Objective To study the efficacy of bronchoalveolar lavage and drug injection by bronchofibroscope in patients with refractory pneumonia.Methods 62 cases with refractory pneumonia were divided into therapy group(40 cases) and control group(22 cases).All patiens were treated with conventional therapy,bronchoalveolar lavage and drug injection by bronchofibroscope were treated for patients in therapy group in addition.Therapeutic effects were compared between two groups.Results The effective rates of therapy group were significantly higher than that in control group(85.0％ vs 54.5％,x2 =8.511,P=0.014).The control of temperature,amount of sputum,absorption of the lesions and hospitalization days in therapy group were better than those in control group (all P ＜0.05).Conclusion Bronchoalveolar lavage and drug injection by bronchofibroscope is effective for patients with refractory pneumonia,which can shorten the course of treatment,improve prognosis,and deserve the clinical expansion.