Amyotrophic lateral sclerosis is a chronic neurodegenerative disorder characterized by selective death of motor neurons and progressive paralysis. Many hypotheses have been proposed to explain its pathogenesis. In recent years,one of the most studied hypotheses was the inflammatory response accompanying the motor neuron death. Microglia and its interactions with motor neurons play important roles in the development and progression of the inflammatory responses and the disease itself,which results in different new and potent therapeutic strategies of great clinical value.

External fixators have been widely u sed in treatment of war trauma due to t heir small size,light weight,easy application,and convenience in transport.There are several types of military external fixato r,such as FESSA(Fixateur Externe du Service de Sant?des Arm?es),CMC(Croatian Medical Corps),Synthes and Hoffman-Ⅱ.All of these have been used on the battlefields of Rwandese War,Croatia Wa r and the first Persian Gulf War.Most of military external fixators are unilateral connectable-joint.For temp orary fixation,one bar is enough;by adding another parallel bar,the fixation can be use d for long-time fixing.Facing with a great demand of war trauma treatment ,we should develop new types of military external fixator with more simplicity and less size or weight. [

Amyotrophic lateral sclerosis is a chronic neurodegenerative disorder characterized by selective death of motor neurons and progressive paralysis. Many hypotheses have been proposed to explain its pathogenesis. In recent years, one of the most studied hypotheses was the inflammatory response accompanying the motor neuron death. Microglia and its interactions with motor neurons play important roles in the development and progression of the inflammatory responses and the disease itself, which results in different new and potent therapeutic strategies of great clinical values.

Acupuncture Therapy ; instrumentation ; Adult ; Female ; Humans ; Male ; Middle Aged ; Muscle Strength ; Piriformis Muscle Syndrome ; physiopathology ; therapy

Background: Induction of anaesthesia with propofol is often associated with a significant decrease in arterial pressure, especially in the older population. The aim of this study is to determine the efficacy of phenylephrine in two different doses i.e. 100mcg and 200mcg, given during induction to counteract the anticipated hypotensive effect of propofol in older patients aged over 55 years. Methods: Seventy-two ASA physical status I – II patients aged 55 years or older were randomly allocated to group 1 (received propofol mixed with normal saline), group 2 (propofol mixed with 100mcg of phenylephrine) or group 3 (propofol mixed with 200mcg of pheynylphrine). Anaesthesia was induced with fentanyl 1.5mcg/kg and propofol 2mg/kg (mixed with the study drug). Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and heart rate (HR) were recorded at 1 minute intervals for up to 5 minutes after induction. Results: SBP, MAP and DBP decreased significantly after induction in the control group and group 2 (phenylephrine 100mcg). In contrast, SBP was maintained to near baseline for the first two minutes after induction using phenylephrine 200mcg in group 3, and similar trends were seen with MAP and DBP at a lesser magnitude. Conclusion: Phenylephrine 200mcg is more effective than 100mcg in attenuating propofol induced hypotension, especially during the first two minutes after induction, in patients aged 55 years and above.
Phenylephrine ; Propofol

The epithelial-mesenchymal transition (EMT) is characterized by absence of epithelial phenotype and acquiring of mesenchymal properties. EMT participates not only in normal embryonic development, wound healing and tissue reconstruction, but also in various pathologic processes, including fibrosis and carcinogenesis. EMT can facilitate the invasion and metastasis of cancer cells to distant tissues, and confer the metastatic cancer cells self-renewal ability of stem cells, contributing to macroscopical metastasis formation and multiple resistance to treatment. Recent studies have revealed that several transcription factors, signaling pathways, microRNAs and microenvironment components are involved in this process. Here we summarize the recent progress on the roles of EMT and cancer stem cells in tumor metastasis, hoping to provide new insights in target therapy of tumor metastasis and recurrence.

Objective To study the efficacy and indications of percutaneous radiofrequency ablation (PRFA) for small primary liver cancer(SPLC). Methods The clinical data of 16 patients with SPLC treated by PRFA were analysed retrospectively. Results The diameter of tumor in all 16 patients were ≤3cm. After PEFA, AFP from postive returned to negative in 93.3% of patients; and BUS and CT showed the tumors shrinking with capsule formation. The 0.5,1,2-year survival rate were 93.8%,100%,100% respectively. Conclusions PRFA for SPLC has advantages such as minitrauma, safe and effective, especiolly suitable to the patients with contrainsications of operation, or the tumor locating to the deep position of liver, or around inferior vena cava, hepatic veins or hepatic porta etc.

Objective To study the effect of the evidence-based nursing in the treatment of acute myocardial infarction by the early thrombolytic therapy with urokinase.Method 138 patients with acute myocardial infarction were randomly divided into the observation group and control group in equal number: the former received the evidence-based nursing and the latter conventional nursing care.The two groups were compared in terms of recanalization rate,fatality and incidence of angina.Result The recanalization rate,fatality and incidence of angina in the observation group were all significantly lower than those in the control group(all P<0.05).Conclusion The evidence-based nursing used to nurse the acute myocardial infarction patient to be treated by is cared by early thrombolytic therapy with urokinase may prevent such complications as angina and reduce recanalization rate and fatality.