ObjectiveTo evaluate the accuracy of the vascular ultrasound testing technique on detecting large arterial lesions in neck. MethodsVascular ultrasound testing and digital substraction angiography(DSA) were performed on 75 arteries in 53 consecutive patients with chronic cerebral ischemia, transient ischemic attack(TIA) or cerebral infarction.The sensitivity, specificity, and accuracy of vascular ultrasound testing on moderate stenosis(50%—69%), severe stenosis(70%—99%),or occlusion of arterial lesions in neck were analysed by means of cross tabulation, using DSA as the standard of reference. ResultsThe sensitivity, specificity and accuracy of vascular ultrasound testing on arterial lesions of moderate stenosis, severe stenosis and occlusion were 85.7%,78.9%,84.0%;90.2%,88.2%,89.3%;93.3%,95.0%,94.6%,respectively.The complete corresponding rate between the two type of tests was 73.3%. ConclusionThe vascular ultrasound testing technique shows high accuracy on detecting large arterial lesions, especially on severe stenosis or occlusion in neck. It can be applied extensively in prevention and treatment of cerebrovascular diseases.

More and more attention tend to the application of intensity modulated radiation therapy (IMRT) treatment of malignant cancer.The accuracy of the radiotherapy is raising because of the increased radiosensitivity of bone marrow.Imaging modality quantified the distributions of bone marrow.,which could further reduce the volume to avoid.Bone marrow-sparing intensity-modulated radiotherapy can reduce the pelvic bone marrow irradiation volume,which may reduce the probability of acute bone marrow inhibit.It is worthy of application widely.

Family hospital bed information (FBH) system running on tablet personal computer (PC) was developed from the analysis of 36 general practitioner′s requirements.The system shared information with the hospital information system (HIS).The establishment of FHB information management system and the mode of reviewing and editing medical records,prescription and personal health record on tablet PC improved the management efficiency and quality of FHB.

Objective · To detect gingival thickness of the anterior teeth region of Han nationality youths in Shanghai by cone-beam computerized tomography (CBCT), and evaluate its clinical application feasibility and the gingival biotype. Methods · Firstly, gingival thickness in the same site (5 participators, 30 sites) was detected by bone sounding and CBCT respectively, and the data were compared. A total of 30 participators with healthy gingival were recruited to the study and examined by the CBCT, the gingival thickness of selected sites (330 sites) was assessed and compared. All the subjects were examined by the experienced doctors and classified into three groups, thick-type middle-type and thin-type. Gingival thickness range and the proportion of every type were obtained. All data analyses were performed using SPSS 13.0. Results · There was no statistical difference in the thickness of gingival measured by bone sounding and CBCT (P>0.05). The main gingival biotypes of Han nationality youths in Shanghai were thin-type and middle-type. The average gingival thickness of upper central incisors [(1.32±0.15) mm] was larger than those of upper lateral incisors [(1.07±0.16) mm,P=0.000] and upper canines [(1.08±0.18) mm, P=0.000]. Conclusion · CBCT is feasible for detecting gingival thickness. Gingival thickness of the upper central incisors is significantly larger than those of upper lateral incisors and upper canines. The main gingival biotype of Han nationality youths in Shanghai is middle-type, the proportion of thick-type is least.

Objective To observe clinical manifestations and immune responses in rabbit models of syphilis established by inoculation with Treponema pallidum through different routes. Methods A total of 20 rabbits were randomly and equally divided into two groups: testis-inoculated group injected with Treponema pallidum (Tp) suspensions into the testes, back-inoculated group intracutaneously injected with Tp suspensions at six sites on the shaved back. All the rabbits received a single injection with the total injection amount of Tp (Nichols strains)being 2 × 107 in both groups. Clinical symptoms and immune responses were evaluated in both groups every other day. Statistical analysis was carried out by a two-sample t-test and rank sum test with the SPSS 20.0 software. Results On day 8 after the inoculation, the testes of rabbits in the testis-inoculated group started to swell with induration, and the swelling was most severe during days 13 - 16. Afterwards, the testes gradually diminished, and returned to normal in size without swelling or hardening on day 28. No skin lesions occurred in the other sites in the testis-inoculated group within 2 months after the inoculation. Erythematous swelling occurred at inoculation sites on day 7 after inoculation in the back-inoculated group, which was most obvious between days 15 and 45. Moreover, cartilage-like indurated ulcers were observed at 12 inoculation sites in 3 rabbits in the back-inoculated group, and dark-field examination of the ulcers showed the presence of Tp. There was a significant difference in the time required for the severity of lesions to peak between the testis-inoculated group and back-inoculated group (14.50 ± 1.08 days vs. 29.00 ± 10.30 days, t=5.02, P<0.05). Rank sum test showed significant differences in the distribution of highest RPR titers between the two groups(P<0.05), and RPR titers were higher in the testis-inoculated group than in the back-inoculated group. Conclusions The injection of Tp suspensions at different sites can cause different clinical symptoms and immune responses in rabbits. RPR turned positive earlier with a higher titer in the testis-inoculated group compared with the back-inoculated group. The clinical manifestations in the back-inoculated group were similar to those of chancre in primary syphilis in human.

Objective:To raise awareness of acute myeloid leukemia (AML) combined with lymphoblastic lymphoma (LBL) in children.Methods:The clinical characteristics, diagnostic methods, treatment plans and prognosis of a child with AML combined with LBL who was admitted to the First Affiliated Hospital of Zhengzhou University in April 2016 were retrospectively analyzed, and the relevant literature was reviewed.Results:The patient was an 11-year-old boy with fever, abnormal hemogram and cervical lymph node enlargement as clinical manifestations. A biopsy of the cervical lymph node was performed and the patient was diagnosed as T-lymphoblastic lymphoma (T-LBL). After the bone marrow morphology, immunology, cytogenetics and molecular biology (MICM) classification examination, the diagnosis was AML. The patient met the diagnostic criteria of two diseases at the same time, and thus he was confirmed as AML combined with T-LBL. AML chemotherapy regimens were given, and the patient achieved complete remission and disease-free survived.Conclusions:AML with LBL is extremely rare in children. The diagnosis mainly depends on MICM classification examination of bone marrow and pathological examination of lymph nodes. There is currently no standard treatment scheme, and the prognosis is extremely poor. AML chemotherapy followed by bridging hematopoietic stem cell transplantation is the best treatment option for these patients.

Objective:To observe the analgesic effect of Yunzhi polysaccharopeptide (PSP) and analyze its mechanism. Methods: The hot plate test in mice and the tail stimulation vocalization test in rats were used.Results: PSP administered po at a dose of 1.0 g/kg for 7 days could produce a significant analgesic effect, which could last for more than two hours. The analgesic effect of PSP disappeared after lesion of mediobasal hypothalamus. Conclusions: PSP could elicit a central analgesic effect.

Objective:To detect mutations of exons 5 and exons 8 of PTEN gene in oral squamous cell carcinoma(OSCC),and to explore the relationship between gene mutations and development of OSCC.Methods: Mutations of exons 5 and exons 8 of PTEN gene were detected by polymerase chain reaction-single strand conformation polymorphism(PCR-SSCP).Results: The whole sequences of exons 5 and exons 8 of PTEN gene of all cases of OSCC were expanded.There was no mutation in exons 5 and exons 8 of PTEN gene of all cases of OSCC.Conclusion: There is no mutation in exon 5 and exon 8 of PTEN gene in OSCC.This might show that there is no correlation between mutations in exon 5 and exon 8 of PTEN gene and the development of OSCC.

Objective: To investigate the measles antibody level among residents in Quzhou City, Zhejiang Province in 2018, so as to provide the evidence for improving the measles control strategy. Methods: The permanent residents aged 0 to 59 years were randomly sampled from 10 townships ( streets ) in Kecheng District and Changshan County of Quzhou City. Residents' demographics and vaccination of measles-containing vaccine ( MCV ) were collected, and serum anti- measles IgG antibody was detected using enzyme-linked immunosorbent assay ( ELISA ). The positive rate, protective rate and geometric mean concentration (GMC) of anti-measles antibody were estimated. Results: A total of 606 residents were tested, with a male to female ratio of 0.83∶1. The subjects had a median age ( interquartile range ) of 17.36 ( 29.07 ) years, and 399 residents ( 65.84% ) had a vaccination history of MCV. The positive rate, protective rate and GMC of anti-measles IgG antibody were 94.88%, 48.68%, and 784.51 ( 95%CI: 731.14-841.40) mIU/mL, respectively. The positive rate of anti-measles IgG antibody was higher in men than in women ( 97.08% vs. 93.07%, χ2=4.968, P=0.026 ), and the protection rate was lower in men than in women ( 44.16% vs. 52.41%, χ2=4.089, P=0.043 ). The protective rate and GMC of anti-measles IgG antibody showed a“U”-shaped distribution with age, and a low protective rate was seen in residents aged 10 to 39 years ( 23.53% to 46.67% ), which the GMC of anti-measles IgG antibody that did not reach the protective level. A total of 233 residents at age of 15 years and below had with a history of two-dose MCV vaccination, and the positive rate ( χ2trend=7.260, P=0.007 ), protective rate ( χ2trend=12.756, P<0.001 ) and GMC ( rs=-0.289, P<0.001 ) of anti-measles IgG antibody presented a tendency towards a reduction with time <1 to 11 years after vaccination of the last dose of MCV. Conclusions A high positive rate of anti-measles antibody was detected among residents in Quzhou City in 2018; however, the protection rate of anti-measles antibody was low among residents at ages of 10 to 39 years. The coverage of MCV vaccination is recommended to be improved among residents at ages of 10 to 39 years in Quzhou City.

Objective To discuss causes and treatment outcomes of radial nerve injury related to hinged external fixators applied to the elbow,enhance understanding of the injury and thereby reduce its clinical incidence.Methods The study involved five cases who experienced radial nerve injury in the wake of application of unilateral hinged external fixators to the elbow.Exploration and neurolysis was perfomed at 3-12 weeks after injury since no signs of nerve recovery.Afterwards,follow-up was made for all cases.Results Causes of radial nerve injury were as follows:proximal humerus Schanz screws stretched and compressed radial nerve by tethering soft tissues into cicatricial bands in two cases; distal humerus Schanz screws compressed radial nerve by tethering soft tissues adjacent to radial nerve to cicatricial bands in one case; distal humerus Schanz screws compressed radial nerve in motion of the elbow by tethering thickened intermuscular septa and further forcing the enlargement of muscle force in two cases.Forces of muscles supplied by radius nerve reached fourth or fifth rank at postoperative one-year follow-up.Conclusions Radial nerve is vulnerable in the application of unilateral hinged external fixators to the elbow due to its special path and relative stability.Accordingly,injury to radial nerve can be reduced and even avoided by knowing its anatomy features and standardizing the operation in use of external fixators.Exploration and treatment immediately after the confirmation of radial nerve injury can achieve good prognosis.