Animals ; Child ; China ; Dairy Products ; Diet ; Health Promotion ; methods ; Health Status ; Humans ; Nutritional Status ; Nutritive Value

Objective To study the ankle-brachial index of the diabetic gangrene. Methods ABI of the sixty cases with type 2 diabetes were measured. The results were divided into four groups: normal, gently abnormal moderate abnormal severely abnormal group. Results 30 cases were normal, occupying 50% (P＞0.05), gently and moderate abnormal attained 5 cases (8.33%) and 4 cases (6.67%) respectively, and the rests 21cases were severely abnormal, occupying 35% (P＞0.05).Conclusion The normal ABI was not always indicating type 2 diabetes without the gangrene or tendency.

A tumor suppressor gene at 10q23.3, designated PTEN, encoding a dual specificity phosphatase with lipid and protein phosphatase activity, has been shown to play an important role in the pathogenesis of a variety of human cancers and sporadic tumor. In this paper, we reviewed the construction and function of PTEN, and the mechanism of activation in cancer especially in thyroid carcinoma.

Objective To explore the influences of Jinganning decoction on the content of CYP2E1 and cytokine IL-6,TNF in rats models of alcohdic hepatic injury.Methos 72 male Wistar clean level rats were randomly divided into 6 groups:blank control group,Jiuganning drug toxicity test group,alcoholic hepatic disease model group,Yiganling treatment group,Jiuganning low dose group,and Jiuganning high dose group.Blank control group was treated with physiological saline;Jiuganning drug toxicity test group was treated with Jiuganning decoction to observe toxicity and side effects.Jiuganning low and high dose treatment group were treated with 17.5 g/kg and 23.5 g/kg crude drug.Yiganning treatment group were treated with 0.206 g/kg crude drug.After 4 weeks'treatment,the content of TNF,IL-6,MDA as well as the activity of CYP2E1 and SOD were measured.Results Compared with the alcoholic hepatic disease model group,the content of IL-6(F=46.281,9.101),TNF and the activity (F=62.537)of CYP2E1 of all treatment group were significantly improved(P＜0.01).The content of SOD(F=19.210)in the rats serum of all treatment group was significantly increased while the MDA(F=34.952)was decreased.All the indexes in the treatment group had significant differences with the alcoholic hepatic disease and model group(P＜0.01).Conclusions The mechanism of Jiuganning decoction can effectively reduce the content of CYP2E1 and IL-6,TNF-a,with the changes of cell physiopathology and the influences of relevant enzymes,reveals the functional routines of the decoction treating hepatic injury:anti-lipid peroxidative,adjusting cytokine's activity,protecting hepatocyte,palliating the hepatocyte inflammation,and easing fibration.

Female ; Fertility ; Humans ; Nutritional Status

Child ; Emergencies ; Female ; Humans ; Nutritional Sciences

During the past 30 years, Alzheimer's disease (AD) drug R&D aiming at a variety of potential targets has undergone tremendous setback although a large amount of resources have been invested by pharmaceutical companies, governments, academic institutions and venture capitals globally. There is no doubt that uneasy early diagnosis, unsatisfying therapeutic strategies and genetic polymorphism of AD patients bringing variety of responses to the drugs contribute to the failure of AD drug therapy, but the most important reason might be that people have insufficient understanding of the very complex diseases including AD. Continuing to make efforts in the previous way to find AD drugs might not be a good way. Development of systems biomedicine opens an avenue to understand the disease networks and pursue multi-target drugs R&D based on systems pharmacology theory; neural stem cell transplantation, and neurogenesis affected by small molecules might bring new hope for AD therapy; discovery of new biomarkers of AD will help the study of the pathogenesis and diagnosis of the disease and finally the discovery of new types of AD drugs.
Alzheimer Disease ; drug therapy ; Biomedical Research ; trends ; Humans

OBJECTIVE: Differential cognition and evaluation of the scientific merit of free radical-induced aging theory in the explanation of aging mechanism.DATA SOURCES: Literatures about free radical-induced aging theory were searched in Medline and Embase by computer from April 1976 to October 2004 with searching words of "free radical, aging, dialectical" and the language of the articles was limited in English, the subjects were the elderly and aging animal.STUDY SELECTION: To select literatures about free radical-induced aging theory for preliminary examines. Quality evaluation mainly examined the authenticity of the data, whether the survey design was rigorous, whether the intervention process was strict, and whether statistical management was reasonable.DATA EXTRACTION: A total of 30 articles about the merit of free radical-induced aging theory in the explanation of aging mechanism were searched, of which 18 experiments were in accorded with the inclusive criteria. In the 12 excluded experiments, 7 articles were the repetitions of same study, and 5 articles were Meta analytic study.DATA SYNTHESIS: Comparative analysis was conducted in the experimental results of aging essence and the prolongation of maximum duration of life explained by free radical-induced aging theory.CONCLUSION: Free radical-induced aging theory has an important biomedical academic merit, but it does not successfully explain the fundamental reason of agingand the essence of aging process.

Ghrelin is a kind of brain-gut peptides,which integrates the body's digestive function and energy metabolism in the brain-gut axis.Recent studies showed that Ghrelin can be detected in breast milk.It is increasingly becoming the focus that Ghrelin from both maternal and perinatal neonates has special biological effects on the growth and development of newborns.such as stimulating the growth of fetal skin cells and the formation of bone,helping the catch-up growth of intrauterine growth restriction fetus after birth, regulating the glucose metabolism and promoting the fat synthesis of premature infants,and improving the maturation of neonatal immune system.This paper reviews the structure and physiological function of Ghrelin.as well as its effects on the neonatal growth and body weight regulation.

Objective To compare the curative effect and untoward effect of EGVB treatment with four different methods. Methods The clinical information of 160 EGVB patients were analyzed,40 cases were treated by octreotide combined with glonoin( A group) ,40 cases were treated by octreotide( B group) ,40 cases were treated by octreotide combined with pituitrin ( C group) , 40 cases were treated by pituitrin combined with glonoin ( D group). Results Curative effect and average hemostasis time of A and C group were better than B and D group, average transfusion of A and C group were less than B and D group, untoward effect incidence rate of A and B group were less than C and D group. Conclusion Octreotide combined with glonoin have satisfied curative effect for EGVB patients, and had less untoward effect,it was worth generalizing.