In the report of the definition and classification subcommittee of the International Dry Eye WorkShop (2007), inflammation was emphasized specially, and anti-inflammation therapy was also included in the treatment recommendations by severity level. Inflammation has been highly valued in the pathogenesis of dry eye recently. The management of dry eye through anti-inflammation therapy is also a hot point in recent years. What is the role of inflammation in the development of dry eye? This article mainly reviews the advancement of the study about their relevance in recent years.

Genetically modified organisms, as a high-tech product, break through the limitation of different organisms and create new organisms through gene implanting from other kinds of organisms. They not only bring great benefits to human beings but also bring some ethical issues including the effect on environment,the effect on human health,and the respect to hatural law.Moreover,this article argues some ethical issues during the process of commercialization and sale including how to maintain the consumers' benefits,the protection on researchers through potent right,the precautionary principle and label issues.

An analysis technique of steady state and stability for closed-loop PWM DC/DC switching converters is presented. Using this method, the closed-loop switching converter is transformed into an open-loop system. By means of the fact that in steady state, the two boundary values are equal in one switching period. The exponential matrix is evaluated by precise time-domain-integration method, and then the related curve between feedback duty cycle and the input one is obtained. Not only can the steady-state duty cycle be found from the curve, but also the stability and stable domain of the system. Compared with other methods, it features with simplicity and less calculation, and fit for numerical simulation and analysis for closed-loop switching converters. The simulation results of examples indicate the correctness of the presented method.

The efficacy of traditional Chinese medicine(TCM) is the summary for the effects of traditional Chinese medicine.The effect of traditional Chinese medical pharmacology is studying the interaction mechanism between TCM and body,using the modern technical methods and guiding by TCM theories.Most efficacies of TCM are identical with pharmacological effects.The clinical use of TCM pharmacy will give a full play of treatment only by guided with the theory of the concept of the whole and treatment based on syndrome differentiation and integrated with the efficacy of TCM and the principal compatibility of medicine.

Analysis was conducted and rights concerning teachers,students and patients in practice teaching was defined from the perspectives of medicine,pedagogy,ethnics and law through investigating on reasons leading to problems and conflicts in medical universities' practice right.Effective solutions were proposed from the examination of doctor' s qualification,law and pedagogy.Standardization and legalization of clinical teaching was promoted from the perspective of ethnics.

MicroRNA(miRNA) is a kind of small non-coding RNA which contents 18-25 nucleotide (nt). MiRNA plays an important role in human tumor of digestive system. Recently lots of research demonstrates that miRNA can act either as oncogenes or as tumor suppressor genes or sometimes as both. And many families of miRNAs'targets have been found. So the study of miRNA will supply a new way to the diagnosis and therapy of digestive diseases.

Objective:To discuss the relationship between blood-lipid change and acute cerebrovascular disease (ACVD) and tocompare the blood-lipid levels in the patients with cerebral hemorrhage (CH group) with those in the patients with cerebralinfarction (CI group). Methods:The blood-lipid levels in 300 patients with ACVD (ACVD group) and 100 patients withother system disease (control group) were tested with automatic biochemistry analysor and compared between the twogroups. Results:There were significant differences between ACVD group and control group as well as between CH group andCI group. Conclusion:Although there were blood-lipid metabolic disturbances in both CH and CI patients, their degrees weresignificantly different, which should be closely observed and controlled in clinic.

Objective To investigate the incidence of pregnancy complicated with myelodys- plastic syndrome(MDS)and the influence between pregnancy and MDS and to discuss the diagnosis, treatment and prognosis of pregnancy complicated with MDS.Methods Six pregnant patients complicated with MDS from Jan,1992 to Dec,1997 were retrospectively analysed and literature was reviewed.Results The incidence of pregnancy complicated with MDS was 0.66‰ and 24% of women with MDS were pregnant women.Therapeutic induction of labor was done in 2 cases because of severe MDS.Two complicated with PIH,and three complicated with postpartum haemorrage in six cases.Blood transfusion was necessary in all cases for treatment of severe anemia in pregnancy. MDS may remit after delivery.The use of corticosteroid before termination of pregnancy and prophy- lactic antibiotics after delivery is important.Conclusions It is important to prevent haemorrage and infection in the management of pregnaney complicated with MDS.

Objective To explore the pathogenesis of autism by observation of changes of brain-derived neurotrophic factor(BDNF) positive neurons and the morphology of pyramidal cells in hippocampal CA1 region,and provide theoretical evidence for the therapeutic schedule.Methods Animal model of autism was obtained by Schneider method.Using the immunohistochemistry methods and image analysis,the number of BDNF positive neurons was examined in hippocampal CA1 region of the autism model rats and the normal rats,and the changes of pyramidal cell were observed in hippocampal CA1 region after HE staining.Results The numbers of BDNF positive neurons in the hippocampal CA1 region of the autism model rats were more than those of the normal rats (5.00 ±1.60 vs 3.00 ± 1.04,t =3.63,P =0.0015).The morphology of pyramidal cells showed that the pyramidal cells of the autism model rats in hippocampal CA1 region had apoptosis.Conclusion The occurrence of autism may be related to the changes of BDNF and the morphology of pyramidal cells in hippocampal CA1 region.

The morbidity and mortality of tumors of digestive system is much higher in recent years .Realizing diagnosis of early phase tumors can improve the surgical resection rate and prolong survival time of patients .Compared with traditional diagnosis methods, multiphoton microscopy has got an obvious improvement in the penetration depth .Furthermore, phototoxicity and photo-bleaching has been largely reduced .Combining with the second harmonic microscopy , the change of collagen fibers can be observed in the organization.MPM can achieve early diagnosis of cancer at the cellular level .Therefore, multiphoton microscopy , with the imaging characteristics of unique high resolution , real-time, nondestructive , deeply spectral resolution , is of great potential in the diagnosis of early stage tumors of digestive system .Based on the latest research results , this review summarizes the latest progress of multiphoton microscopy diagnosing early phase of gastrointestinal tumor .