Objective To explore the advantages and disadvantages of the double lumen endotracheal intubation and single -lumen endo-tracheal intubation and continuous carbon dioxide insufflation in thoracoscopic esophagectomy .Methods The clinical data of 90 patients in our department of thoracic surgery after thoracoscopic esophagectomy from January 2014 to April 2015 were analyzed .All patients were divid-ed into single-lumen endotracheal intubation (group A)and double lumen endotracheal intubation group (group B).The endotracheal intuba-tion time,operation time,incidence of pulmonary infection,intraoperative and postoperative PaO2,PaCO2,incidence of anastomotic fistula, hospitalization expenses ,length of hospital stay and the incidence of postoperative chylothorax between two groups were compared .Results The difference in intraoperative PaO2,PaCO2,incidence of pulmonary infection,endotracheal intubation time,operation time,hospitalization days and the hospitalization cost between two groups were statistical significance .The difference of the rest index between two groups were no statistical significance.Conclusion Group A has certain advantages in perioperative management ,hospitalization cost and so on,but has disadvantages in perioperative hypoxemia and carbon dioxide retention and acid -base balance disorders .

Objective To investigate the changes of serum estradiol (E2) and tumor necrosis factor (TNF)-αin endome-triosis (EMS) patients with pelvic pain, and their correlation thereof. Methods The serum levels of E2 and TNF-α were mea-sured with ELISA in 113 EMS patients with pelvic pain ( 37 cases in mild pain group, 41 cases in moderate pain group and 35 cases in severe pain group) and 30 healthy women without EMS (control group). Results There were no significant differences in the serum levels of E2 and TNF-α between mild pain group and normal control group. There were significantly higher levels of E2 and TNF-αin moderate and severe pain groups than those of mild pain group and normal control group. The serum levels of E2 and TNF-αwere significantly higher in severe pain group compared with those of moderate pain group (P<0.05). There was no correlation between serum levels of E2 and TNF-αin mild pain group. The serum levels of E2 and TNF-αwere positive-ly correlated between moderate pain group and severe pain group (P<0.05). Conclusion The increased E2 level can play a role in chronic pelvic pain of EMS by inducing macrophage to release TNF-α.

Acute kidney injury( AKI) is a variety of causes leading to rapid impaired renal function, causing glomerular filtration rate reduced,blood urea nitrogen elevated,serum creatinine increased,urine out-put decreased,resulting in the disorder of the human body environment,so the body can not maintain homeo-stasis. AKI increases the risk of mortality and chronic kidney disease in neonate. To understand the progress of AKI on diagnostic criteria,pathogenesis,early biomarker,treatment and prognosis,it is extremely important to guide clinical diagnosis and treatment,improve the outcome and reduce the mortality of AKI in neonate.

Cerebrovascular disease is currently one of the major diseases that result in the deaths of human.Its incidence elevates year by year,and there is a trend of younger.Stroke in young adult accounts for 25％ ～ 33％ in all stroke patients.Once a young man has a stroke,his quality of life will drop dramatically,and it will also bring a heavy burden to the family and society.Therefore,the etiologies of stroke in young adults should be summarized in order to achieve early diagnosis and early treatment.It is very important for improving of their prognoses.Cryptogenic stroke accounts for about 30％ in all strokes.The possible etiologies of cryptogenic stroke in young adults include heart diseases,arthritis,artery dissection,obstructive sleep apnea syndrome,and drug abuse,etc.

[Objective] To establish a method for the determination of geniposide in Jinzhi Jieyin Gargle by RP- HPLC. [ Methods ] SupelcosilTM LC - 18 (150 mm ?4.6 mm, 5?m) was used as the analytical column, methanol - water -phosphoric acid (25∶75∶0.12 ) as mobile phase and the detection wave - length at 240 run. [Results] Within the range of 0.175-1.84?g, geniposide showed a good linearity ( r = 0.9999 ). The average recovery was 99.93%(n=5, RSD = 1.16%). [Conclusion] This method can be used for the quality control of Jinzhi Jieyin Gargle.

Objective To investigate the prevalence of metabolic syndrome (MS) among residents in Shuimogou district of Urumqi city and to compare the differences between the Uygur and Han Populations. Methods Adopting cluster sampling, a survey of diabetes mellitus was conducted in Shuimogou district in June, 2008. Data of total 2420 subjects aged over 18 years with complete data, including background information of each individual, blood pressure, lipid profile, blood glucose and so on, were analyzed in this study. The criterion of the China Diabetes society (CDS) in 2004 was applied for diagnosis. Results The crude prevalence rates of MS were 12.85% in total, 14.91% in male and 7.39% in female, respectively. The age-standardized prevalence rates of MS were 9.93% in total, 13.58% in male and 6.11% in female. The prevalence rates of MS in male was higher than that in female (P0.05). The prevalence rates of components of MS were 43.31% for obesity, 30.08% for hypertension, 25.79% for hypertriglyceridemia and 16.28 % for hyperglycosemia. Among the four factors above, there were about 65% subjects who had at lest one abnormal factor according to the CDS criterion. Conclusion There were no differences in the prevalence rates of MS between the Uygur and Han populations. However, the prevalence rate of MS in male was higher than that in female. More than half subjects had at least one abnormal metabolic factor.

The pathogenesis of multiple sclerosis ( MS) involves alterations to multiple pathways and processes, which represent a significant challenge for developing more-effective therapies.In MS, abnormalities have been identified in several cytokine-signaling pathways, as well as those of other immune receptors.Among the downstream molecules implicated are Jak/Stat, NF-κb, ERK1/2, p38 or Jun/Fos, current MS drugs target some of these pathways.This article will with the aid of the latest research results of systems biology approaches that study pathway dysregulation in the process of MS development, targeting these relevant MS-signaling pathways, offers the opportunity to accelerate the development of novel individual or combination therapies for the future of new drug research.

BACKGROUND:Knee-parameter measurements play an important role in the designing of the knee prosthesis. Currently, we have more and more research of the total knee replacement, while uni-condylar knee replacement study is few. OBJECTIVE: To obtain the parameters of the normal femoral condyles and explore its correlation with osteotomy and prosthesis design of the knee joint during uni-condylar knee replacement. METHODS: Normal knee joints of 60 cases (60 knees) were selected. We measured the parameters by using thin-section CT scan and post-processing techniques, including arc diameter of the lowest point of the femoral condyle on the coronal plane, arc diameter of the distal point of the posterior condyle of the femur on the transverse plane, arc diameter of the distal point of the posterior condyle of the femur on the sagittal plane, and arc diameter of the lowest point of the femoral condyle on the sagittal plane, and analyzed the correlation with sex and height. RESULTS AND CONCLUSION:The diameter of the arc that passes through the lowest point of femoral medial condyle in the coronal plane was (42.685±1.389) mm. The diameter of the arc that passes through the farthest point of posterior of femoral medial condyle in the cross-section was (42.732±1.440) mm. The diameter of the arc that passes through the lowest point of femoral medial condyle on the sagittal plane was (45.473±1.332) mm. The diameter of the arc that passes through the farthest point of posterior of femoral medial condyle on the sagittal plane was (42.587±1.446) mm. The results illustrate that knee condyle related parameters were positively correlated with height. Parameters in males were significantly greater than in females. The diameter of the arc that passes through the lowest point of femoral medial condyle on the sagittal plane was significantly larger than that of the farthest point of femoral posterior medial condyle on the sagittal plane (P < 0.001). There was no significant difference among the diameter of the arc that passes through the lowest point of femoral medial condyle on the coronal plane, the diameter of the arc that passes through the farthest point of posterior of femoral medial condyle on the cross-section and that of the farthest point of femoral posterior medial condyle on the sagittal plane.

Objective To probe the cause,clinical and imaging findings of children's congenital pyriform sinus fistula (CPSF). Methods Clinical and radiographic data in 23 patients with children’s CPSF were analyzed retrospectively which were confirmed by pathology.Results 1 6 patients represented repeated swelling and pain in left anterior neck,6 of whom were misdiagnosed as thyroid abscess and suffered surgery.7 patients represented masses in left anterior neck.Ultrasound showed all patients with diffuse en-larged thyroid gland with uneven mass and separated liquid dark space or infection in deep neck soft tissue,and no CPSF was identi-fied.The subsequent esophageal barium meal confirmed the fistula in 8 patients,and other patients underwent further CT scan with image post-processing.CT showed clear fistula in 4,suspicious fistula in 7 and no fistula in 4,All fistulas were confirmed by the pa-thology.Conclusion The combination of ultrasound,esophagogram and CT with image post-processing can improve the diagnostic sensitivity and accuracy of CPSF.

Objective:To summarize the experience in the postopera ti ve management of free flap transfer for the repair of the defects in head and ne ck region. Methods:Thirty three free flaps were transfere d to repair head and neck defects.The factors that may influence the survive of the flaps,and the way that may be used to handle those problems were analyzed. Result: Thirty two of the thirty three free flaps surviv ed and one was lost. The overall free flap success rate was 97.0% .Thrombosis of vein developed in 2 patients. By flap salvage, one flap survived,the other ex perienced total failure. The total postoperative complication rate was 36.4% inc luding thrombosis,infection,bleeding,wound break and so on.Corresponding treatme nt was given and all the flaps were kept except one mentioned above. Conclution:The most common complications in free flaps transfer are v essel thrombosis and hematoma. Timely salvage can prevent the necrosis of the flaps