BACKGROUND: Handedness is always used for judging language dominant hemisphere. Chinese character is a sort of ideographic writing which is different from phonetic writing and the language-dominant hemisphere may also be different.OBJECTIVE: To analyze the relationship of handedness with languagedominant hemisphere of patients with cerebral infarction whose native language is Chinese.DESIGN: Case observation.SETTING: Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical College.PARTICIPANTS: A total of 400 cases of patients with cerebral infarction verified by CT and MRI were admitted in Department of Neurology of affiliated Hongqi Hospital of Mu Danjiang Medical College from February 2003 to June 2004. There were 249 male cases and 151 female cases of average age of (67.45±5.67) years old, with a course of disease of 2-4 weeks.METHODS: Handedness criterion made by Department of Neurology of First Affiliated Hospital of Beijing Medical University was used to judge handedness, and western aphasia battery was applied for classification of aphasia types.MAIN OUTCOME MEASURES: Relationship of handedness with language-dominant hemisphere of patients with cerebral infarction.RESULTS: According to actual procession and analysis, all the 400 cases entered results analysis. ① There were 366 cases of right-handedness and 34 cases of non-right-handedness. ② There were 169 cases of patients with aphasia out of 237 cases of left hemisphere lesions and 9 cases of patients with aphasia out of 163 cases of right hemisphere lesions. ③ Among 366 cases of right-handedness, there were 158 cases of aphasia out of 218 cases of left hemisphere lesions and 7 cases of aphasia out of 148 cases of right hemisphere lesions. Among 34 cases of non-right-handedness, there were 11 cases of aphasia out of 19 cases of left hemisphere lesions and 2 cases of aphasia out of 15 cases of right hemisphere lesions. CONCLUSION: Among people whose native language is Chinese, most dominant hemispheres of right-handed people among patients with cerebral infarction are left cerebral hemispheres and few are right cerebral hemispheres; most dominant hemispheres of non-right-handed people are left cerebral hemisphere and few are right cerebral hemisphere.

BACKGROUND: The location of cerebral infarction determines the onset and type of aphasia, but this relationship may fail to explain some clinical findings in these patients. The exact relationship between the type of aphasia and the locations remains to be fully unclear.OBJECTIVE: To investigate the relationship between the location of cerebral infarction and the type of aphasia.DESIGN: Case-controlled study.SETTING: Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical University.PARTICIPANTS: Totally 98 patients admitted in the Department of Neurology, Hongqi Hospital Affiliated to Mudanjiang Medical University for aphasia secondly stroke between August 2003 and June 2004 were enrolled in this study, including 63 male and 35 female patients with the mean age of (68±4.56) years and disease course varying from 2-4 weeks.METHODS: Handedness evaluation was performed using the subtest of handedness in the Chinese aphasia test battery designed by the Department of Neurology, First Hospital of Beijing Medical University. Aphasia was classified on the basis of Western Aphasia Battery and evaluated for severity according to the grading criteria of Boston Diagnostic Aphasia Examination. The patients received also CT and MRI examinations.MAIN OUTCOME MEASURES: Aphasia type and lesion site in pa-tients with cerebral infarction.RESULTS: Analysis was made according to the real data, all 98 cases entered into the result analysis. All the 98 aphasic patients were right-handed,with 21 patients having Broca's aphasia, 15 Wernicke's aphasia, 2 conduction aphasia, 8 transcortical motor aphasia, 7 transcortical sensory aphasia,12 transcortical mixed aphasia, 23 complete aphasia and 10 anomic aphasia. The lesion involved the classic language function area in 56 cases, and did not affect the language functional area in 38 cases. According to the grading criteria of Boston Diagnostic Aphasia Examination, 28 patients were in grade 0, 30 in grade 1, 14 in grade 2, 16 in grade 3 and 10 in grade 4.Most of the patients in grades 0 and 1 had lesions involving the language functional area.CONCLUSION: Aphasia type does not totally conform to the classic speech center lesions, and involvement of the non-speech centers may also cause aphasia, but speech center lesions lead to more serious aphasia.

Objective To explore the expression and effect of MP0 and TGF-β1 in ulcerative colitis tissues.Methods The expressions of MPO and TGF-Bl in colonal tissue specimens were determined by immunohistochemistry(two step method)in 37 cases of ulcerative colitis,10 crohng disease and 20 normal mucosa.Results The positive rates of MPO and TGF.B1 were 10％and 20.0％in the normal mucosa,55.0％and 35.O％in crohn's disease,and 89.2％and 86.5％in ulcerative colitis.Expression of MPO and TGF-β1 in the ulcerative colitis were higIIer than that in crohn's disease and normal mucosa(P<0.05),there was correlation between MPO and TGF-β1(r=O.51,P<0.05).Conclusion MPO and FGF-β1 are involved in the pathology of UC,and detection of MPO and TGFβ1 can provide some value to evaluate the conditions of UC.

Objective To study the determinants of exercise behavior among the overweight and obese residents, so as to provide reference for policy-making and health promotion in the future. Methods The study only enrolled overweight and obese residents to conduct a questionnaire survey and physical examination including height, weight and waist circumference. The self-designed questionnaire based on Health Belief Model had acceptable validity and reliability. Structural Equation Modeling was used to analyze the determinants of exercise behavior after univariate analysis and correlation analysis. Result Totally 2 489 overweight and obese residents(1 182 male and 1 307 female)were included in this study. Their average age was 45.3±14.2 years and their median amount of exercise was 4 thousand-step equivalent with quartile of (0.5, 10.0); 22.9% of these residents never took any exercise. Males with high school and equivalent level of education and an income of 5 000 to 10 000 yuan, took more exercise than other demographic groups. Amount of exercise had a positive correlation with perceived benefits of exercise, perceived severity of disadvantage of low exercise and self-efficacy, while it had a negative correlation with subjective barriers and objective barriers. Structural Equation Modeling showed that perceived subjective barriers, objective barriers and self-efficacy were determinants of exercise behavior. Their total standardized effects on exercise behavior were-0.085 (P=0.020),-0.242 (P<0.001) and 0.184 (P<0.001) respectively.Those with higher self-efficacy and less barriers preferred to do more exercise. Indirect effect widely existed in the SEM and self-efficacy were the most important mediating variables of all the other significant determinants. Conclusion The overweight and obese residents are seriously lack of exercise, which need some targeted intervention, especially by improving their self-efficacy and reducing their objective barriers.

OBJECTIVETo explore the influence of recombinant human growth hormone (rhGH) on the apoptosis and intestinal mucosal structure in severely scalded rats.

METHODSThirty male Wistar rats were randomly divided into three groups, i.e. control, scalding and rhGH groups. The rats in scalding and rhGH groups were inflicted with 25% TBSA III degree scalding on the back and immediately followed by intraperitoneal injection of dexamethasone (80 mg/kg). The scalded rats were administered with normal saline and rhGH (1.33 IU.kg(-1).d(-1)) since 2 postburn hours (PBHs), respectively in the last two groups. The changes of the apoptosis rate, the intestinal mucosal proliferative index (PI) and epithelial ultrastructure and the intestinal mucosal pathomorphology of the distal end of ileal mucosal tissue were observed on 30 and 96 PBHs.

RESULTSThe intestinal mucosa morphology and epithelia in scalding group were severely injured but were significantly ameliorated by rhGH to near those in control group. The PI in rhGH and scalding groups at 30 PBHs was evidently higher that that in control group (P < 0.05 - 0.01). But the PI exhibited no obvious difference between scalding and rhGH groups. While the PI in rhGH group at 96 PBHs was obviously higher than that in both scalding and control groups (P < 0.01). The intestinal mucosal epithelial apoptotic rate in scalding group was significantly higher than that in control group (P < 0.01), while that in rhGH group was evidently lower than that in scalding and control groups (P < 0.05 - 0.01).

CONCLUSIONrhGH could promote postburn intestinal mucosa epithelial proliferation in slow - action manner and inhibit intestinal mucosal epithelial apoptosis with rapid and obvious effects. As a result, the intestinal mucosal epithelial injury could be ameliorated by rhGH by means of its inhibiting roles and the normal morphological structure of intestinal mucosa was maintained ad hoc.

Animals ; Apoptosis ; Burns ; pathology ; Human Growth Hormone ; genetics ; pharmacology ; Intestinal Mucosa ; drug effects ; pathology ; Male ; Rats ; Rats, Wistar ; Recombinant Proteins ; pharmacology