressed fully and accurately in the animal body correspondingly. The signs and symptoms of animals are mostly without any syndrome information. There are no difference of signs and symptoms among differ-ent modeling methods. Hence, it is difficult to determine the syndrome-attribution of an animal model based on signs and symptoms. There are two problems in drug reduction to determine syndrome-attribution of animal models. Firstly, for drug reduction, only one group is used in the animal subject. There are no other two groups or multi-groups of drugs compared with each other to confirm the syndrome-attribution of animal models. Lots of research results indicat-ed that multiple drugs with different functions can change the state and the objective index of the same animal subject. Secondly, employing the control principle, adjusting and improving the best drug for the animal subject were used to determine the syndrome-attribute. However, these studies cannot be operated, because the preliminary studies, such as the essence of syndrome, have not provided generally recognized effect indexes and index groups.

Studies showed that animal model of the so-called simple syndrome currently have corresponding modern medical disease without exception. Even such animal model is called simple syndrome model, its properties is a cer-tain modern medicine disease. There is no specific corresponding relationship between the syndrome-attribution and the syndrome. The signs and symptoms differentiation and abnormal physical and chemical detection indices after pathogen-modeling of traditional Chinese medicine (TCM) cannot be determined since there are no specific corre-sponding relationships. The study on disease-syndrome combination model contains both modern medical modeling method and TCM modeling method. This type of modeling method has its own existing shortcomings. Meanwhile, two modeling methods used in the model establishment have uncertain relationship. The disease-syndrome combination model is usually not established in the comparison among different syndromes of one disease. Therefore, it has no ex-clusive attribute. There are many problems existed in the TCM modeling method, disease-syndrome combination modeling method, and syndrome-attribute evaluation methods. The basic reasons are the wide difference between symptoms and signs for diagnosis in modern medicine disease. There are a few symptoms and signs for diagnosis in modern medicine. But there are much more symptoms and signs for syndrome differentiation of the same disease. Many symptoms for syndrome differentiation are unknown for its source of origin existed in a virtual state. It caused that many virtual syndromes abstracted by virtual symptoms, and was reflected by the relevant standards. It leads to devastating consequences for the development of animal modeling method.

This study was aimed to reveal the effector mechanisms of Chinese medicine aconite, ginseng, astragalus and dried ginger on the intervention of adriamycin (ADR) cardiotoxicity model rats. The analysis was made on the interactive relationship between aconite and ginseng, astragalus as well as dried ginger. A total of 72 rats were randomly divided into nine groups. There were eight rats in each group. Except the normal group, rats in each group were intraperitoneally injected with 2.5 mg·kg-1 of ADR according to their body weights. The injection was given once a week and continued for four weeks. The total dosage was 10 mg·kg-1. In the aconite, dried ginger group, the intragastric administration dosage of herbal decoction was 1.75 g·kg-1. The decoction dosage in the gin-seng, astragalus group was 0.875 g·kg-1. The decoction dosage in the Shenfu, Qifu group was 2.625 g·kg-1. The decoction dosage in the Jiangfu group was 3.5 g·kg-1. The intragastric administration was given once a day and continued for four weeks. Indexes such as superoxide dismutase (SOD), cardiac troponins (cTn), cytochrome C (CytC), myocardial mitochondria of Bax, Bcl 2, caspase-3, caspase-9 were detected. The colligation score was calculated associating with the close index. One-way ANOVA was given on different indexes and colligation indi-cators among different drug groups and the factorial design variance analysis was given to reveal the drug interac-tions. The results showed that compared with the normal group there were statistical significances among different indexes in the model group (P < 0.05). Aconite, ginseng, astragalus, dried ginger had varying degrees of impact on different indicators. There were statistical significances on the interaction between aconite and ginseng, astra-galus, dried ginger (except Bax). It was concluded that herbal medicine aconite, ginseng, astragalus, dried ginger had certain protective effect to the heart of ADR model rats. The combination of aconite and ginseng, astragalus, dried ginger can enhance the effect compared with a single herb.

"Four properties" of Chinese herb is the core content of drug property theory.Modern research on function and substantial property of "four property" has poor progress because there has di erent cognitions,ideas and methods.In this paper,main problems of "four property" are expounded through seven aspects,meanwhile,optional ideas and methods are proposed.

According to seven features of compatibility in preface of fragment of Bencaojing Jizhu(Annotation of Materia Medica),Qianjin Yaofang(Valuable Prescriptions for emergencies) and Zhenglei Bencao(Classi ed Materia Medica),the di erences among these three books and the transformation of seven features of compatibility are investigated.The results show that the number of traditional Chinese drugs which are related to seven features of compatibility in these three books is not the same,but the xed number is 197.Before the Song Dynasty,141 traditional Chinese drugs,relating to restriction,mutual inhibition,subjugation and assistance,were not added in Bencaojing Jizhu,while 55 were added.By making use of Jiayou Bencao(Materia Medica of Jia You Reign),Zhenglei Bencao added 34 traditional Chinese drugs which are related to restriction,mutual inhibition,subjugation and assistance,in fact 35 traditional Chinese drugs were added.Approximately 10 herbological books,such as Yao Dui and Tang Bencao(Newly-Revised Materia Medica),took part in the spread of seven features of compatibility.The quantity,name,classi cation and content of restriction,mutual inhibition,subjugation and assistance between Qianjin Yaofang and Zhenglei Bencao are similar,the fragment of Bencaojing Jizhu has great di erence between Qianjin Yaofang and Zhenglei Bencao.The classi cation of seven features of compatibility of traditional Chinese drugs in those three books obey their own systems,among which the fragment of Bencaojing Jizhu adopts the three rank classi cation methods,the others incline to be rationalized and detailed.This research is valuable for compiling the early herbology and discussing the compatibility theory of traditional Chinese drugs.

Dome-shaped macula (DSM) of high myopia has been described as an inward convexity or bulge of the macular within the concavity of the posterior staphyloma in highly myopic eyes,with the bulge height over than 50 μm,which can be observed by optical coherence tomography.There are three patterns of DSM,including the typical round dome,the horizontally oriented oval-shaped dome and the vertically oriented oval-shaped dome.The pathogenesis of DSM development remains unclear,several hypotheses have been suggested,such as localized choroidal thickening in the macular area,relatively localized thickness variation of the sclera under the macula,resistance to deformation of sclera staphyloma,ocular hypotony and tangential vitreoretinal traction.Vision-threatening macular complications of DSM including serous retinal detachment,choroidal neovascularization,foveoschisis and retinal pigment epithelial atrophy.Clinically,asymptomatic patients with DSM mainly take regular follow-up observation.Appears serous retinal detachment and significant visual impairment,treatment with half-dose photodynamic therapy,supplementary of laser photocoagulation or oral spironolactone may have a beneficial effect.However,more large clinical studies are required to confirm the exact efficacy of these treatments.

Objective To investigate the association between serum uric acid (SUA)levels and outcome in acute ischemic stroke.Methods A total of 388 acute ischemic stroke patients were included in the prospective case study.Data on demographic characteristics, risk factors for life style, history of disease, the admission SUA and outcome at discharge were collected for all participants.Results Mean serum uric acid levels were (284.5±83.6) μmol/L in the normal uric acid? group, and(455.3±78.1)μmol/L in the high uric acid group(P＜0.01).There were significant differences in National Institutes of Health Stroke Scale (NIHSS) score at two weeks between the high UA group and the normal UA group [(11.0±6.0) vs.(11.0±5.3),P=0.048], and also in early neurological improvement (P=0.048).A significant difference was found in serum uric acid level between patients with good versus poor neurological function outcome (P =0.045).Conclusions There is the association between admission serum uric acid levels and outcome in acute ischemic stroke.Elevated serum uric acid level predicts a lower chance of a poor outcome in acute ischemic stroke.

Interstitial cell of Cajal (ICC) is a kind of special interstitial cell in the gastrointestinal tract,which has close connection with the smooth muscle cells and neuron cells.It is involved in gastrointestinal motility and nerve signal transduction and is considered as the pacemaker cell of slow wave of gastrointestinal tract.ICC which exists in the non-gastrointestinal organs such as biliary tract,urethra,bladder and so on is named interstitial Cajal-like cell (ICLC).This article will review the progress in the research of ICLC in the biliary system in terms of their morphology,identification,classification,function,distribution and related biliary diseases.

As the public sanitation product of the government for the society,most of the public hospitals have the privilege of the free taxations and the finance subsidies.In theory,the hospitals have the duty to offer all the patients the timely and rational cure,especially the dying patients.In reality,some hospitals often appear some kinds of nonfeasance unfortunately when they face the dying patients because of the public policy and the private rule "ready money cure".The direct aftereffect is that the patient will get worse or even die.Consequently,it's necessary to confirm the characters and the components of the nonfeasance theoretically.Thus it's easy to distinguish the hospital duty and the patient right and also the legal relationship between them on further degree,and the liabilities in accordance.