Animals ; Child ; China ; Dairy Products ; Diet ; Health Promotion ; methods ; Health Status ; Humans ; Nutritional Status ; Nutritive Value

Objective To explore the influences of Jinganning decoction on the content of CYP2E1 and cytokine IL-6,TNF in rats models of alcohdic hepatic injury.Methos 72 male Wistar clean level rats were randomly divided into 6 groups:blank control group,Jiuganning drug toxicity test group,alcoholic hepatic disease model group,Yiganling treatment group,Jiuganning low dose group,and Jiuganning high dose group.Blank control group was treated with physiological saline;Jiuganning drug toxicity test group was treated with Jiuganning decoction to observe toxicity and side effects.Jiuganning low and high dose treatment group were treated with 17.5 g/kg and 23.5 g/kg crude drug.Yiganning treatment group were treated with 0.206 g/kg crude drug.After 4 weeks'treatment,the content of TNF,IL-6,MDA as well as the activity of CYP2E1 and SOD were measured.Results Compared with the alcoholic hepatic disease model group,the content of IL-6(F=46.281,9.101),TNF and the activity (F=62.537)of CYP2E1 of all treatment group were significantly improved(P＜0.01).The content of SOD(F=19.210)in the rats serum of all treatment group was significantly increased while the MDA(F=34.952)was decreased.All the indexes in the treatment group had significant differences with the alcoholic hepatic disease and model group(P＜0.01).Conclusions The mechanism of Jiuganning decoction can effectively reduce the content of CYP2E1 and IL-6,TNF-a,with the changes of cell physiopathology and the influences of relevant enzymes,reveals the functional routines of the decoction treating hepatic injury:anti-lipid peroxidative,adjusting cytokine's activity,protecting hepatocyte,palliating the hepatocyte inflammation,and easing fibration.

A tumor suppressor gene at 10q23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phosphatase activity, has been shown to play an important role in the pathogenesis of a variety of human cancers and sporadic tumor. In this paper, we reviewed the construction and function of PTEN, and the mechanism of activation in cancer especially in thyroid carcinoma.

Objective To study the ankle-brachial index of the diabetic gangrene. Methods ABI of the sixty cases with type 2 diabetes were measured. The results were divided into four groups: normal, gently abnormal moderate abnormal severely abnormal group. Results 30 cases were normal, occupying 50% (P＞0.05), gently and moderate abnormal attained 5 cases (8.33%) and 4 cases (6.67%) respectively, and the rests 21cases were severely abnormal, occupying 35% (P＞0.05).Conclusion The normal ABI was not always indicating type 2 diabetes without the gangrene or tendency.

Child ; Emergencies ; Female ; Humans ; Nutritional Sciences

Female ; Fertility ; Humans ; Nutritional Status

During the past 30 years, Alzheimer's disease (AD) drug R&D aiming at a variety of potential targets has undergone tremendous setback although a large amount of resources have been invested by pharmaceutical companies, governments, academic institutions and venture capitals globally. There is no doubt that uneasy early diagnosis, unsatisfying therapeutic strategies and genetic polymorphism of AD patients bringing variety of responses to the drugs contribute to the failure of AD drug therapy, but the most important reason might be that people have insufficient understanding of the very complex diseases including AD. Continuing to make efforts in the previous way to find AD drugs might not be a good way. Development of systems biomedicine opens an avenue to understand the disease networks and pursue multi-target drugs R&D based on systems pharmacology theory; neural stem cell transplantation, and neurogenesis affected by small molecules might bring new hope for AD therapy; discovery of new biomarkers of AD will help the study of the pathogenesis and diagnosis of the disease and finally the discovery of new types of AD drugs.
Alzheimer Disease ; drug therapy ; Biomedical Research ; trends ; Humans

Objective To evaluate the efficacy and safety of deoxyribonucleotide in intervention with wound healing.Methods A total of 144 patients above Type Ⅱ incision was included.All patients were received conventional therapy.And 72 cases in positive group were given thymopentin 1mg/d for 7 ～14 days,72 patients in treatment group were given deoxyribonucleotide 200mg/d for 7 ～ 14 days.Wounds were observed at 7,14,30 days,respectively.Results Postoperative infection rate(12.1％ vs 16.6％ vs 40％,P ＜ 0.05),pathogenic bacteria detection were decreased by both treatment and control groups.The 14 d complete healing rate (80％ vs 48.3 ％,P ＜ 0.05),weight gain [(2.1 ± 0.7) kg vs (0.6 ± 0.3) kg,P=0.016],clinical effect (89.3％ vs 61.3％,P =0.0018) of treatment group were higher than the control group.The 7 d wound area and complete healing time of treatment group were lower than the control group [(12.6 ±6.8)cm2 vs (18.7 ±7.1)cm2,P =0.018; (18.8 ± 11.2)d vs (21.4 ± 12.6)d,P =0.023].Deoxyribonucleotide can promote fibroblast proliferation and collagen production [(35.4 ± 7.6)ng/L vs (24.4 ± 6.9) ng/L,P =0.006].Conclusions Short-term application of deoxyribonucleotide and thymopentin can decrease postoperative infection through activating immune function.However,wound healing had no relationship with activating immune function seemly.Deoxyribonucleotide promotes wound healing through promoting fibroblast proliferation.

BACKGROUND:Pedicle screw is a good means for internal fixation and has been widely used in clinical practice. OBJECTIVE:To explore the factors influencing the fixation strength of pedicle screws, and to provide biomechanical basis for clinical selection of pedicle screws. METHODS:The recently published studies addressing the biomechanics of pedicle screws were retrieved, and those focusing on the influence of pedicle screw geometry, implantation technique, pedicle anatomical factor, vertebral bone density, screw manufacturing process and material properties on the fixation strength of pedicle screws were retrospectively analyzed, thus providing theoretical basis for clinical treatment. RESULTS AND CONCLUSION:Results showed that, the appearances of pedicle screws such as screw size, screw thread form and fatigue property are the main factors associated with the fixation strength, in addition, vertebral bone density, screw manufacturing process and material properties cannot be ignored. The screw withdrawal force and stability can be improved by increasing screw diameter, improving screw design, strengthening bone density, and modifying operations.

?AlM:To study the application of small incision surgery in free treatment for poverty alleviation in patients with cataract.?METHODS: Sixty patients (70 eyes) with high cataract with poverty free treatment from January 2010 to December 2013 in department of ophthalmology in our hospital were selected as study objects. electro cardio gram ( ECG ) and chest X - ray examination were performed. The small incision combined with intraocular lens ( lOL ) implantation operation was undergone. The patients were followed up for 3mo to observe and compare postoperative vision and diopter changes, and analyze the related complications.?RESULTS: The best visual acuity was 0. 6, while the lowest vision for hand 3mo after the operation, a total of 65 eyes ( 93%) vision was better than that before the operation: the eye axis less than 30mm ( 25. 87 ~29. 41mm) had 55 eyes, eye axis more than 30mm (30. 02~31. 47mm) had 10 eyes; and 5 eyes whose visual acuity had no significant changes.?CONCLUSlON: The small incision cataract treatment is simple, better curative effect and high safety, it is more suitable for free treatment in poverty alleviation cataract application.