1.The phenotypes of a hypercholesterolemia family with low density lipoprotein receptor exon 13 A606T mutation
Xinyao CHENG ; Xiaohuan CHENG ; Yin ZHANG ; Fang ZHENG ; Aili WANG
Chinese Journal of Internal Medicine 2012;51(9):680-682
ObjectiveTo investigate the clinical phenotypes of familial hypercholesterolemia (FH) caused by exon 13 A606T mutation in low deusity lipoprotein receptor.MethodsClinical data of the suffered family were collected and analyzed,as well as measurement of perivascular intima-medial thickness and follow-mediated-dilation function by ultrasonography.ResultsThere were totally 11 sufferers including 4 males and 9 females,aged 8-90 years,with 2 homozygotes and 9 heterozygotes.Among them, one homozygote showed angina pectoris and hematuria,both homozygotes had skin xanthomata.TC,TG,LDL-C and HDL-C were(7.39 ± 1.30) mmol/L,(0.93 ± 0.36) mmol/L,( 11.76 ± 1.10) mmol/L and ( 1.22 ±0.17) mmol/L,respectively.The left/right sided intima-medial thickness of the common,internal,external and bulb carotid artery were ( 1.15 ±0.45) mm/( 1.30 ±0.60) mm,(0.82 ±0.30) mm/( 1.00 -0.66)mm,(0.77 ±0.28) mm/(0.78 ±0.30) mm and ( 1.40 ±0.59) mm/( 1.46 ±0.71 ) mm respectively.The brachial artery flow mediated dilation rate was (4.85 ±4.80)%.Echocardiography revealed 2 patients with cardiac valvular disease and 3 with atrium septum aneurysm. ConclusionFH patients show a variety of phenotypes incuding extraordinary hypercholesterolemia,subcutaneous xanthomata and premature coronary heart disease.
2.Reconstruction of external nose defect with local flaps.
Fuwei CHENG ; Yin LI ; Weitian ZHANG ; Huaming ZHU ; Hongming WU ; Yujun ZHANG ; Shankai YIN
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2013;27(23):1303-1306
OBJECTIVE:
The role of different local flaps in small external nasal skin defect reconstruction was discussed.
METHOD:
Forty-two cases of the small size nasal defects (diameter < 2 cm) were repaired with local external nose flap (includes the dorsal nasal flap, nasolabial flap and bilobed flap). The clinical and follow-up data were analyzed of patients with small external nasal skin defects, who accepted different local flaps reconstruction. Dorsal nasal flap, nasolabial flaps (includes island flap, slid flap and axial flap) and bilobed flap were tailored to reconstruct different external nasal defect. Twenty-seven patients were male and fifteen patients were female, the patients' age ranged from 28 to 74 years, the median age was 61 years. Thirty-eight cases resulted from resection of skin malignant tumor and four cases were benign lesions. The diameter of defects was 1-2 cm. The defects were reconstructed by single-stage dorsal nasal flap in 7 cases. There were 30 cases of caudolateral nasal defects were reconstructed by nasolabial flap, single-stage island nasolabial flap in 7 cases, axial flap in 18 cases and slid flap in 5 cases. Superior lateral defects were reconstructed by single-stage bilobed flap in 5 cases.
RESULT:
All defects were repaired successfully. All tissue flaps survived and had not necrosis. There was no tumor recurrence during 3 months to 2 years follow-up.
CONCLUSION
The dorsal nasal flap, nasolabial flap and bilobed flap can be used safely and effectively to repair the small external nasal defect and have satisfactory curative effect.
Adult
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Aged
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Dermatologic Surgical Procedures
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methods
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Face
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pathology
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surgery
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Female
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Humans
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Male
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Middle Aged
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Nose
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pathology
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surgery
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Reconstructive Surgical Procedures
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methods
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Skin
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pathology
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Surgical Flaps
4.Autologous iliac crest graft combined with autologous bone marrow stem cell transplantation for bone nonunion after fracture surgery
Yin CHENG ; Xiaobo LU ; Yun ZHANG ; Lvfang YING
Chinese Journal of Tissue Engineering Research 2016;20(51):7605-7610
BACKGROUND:Bone nonunion is a common complication in the orthopedic treatment, and its morbidity reached 5%-10%, which results in the long-term functional disturbance of the limbs, and even disability. Autogenous iliac crest graft has been commonly used to treat bone nonunion, but some limitations stil exist.
OBJECTIVE:To investigate the treatment outcomes of autogenous iliac crest graft combined with autologous bone marrow stem cel transplantation for bone nonunion after fracture surgery.
METHODS:Clinical and fol ow-up data from 69 patients with bone nonunion were analyzed retrospectively. Al patients were al otted to combination (n=37) and iliac (n=32) groups, fol owed by treated with autologous iliac crest graft combined with autologous bone marrow stem cel transplantation or autologous crest graft, respectively. Afterwards, the hospitalization time, fracture healing time, bone mineral density and Fereadez-Esteve cal us scores were detected and compared between groups.
RESULTS AND CONCLUSION:The hospitalization time did not differ significantly between groups (P>0.05). The fracture healing time in the combination group was significantly shortened compared with the iliac group (P<0.05). The bone mineral density and Fereadez-Esteve callus scores in the combination group were significantly higher than those in the iliac group at 3 and 6 months after surgery (P<0.05). The excellent and good rate of the affected limb function in the combination group was significantly higher than that in the iliac group (P<0.05). These results suggest that autogenous iliac crest graft combined with autologous bone marrow stem cell transplantation for bone nonunion can accelerate fracture healing, promote porosis and improve the functional recovery of affected limbs.
5.Study on the evaluation index system of the quality of health education among the elderly in the community
Xuefen LAN ; Zhiqin YIN ; Guiling GENG ; Liming ZHANG ; Xiaolin CHENG
Chinese Journal of Practical Nursing 2014;30(30):1-5
Objective To establish a scientific and feasible evaluation index system of the quality of health education among the elderly in the community.Methods Based on the results of literature review,theory analysis,cross-sectional study and interviews,a draft evaluation index system was formulated.Then Delphi method was conducted on 28 specialists around the country,the weight of each index was determined by hierarchy analysis.Results After three rounds of Delphi procedure,the response rates of the three round consultation were all above 85%,and the authority coefficient and coordination coefficients was 0.858,0.210,respectively.An evaluation index system which covered three first-level items,7 second-level items and 35 third-level items was formulated.Conclusions Based on survey of the elderly and interviews of health education staffs in the community,and using the method of Delphi to collect experts' suggestion,a strong maneuverability and high reliability quality evaluation index system was formulated,which provided guidance for community health education of the elderly,and promoted its development towards scientization and standardization.
6.Inhibitation of proliferation of human acute myelogenous leukemia cells in vitro by celastrol
Yaping ZHAI ; Yin ZHANG ; Baogen MA ; Wei CHENG
Journal of Leukemia & Lymphoma 2011;20(2):76-78
Objective The current study was designed to investigate the inhibitive effect of celastrol on the proliferation of acute myelogenous leukemia (AML) cells. Methods The effect of celastrol on AML cells in vitro was examined by MTT assay and flow cytometry (FCM). Results After the AML primary cells were treated with different concentrations of celastrol, the results were analyzed by MTT. The growth of the cells were significantly inhibited compared with the control group (P <0.01). The results detected by FCM showed that the apoptosis was seen after treated with celastrol with different concentration for different times.The apoptotic rates were significantly higher than that in the control group with statistical significance (P< 0.01).Conclusion Celastrol could inhibit the proliferation of AML cells in vitro, which may be associated with inducing cell apoptosis.
7.Popularizing subscription of personal RSS products in subject librarians
Xiaoyan ZHANG ; Liang YIN ; Jin CHENG ; Fangwei LI
Chinese Journal of Medical Library and Information Science 2014;(9):45-47
After the problems found in academic information push service and information literacy training of sub-ject librarians in Medical Library of Chinese PLA were analyzed , the concrete contents of subscribing personal RSS products in a certain institute of Academy of Military Medical Sciences and the feedback of its users were described with suggestions put forward for deepening the academic information push service, such as establishing personal RSS account for research rooms and implanting certain RSS subscription contents into the subject service platform.
8.Study on cost-effectiveness of primary cerebral infarction patients
Yuan YANG ; Meng WANG ; Liang ZHANG ; Fuchun CHENG ; Ling YIN
Chinese Journal of Disease Control & Prevention 2009;0(02):-
Objective To study cost-effectiveness of primary cerebral infarction patients. Methods The neural function of primary cerebral infarction patients was studied by the National Institutes of Health Stroke Scale (NIHSS) with rank test and multiple regression analysis. Results After treatment in hospitals of different grades, no obvious difference was detected in the NIHSS score, but difference was found in therapy cost and therapy time; the NIHSS score and therapy time of primary cerebral infarction patients in different attack positions were obviously different, but therapy cost had no significant statistical difference. The NIHSS score of primary cerebral infarction patients with different treatments was obviously different, but therapy cost and therapy time was not. Conclusions Patients are advised to choose grade hospitals in nearby cities for treatment. Clinician are expected to choose low-cost treatment plan to relieve patients' economic burden.
9.Influential factors on the ratio of plasma aldosterone concentration to plasma renin activity in screening primary aldosteronism
Guoshu YIN ; Shaoling ZHANG ; Li YAN ; Hua CHENG
Chinese Journal of Endocrinology and Metabolism 2009;25(2):238-241
The ratio of plasma aldosterone concentration to plasma renin activity (ARR) is a practical parameter in screening for primary aldosteronism (PA).However,variations of the cutoff value of ARR in different studies have been reported due to plenty of influential factors that may affect the secretions of renin and aldosterone. Lack of standardization of assays for ARR also makes direct comparisons among different studies difficult.The associated influential factors on ARR were introduced in this review.
10.Analysis of paraquat intoxication epidemic (2002-2011) within China.
Yu YIN ; Xiang GUO ; Shou Lin ZHANG ; Cheng Ye SUN
Biomedical and Environmental Sciences 2013;26(6):509-512
Adolescent
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Adult
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Child
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Child, Preschool
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China
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epidemiology
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Disease Outbreaks
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Female
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Herbicides
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poisoning
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toxicity
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Humans
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Infant
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Infant, Newborn
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Male
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Middle Aged
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Paraquat
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poisoning
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toxicity
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Risk Factors
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Time Factors
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Young Adult