1.Investigation on Weight Variations and Microbial Contaminations of5Tablets Broken off with Hands
Ying'Er DING ; Dongping ZHANG ; Minli MAO ;
China Pharmacy 2005;0(19):-
OBJECTIVE:To improve medication safety and efficacy.METHODS:5different tablets broken off with hands were investigated with respect to weight variations and microbial limits by reference to Chinese Pharmacopeia.RESULTS:The5kinds of tablets broken off with hands were not in conformity with Chinese Pharmacopeia with respect to weight variation and which involved different degrees of microbial contaminations.CONCLUSION:It is recommended that pharmaceutical enter?prises should add more dosage forms of standard drugs that suitable for the use of children,women,the aged and particular patients.If the separately packaged drugs must be broken off with hands,aseptic method should be applied in which the drugs were broken off by the pharmacists on the sterile air bench before being separately packed with sterilized plastic pouches(which were sterilized with anprolene),and which should be administered to the patients for taking during the same day.
2.Advances of structure and mechanisms of bromodomain-containing protein 4 and its related research in tumors.
Qianhui HUANG ; Yiyi DING ; Yuwen TAN ; Wenxin MO ; Tongxin LI ; Ying'er HUANG ; Wenbo HAO
Chinese Journal of Biotechnology 2023;39(1):132-148
The bromodomain and extraterminal domain (Bet) family are the regulators of the epigenome and also the pivotal driving factors for the expression of tumor related genes that tumor cells depend on for survival and proliferation. Bromodomain-containing protein 4 (Brd4) is a member of the Bet protein family. Generally, Brd4 identifies acetylated histones and binds to the promoter or enhancer region of target genes to initiate and maintain expression of tumor related genes. Brd4 is closely related to the regulation of multiple transcription factors and chromatin modification and is involved in DNA damage repair and maintenance of telomere function, thus maintaining the survival of tumor cells. This review summarizes the structure and function of Brd4 protein and the application of its inhibitors in tumor research.
Humans
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Transcription Factors/metabolism*
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Nuclear Proteins/metabolism*
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Histones
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Cell Cycle Proteins/metabolism*
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Neoplasms/metabolism*
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Protein Domains