The purpose of this study was to compare the clinical results of guided tissue regeneration(GTR) using a resorbable barrier manufactured from an copolymer of polylactic acid (PLA) and polylactic-glycolic acid(PLGA) with those of nonresorbable ePTFE bdmer. Thirty two patients(25 to 59 years old) with one radiographically evident intrabony lesion of probing depth > or =6mm participated in a Gmonth controlled clinical trial. The subjects were randomly divided into three independent groups. The fist group(n=8) received a ePTFE barrier. The second group (n=12) received a resorbable PLA/PLGA barrier. The third group (n=12) received a resorbable PLA/PLGA barrier combined with an alloplastic bone graft. Plaque index (PI), gingival index(GI), probing depth(PD) , gingival recession, clinical attachment level(CAL), and tooth mobility were recorded prior to surgery and at 3,6 months postsurgery. Statistical tests used to analyze these data included independent t-test, paired t-test, one-way ANOVA. The results were as follows : 1. Probing depth was significantly reduced in all groups at 3,6 months postsurgery and there were not significant differences between groups. 2. Clinical attachment level was significantly increased in all groups at 3, 6 months postsurgery and there were not significant differences between groups. 3. There were not signifiicant differences in probing depth, clinical attachment level, gingival recession, tooth mobility between second group (PLA/PLGA barrier) and third group (PLA/RLGA barrier combined with alloplastic bone graft) 4. Tooth mobility was not significantly increased in all groups at 3,6 months postsurgery and there were not significant differences between groups. In conclusion, PLA/PLGA resorbable barrier has similar clinical potential to ePTFE barrier in GTR procedure of intrabony pockets under the present protocol.
Gingival Recession ; Guided Tissue Regeneration* ; Humans* ; Methods ; Tooth Mobility ; Transplants

The surface characteristics of titanium have been shown to have an important role in contact ossseointegration around the implant. Anodizing at high voltage produces microporous structure and increases thickness of surface titanium dioxide layer. The aim of present study was to analyse the response of rat calvarial osteoblast cell to commercially pure titanium and Ti-6Al-4V anodized in 0.06 mol/l beta-glycerophosphate and 0.03 mol/l sodium acetate. In this study, rat calvarial osteoblasts were used to assay for cell viability and cell proliferation on the implant surface at 1, 2, 4, 7 days. 1. Surface roughness was 1.256micrometer at 200V, and 1.745micrometer at 300V. 2. The thickness of titanium oxide layer was increased 1micrometer with the increase of 50V. 3. The proliferation rate of osteoblastic cells was increased with the increase of the surface roughness and the thickness of titanium oxide layer. 4. There was no difference in cell viability and cell proliferation between commercially pure titanium and Ti- 6Al-4V anodized at the same condition. In conclusion, the titanium surface modified by anodizing was biocompatible, produced enhanced osteoblastic response. The reasons of enhanced osteoblast response might be due to reduced metal ion release by thickened and stabilized titanium dioxide layer and microporous rough structures.
Rats ; Animals

Coronavirus disease 2019 (COVID-19) is a global pandemic that had affected more than eight million people worldwide by June 2020. Given the importance of the presence of diabetes mellitus (DM) for host immunity, we retrospectively evaluated the clinical characteristics and outcomes of moderate-to-severe COVID-19 in patients with diabetes.