In the past, education of acupuncture/ moxibustion in Taiwan depended on the masters-disciples relation. The knowledge of acupuncture/ moxibustion was transmitted to disciples individually.
Since its establishment in 1955, The Taipei Society Acupuncture and Moxibustion improved educational pro- gram to more systematic one. In the following 20 years varieties of studies in this field were conducted, people also turned their eyes to these traditional remedies
Though acupuncture and moxibustion had begun to be accepted by people, the new medical law was en- forced in 1975, which disqualified the acupuncturists for medcial practice. As a result, many of the acupuncturists and moxibustionists left Taiwan for overseas. Unlike many other nations, Taiwan has no system for certification of acupuncturists/ moxibustionists. The traditional Chinese doctor in Taiwan, after passing the examination for Chinese Medicinal exam can practice the Chinese herbal medicine and the acupuncture/ moxibustion. It seems an inconceivable system.
It is only after 1989 that the subjects on acupuncture/ moxibustion medicine were included in the exams for the traditional Chinese doctor in Taiwan. But it still doesn't include tests of practical skills. This is more of a hindrance than a contribution to acupuncture and moxibustion in Taiwan.
Though there has been the legalization movement for acupuncturists/ moxibustionists during the past 30 years, it met opposition from both of the health bureau and the traditional Chinese doctor trade union. The license system for acupunturist is still left uncertain.
Now in Japan, the high tech device like electronic microscope, micro inductor and micro-electric are introduced in the studies of acupuncture/ moxibustion medicine. And in the field of scientific research of the acupuncture and moxibustion, Japanese seem to have more grant view than other country. The health government of Taiwan should turn their eyes to the reality and change its policies towards this effective medicine.
Now acupuncture and moxibustion medicine has become one of the international research topics. In recent years WFAS academic congresses are held every year in the different nations. Here I would like to suggest that in advanced country like Japan, a new university specializing in acupuncture/moxibustion medicine should be established and it should accept and educate foreign student from overseas with international curriculum. Only the continuous and faithful exchange of the young scholars would recover the true friendship between Taiwan and Japan.

OBJECTIVE: To develop software for individualized dosage regimen of valproic acid and carbamazepine according to population pharmacokinetics and Bayesian estimation method. METHODS: Based on the prior population pharmacokinetic (PPK) information, Microsoft Excel 2010 was employed as the input-output interface to run the PPK program, Nonlinear Mixed Effect Modeling (NONMEM), to estimate the PK parameters and design the regimen. RESULTS: The software fulfills the functions of patient information management, initial dosage design, dosage calculation by maximum a posterior Bayesian estimation (MAPB) and compliance assessment. CONCLUSION: The established software provides a powerful tool in the clinical settings to facilitate the individualized therapy for the epilepsy patients.

Objective To study the relationship between helicobacter pylori(Hp) infection and iron deficiency anemia(IDA) in children. Methods The observation group contained 26 cases and control group 22 cases.Seroferroprotein(SF) and blood routine were detected.Results There was statistically significant difference in both groups on the SF,hemoglobin,red blood cellcount,mean corpuscular volume and mean corpuscular hemoglobin concentration (P0.05). Conclusion Hp infection may be related to IDA in children.

Objective To investigate the therapeutic effect of argon-helium cryoablation combined with sorafenib on hepatitis B-related advanced hepatocellular carcinoma (HCC) and to evaluate the role of microvessel density (MVD) in prognostic evaluation. Methods A total of 102 patients with advanced HCC were randomly divided into two groups, with 50 receiving sorafenib plus cryoablation(group S&-C) and 52 receiving only cryoablation (group C). The endpoint of the treatment was tumor progression or untolerable adverse reaction. Tumor tissues were obtained before treatment. MVD was evaluated by immunohistochemical analysis using CD34 antibody. The therapeutic effects were evaluated according to RECIST criterion every 4-6 weeks. The adverse events were observed in both groups; the therapeutic effect, overall survival time (OS), and time to progression(TTP) were compared between two groups. Results In group ScV-C, complete response (CR) was achieved in 2 patients(4%), partial response (PR) in 9 (18%), and stable disease(SD) in 22(44%), with the disease control rate(DCR) being 66%; in group C. no CR, PR in 4(7. 6%), and SD in 19(36. 5%), with the DCR being 44. 2% (P<0. 05). The overall survival (OS) and the time to progression (TTP) were significantly longer in group S&-C than in group C (12. 5 months vs 8. 6 months, 9. 6 months vs 5. 3 months; P<0.01). The mean MVD in group CR&.PR (111/0.74 mm2) was significantly lower than that in group PD( 339/0. 74 mm2, P<0.01). Patients with lower MVD receiving sorafenib plus cryoablation had longer OS and TTP than those only receiving cryoablation. The OS and TTP in patients with higher MVD had no significant difference between different groups. Conclusion Sorafenib plus cryoablation is a safe and effective therapy for patients with advanced HCC; it can improve the OS and TTP of patients. Patients with higher MVD have a lower response to therapy and poor prognosis.

目的探讨矫形器训练对改善下肢功能障碍患者日常生活活动能力的作用。方法将64例下肢功能障碍患者随机分为矫形器组和对照组各32例。对照组采用自我锻炼方法,矫形器组安装矫形器,两组均同时接受正规康复训练、心理指导及康复护理。于分组前及分组治疗4周后评定患者的疗效。结果两组患者的Barthel指数评分均有一定程度的提高,但矫形器组患者的评分明显优于对照组(P<0.01)。结论下肢功能障碍患者使用矫形器4周后即能明显提高日常生活活动能力。

OBJECTIVETo study the expression difference in MicroRNA-21 (miRNA-21) levels of the plasma between the patients with coronary heart disease and the subjects without coronary artery lesions, and its clinical significance.

METHODSPlasma was obtained from the patients with coronary heart disease(trial group,56 cases) and the subjects without coronary artery lesions(control group, 10 cases), patients with coronary disease were divided into angina(AP, 39 cases) and acute myocardial infarction(AMI, 17 cases)subgroup, the contents of miRNA-21 were detected using qRT-PCR method, and the differential expression of miRNA-21 in each group was analyzed. The levels of creatine kinase isoenzyme (CK-MB), high sensitive troponin I(cTnI), B type natriuretic peptide urea (BNP), Gensini, left ventricular ejection fraction (LVEF), integral value of coronary left ventricular end diastole diameter (LV) and homocysteine (HCY) were determined and the correlation between miRNA-21 and these clinical indexes was analyzed.

RESULTSCompared with control group, there was a significant difference in expression of miRNA-21 in patients with angina and AMI (P < 0.05), and miRNA-21 expression in AMI group was much higher than that in AP group. There was statistical significance in CK, CK-MB, cTnI, Genisis integral comparison between AMI group and control group (P < 0.05). The correlation analysis showed that there was a positive correlation between expression of CK, CK-MB, cTnI and the level of circulating miRNA-21 in patients with acute myocardial infarction. And there was a negative correlation between BNP, Gensini integral, LVEF value of coronary artery, LV and circulating miRNA-21.

CONCLUSIONmiRNA-21 was significantly elevated in acute myocardial infarction subgroup than the control group. The level of miRNA-21 associates with the degree of coronary artery stenosis, and might be a potential marker for the diagnosis of acute myocardial infarction. miRNA-21 may play an important role in protecting myocardium from ischemia/reperfusion injury.

Acute Disease ; Biomarkers ; blood ; Coronary Disease ; blood ; Creatine Kinase, MB Form ; metabolism ; Humans ; MicroRNAs ; blood ; Myocardial Infarction ; blood ; Natriuretic Peptide, Brain ; metabolism ; Troponin I ; metabolism

Drug clinical trial is an important link in the chain of new drug research and development. The results of drug discovery and development directly depend on the extent of standardization of clinical trials. Therefore, improving the quality of drug clinical trials is of great importance, and drug clinical trial institutions play a crucial role in the quality management of drug clinical trials. After years of development, the overall level of drug clinical trials has advanced rapidly in China, and a large number of clinical trials of traditional Chinese medicine have also been carried out. However, there is still a big gap between our country and developed countries. Therefore, for the construction and management of Chinese drug clinical trial institutions, there is still a long way to go. This study aims to analyze the current development of drug clinical trial institutions in China and explore the existing problems from three aspects, including current situations of institutional organization and management, regional and professional distributions, and quality control. And some suggestions are put forward finally, including support of traditional Chinese medicine, introduction of drug-risk management system, and construction of information management.
China ; Clinical Trials as Topic ; standards ; Drug Evaluation ; Drug Therapy ; standards ; trends ; Drugs, Chinese Herbal ; standards ; therapeutic use ; Humans ; Quality Control ; Research

In order to verify the origin relations of Zhouhou Emergency and modern clinical medicine in emergency treatments,we choose Zhouhou Emergency as study object,and try to verify four treatments including artificial respiration,urethral catheterization,surgical infection and hemostasis. Through tracing back to the initiation and developing history of modern medical technique,it fixes its position in modern emergency treatments,and affirms the important roll of Chinese ancient books in promoting the techniques of modern emergency science.

Objective To explore and compare the effect of sevoflurane and disoprofol to inflammatory factors in patients received abdominal surgeries.Methods Patients with sevoflurane and disoprofol respectively were anaesthetized and detected IL-6,IL-8,IL-10 and TNF-α in their serum at T1 (when anesthesia induction),T2 (after anesthesia induction),T3 (30min after beginning of operations) and T4 (after operations).Results Compared with T1,the serum level of IL-6,IL-8,IL-10 and TNF-α increased significantly in all patients(all P ＜ 0.05) ; Compared with disoprofol group,the serum level of IL-6,IL-8 and TNF-α increased significantly (all P ＜ 0.05) ; Compared with sevoflurane group,the serum level of IL-10 increased significantly(all P ＜ 0.05).Conclusion Intravenous anesthesia with disoprofol in patients receiving abdominal operations is proper for maintenance of inflammatory balance.

Objective To study the changes in small intestinal motility during the process of gallbladder cholesterol stone formation.Methods Forty guinea pigs were divided into two groups of 20 each,the experiment group fed on high cholesterol diet ( cholesterol 2％ ),while the control group on normal diet.Animals were sacrificed at 8 weeks.Slow wave and tension of the isolated small intestinal muscle specimen were measured using a multi-channel physiological recorder,and its relation to gallstone formation was assessed.Results Compared with the control group,the frequency and amplitude of the slow wave significantly reduced in the experimental group (5.70 ± 1.05/min vs.17.45 ± 1.50/min and 0.23 ± 0.31 my vs.0.78 ±0.17 mv respectively,P ＜0.05).The t-value between the two groups were -27.083 and - 13.236 respectively; Frequency of contraction and muscle tension also reduced significantly (5.94 ± 1.25/min vs.15.85 ± 1.76/min and 0.78 ±0.002 g vs.1.20 ±0.11 g respectively,P ＜0.05).Thet-value between the two groups were - 19.448 and - 17.307 respectively.Conclusions Reduced small intestinal motility is present in guinea pigs fed on a lithogenous diet,and may have a role in the pathogenesis of cholesterol gallstone formation.