Objective To study clinical characteristics of the thalamic hemorrhage,probe into the correlation factor of judged prognosis in early days and case-fatality rate.Methods To 2003—2005 96 thalamic hemorrhage sufferer's clin- ical data were analysed.Results The advanced age and high blood pressure is main cause of disease of the thalamic hemorrhage.Conclusion To observe the thalamic hemorrhage sufferer's vital signs have the certain reference value to judged prognosis,case-fatality rate and serious complications were related to bloods closely in early days,whether break into the brain room,hypothalamus and the brain stem whether implicate.

Objective:To evaluate and analyze the application value of Acute Physiology and Chronic Health EvaluationⅢ(A- PACHEⅢ)in evaluation of the severity and prognosis of patients in SCIU.Methods:By collecting and sorting out the data of 341 cases of surgical serious patients,the severity and prognosis of patients were evaluated by APACHEⅢ.Results:Making comparison among the different types of diseases,the scores and mortality of cerebral hemorrhage and multiple hurt were high- er than those of the diseases(P

Objective: To study the marriage quality of different occupational groups. Methods: 200 married teachers from two universities and 144 married employees in hospitality industry in Hainan Province were applied Olson 's Questionnaire on Marriage Quality. Results: First, the total score of the teachers was higher than that of the employees (35. 1?6. 7/33. 5 ?6. 6, t =5. 59, P =0. 00) . Marriage satisfaction, character compatibility, communications between husbands and wives, while the arrangements of their incomes and leisure activities were also higher in teachers (t = 2. 20 -3. 37, P

Objective:To investigate the value of YL-1 puncture hematoma evacuation for hypertensive intracerebral hematoma.Methods:138 patients with hypertensive intracerecbral hematoma treated by YL-1 puncture hematoma evacuative were studied retrospectively,and the relationship between the age,the time of operation,GCS and volume of hemorrhage with mortality were with logistic regression method analysis.Results:①There were no significant relation in all the ages;②the shorter the hemorrhage,the higher the mortality;③the lower GCS was,the higher the mortality was;④the bigger the hemorrhage volume,the higher the mortality.Conclusion:The present study indicates that age is not an factor to limit minimally invasive operation(YL-1 puncture hematoma evacuation).The effect of surgery depended on the time of hemorrhage,GCS and volume of hemorrhage.

Objective To understand the clinical medicine graduates competency status of Kunming Medical University in the past 5 years and provide important reference for cultivating students in medical university. Methods The questionnaire results in the relevant departments responsible person of Yunnan provincial municipal and district 26 hospitals were system analyzed by fuzzy comprehensive evaluation method. Results In the past 5 years, the graduates occupation competence of clinical medicine in Kunming Medical University is good. Among them, the graduates’core competency gets the lowest score, but the graduates’post competency gets the highest score. Conclusion The graduates’core competency should be strengthened in training of doctor-patient communication skills and quality evaluation of clinical practice for medical students.

Objective:To lay foundation for the functional studies of programmed cell death 5 ( PDCD5 ) and develop new technical pathway for bioinformatics analysis of human functional genes. Methods:Using PDCD5 as the target molecule, intensive bioinformatics analysis of the nucleic acid and protein sequences were conducted. Data mining and comprehensive analysis by sequence against database similarity searching, ortholog structure comparison, expression profile analysis and gene “neighbor” listing were performed. Results: Two human putative pseudogenes on chromosomes 12 and 5, and one mouse putative pseudogene on chromosome 1 were identified. The methanobacterium thermoautotrophicum ortholog was classified as the same fold as ubiquitin and ribosomal protein S13. The C. elegans ortholog, ubiquitin and IAP (inhibitor of apoptosis proteins) belonged to the same expression profile cluster. This cluster was related to biosynthesis and protein synthesis. PDCD5 orthologs in various genomes were adjacent to various ribosomal proteins on the chromosome. Conclusion: The human genome contains at least two processed pseudogenes of PDCD5 . Besides the relationship with cell apoptosis, PDCD5 is predicted to have functional relationship with ubiquitin and participate in the translation regulation.

Objective To analyze the epidemic characteristics of natural foci of plague in Qinghai province in the past twenty years and to provide references for prevention and control of the disease. Methods Excel software was used to analyze the database of human plague cases and the surveillance and survey data of natural foci of plague in Qinghai province from 1999 to 2009. Results Animal plague occurred in Qaidam Basin, Qinghai Plateau and central and southern Plateau year after year, which became key areas of animal plague in Qinghai province. There were many human plague cases every year except 1999, 2000, 2002, 2007, 2008 from 1990 to 2009. Cumulative incidence of human plague was 27 cases, with incidence of 73 cases, 29 cases of death, and death rate 39.73%. Epidemic areas mainly distributed in the 4 states of Yushu, Hainan, Hercynian, Haibei.Prevalent season was from May to October. The most prevalent was pneumonic type among clinical types [60.27%(44/73)]. Conclusions Animal plague has occurred actively in key areas of Qinghai province in recent years,and an outbreak of human plague in some areas is found. Monitoring and early warning should be strengthened in the key areas, and comprehensive prevention and control measures should be implemented to reduce the incidence and prevalence of the plague.

Objective:To evaluate the analgesic effect of botulinum toxin type A (BTX-A) in osteoarthritis model and the changes of Nav1.8 protein expression in spinal ganglia changes.Method:Animal model of knee osteoarthritis (KOA) was established by intra-articular injection of 4％ papain solution 0.3ml into SD rat right knee.After the formation of arthritis,they were randomly divided into two groups at the 2nd day:BTX-A group (n=10):intra-articular injection of 5μl BTX-A 0.1IU;WFI group (n=10):intra-articular injection of 5μl water.No papain or BXT-A was given to the sham group (n=10).At the 1st,3rd,5th day after injection,we tested the pain behavior,thermal pain threshold,and sodium channel 1.8 (Nav1.8) protein expression in spinal ganglion by using immunohistochemistry.Result:Analysis of spontaneous pain behavior showed abnormal gait caused by rat osteoarthritis.Comparing with the WFI group,abnormal gait caused by osteoarthritis improved significantly in BTX-A group.At day 5 it improved more significantly than day 1 and day 3.Thermal pain threshold of BTX-A group increased more than that of WFI group (P＜0.05) at any time point.Abnormal high Nav1.8 protein in model rats decreased in spinal ganglia for BTX-A group.Conclusion:The intra-articular injection of BTX-A may play the analgesic effect in the model of KOA by down-regulating of the expression of Nav1.8 protein in spinal ganglia and reduction in the central sensitization to pain stimulation.

Objective To investigate the correlation and risk factors between vaginal intraepithelial neoplasia (VAIN) and cervical intraepithelial neoplasia (CIN).Methods A total of 121 cases of VAIN patients was retrospectively analyzed with examination results such as clinical manifestations,liquid based cytology (TCT),human papilloma virus infection,virus infection type,and clinical data of treatment and follow up.Results VAIN Ⅰ,VAIN],and VAIN Ⅲ] were accounted for 33.9％ (41/121),38.0％ (46/121),and 24.4％ (34/121) ; for 40 or less years old patients,VAIN Ⅲ was accounted for 10.7％ (3/28) ; for more than 40 years old patients,VAIN Ⅲ was accounted for 33.3％ (31 /93).Among 121 VAIN patients,77.7％ (94/121) patients had CIN history,15.7％ of which (19/121) had a history of cervical cancer; 27.3％ (33/121) with hysterectomy history,of which 75.8％ (25/33) was due to cervical intraepithelial neoplasia and cervical cancer resection of the uterus.Papilloma viral load in patients with VAIN Ⅰ was detected with a (HPV-HC2) positive rate of 87.8％ (36/41),while in VAIN Ⅱ and VAIN [patients,the positive rate was 100％,the infection of high risk type of HPV ratio was 95.9％ (116/ 121).of which the mixed infection was accounted for 56.9％ (66/116).There was 94.6％ in oatients with VAIN (114/121),and liquid-based cytology test results suggest abnormality; 88.4％ (107/121) in patients with VAIN lesions occurred in upper 1/3 of vaginal.After diagnosed cervical disease,the onset time of VAIN was (3.45 ± 2.02) years,non-total-hysterectomy was (3.24 ± 1.97) years,after hysterectomy to pathological diagnosis time for VAIN was (5.01 ± 3.95) years:for the diagnosis of VAIN disease after resection of cervical original time was (3.96 ± 2.99) years,and rather than non cervical disease resection was an average of (9.94 ±5.37) years.In the course of treatment of the 12l cases of CIN patients,6 cases of patients were progressed to invasive carcinoma.Conclusions The clinical manifestation of VAIN is similar to CIN,the principle of diagnosis and treatment of CIN can also apply to VAIN,high risk HPV infection virus,cervical intraepithelial neoplasia are the risk factors for VAIN.

Many college students’ English is not good enough to meet the need of the society. Pairing general English with ESP is proposed so as to solve the problem. Taking college English teaching in schools of traditional Chinese medicine as a case, this paper analyzes the key factors such as teaching materials, language teachers, students, teaching objectives, methods and environment in the teaching process in order to prove that pairing general English with ESP is feasible.