1.Research on the methods and application prospects of condition monitoring for medical devices
Xiangfei YIN ; Bing YANG ; Hehua ZHANG
China Medical Equipment 2016;13(4):126-128,129
This paper introduces the present situation of condition monitoring of medical devices, states main methods of condition monitoring and puts forward the application strategies in hospitals briefly.
2.Effect of rocuronium on spectral entropy during induction of general anesthesia in patients of Uygur nationality
Fang JI ; Bing ZHANG ; Yahua LIU ; Jifeng YIN ; Zhixin XU
Chinese Journal of Anesthesiology 2011;31(6):661-663
Objective To investigate the effect of rocuronium on spectral entropy during induction of general anesthesia in patients of Uygur nstionality. Methods Forty ASA Ⅰ or Ⅱ patients (Uygur nationality) of both sexes, aged 20-50 yr, weighing 45-70 kg, undergoing elective surgery under general anesthesia, were divided into 2 groups ( n = 20 each): normal saline (NS) group and rocuronium group (group R). Anesthesia was induced with target-controlled infusion of propofol. The initial target plasma concentration wan net at 2 μg/ml. The concentration wan then increased by 0.5 μg/ml every 4 min until response entropy (RE) was decreased to 45 and maintained for 4 min. When the plasma concentration was equal to the effect-site concentration, iv rocuronium 0.6 mg/kg was injected in group R, while group NS received the equal volume of NS instead. Fentanyl 3 μg/kg was injected intravenously at 3 min after recuronium administration. The patients were tracheal intubated and mechanically ventilated. State entropy (SE) and RE were recorded immediately before induction (baseline, To), before rocuronium administration (T1), 2 main after rocuronium administration (T2) and at 0, 1, 2 and 3 min after intubation (T3-6). The difference between RE and SE wan calculated. Results The RE value at T3 and T4 and the difference between RE and SE at T2.5 were significantly lower in group R than in group NS ( P < 0.05). Conclusion Rocuronium can decrease the RE value and degree of increase in the difference between RE and SE during induction of general anesthesia in patients of Uygur nationality, which may affect the accuracy of spectral entropy in monitoring the depth of anesthesia.
3.Determination of Tamoxifen and Letrozole in Sewage by Solid Phase Extraction and Ultra Performance Liquid Chromatography/ Tandem Mass Spectrometry
Xianjun LIU ; Jing ZHANG ; Bing SHAO ; Jie YIN
Chinese Journal of Analytical Chemistry 2010;38(2):214-218
Tamoxifen and letrozole are two of the most effective pharmaceuticals mainly used in hormonal dependent) breast cancer therapy. A trace analytical method using ultra performance liquid chromatography/tandem mass spectrometry(UPLC-MS/MS) was developed to simultaneously detect these two drugs in both influent) and effluent of municipal sewage treatment plant. Sewage samples were passed through an Oasis HLB cartridge, then an amino solid phase extraction cartridge was connected with Oasis HLB cartridge. Target compounds) was firstly eluted with 6 mL methanol and then 3 mL methanol was used to elute the amino solid phase extraction cartridge, collected and pooled the elutants. After concentration, target compounds were separated) on a BEH C_(18)) column using a gradient elution profile with a mobile phase consisting of 0.1% formic acid aqueous) solution and acetonitrile and detected by an electro spray ionization tandem mass spectrometry with multiple reactions monitoring(MRM). Satisfactory linearity(R~2>0.997) was obtained over the range of 1.0-100 μg/L) and 0.1-100 μg/L for tamoxifen and letrozole, respectively, with limits of quantification(LOQ) of 1.0 and 0.1 ng/L. Mean recoveries of two target compounds(spiked in sewage samples at three concentration levels) ranged from 68.8% to 103.0%, with relative standard deviations(RSD) less than 15%. This method can be applied for the analysis of target drugs sewage samples.
5.The Training and Practice for the Advanced Study Doctor Major in the Clinic Orthodontics
Bing YU ; Jiangtian HU ; Yali LIU ; Xiaorong ZHANG ; Kang YIN
Journal of Kunming Medical University 2007;0(S2):-
To improve the composit application knowledge and clinic performance ability of the advanced study doctor.We take the clinc doctors as study object,using various teaching ways to discuss the methods and quality of orthodontic doctors.Through making rigorou teaching planing,seting reasonable courses,and strict clinic operational training,the quality of teaching is visible improved.This teaching system is worth to make use and extend.
6.Construction, Expression and Evaluation of the System Reporting Streptococcus pneumoniae Virulent Gene by GFP in vivo
Bao-De CHEN ; Yi-Bing YIN ; Xue-Mei ZHANG ;
Microbiology 1992;0(05):-
Streptococcus pneumoniae(S.pn) is an opportunity pathogenic bacteria,environmental factors play a key role in the pathogenicity of S.pn. It is important to study virulent gene in vivo. The S.pn suicide plasmid containing gfp reporter was constructed by fusing the genes pneumolysin and gfp,in which gfp is an excellent molecule probe in vivo. The plasmid was integrated to No.22 S.pn by homologous recombination. The recombinant S.pn was gained and evaluated in aspects of fluorescence excitation, biological character and physio-activity. The results showed it is efficient and available to report the expression of virulent genes in vivo and in vitro, which will provide a new easy method for evaluating and screening the virulent genes of S.pn in vivo.
7.The exploration of pharmaceutical botany extracurricular activities practice
Jiankui ZHANG ; Haibo YIN ; Yang LIU ; Qi ZHANG ; Yanping XING ; Liang XU ; Bing WANG
Chinese Journal of Medical Education Research 2015;14(6):604-607
Liaoning University of Traditional Chinese Medicine has conducted pharmaceutical botany extracurricular activities such as the experiment skill competition,fieldwork,specimen preparation,resources investigation,database construction,pharmaceutical plants cultivating and participating in scientific research projects etc.These activities have improved the students' learning enthusiasm,strengthened the effect of first classroom teaching,and have played a positive role especially in improving students' experimental skills and cultivating their innovative thinking and abilities,and improving teachers' quality.
8.Application of Case-based Learning (CBL) Method in Clinical Practice of Internal Medicine
Bing GUAN ; Fang YIN ; Fan YANG ; Ying ZHANG ; Xubin WEI ; Xiangling ZHANG
Journal of Kunming Medical University 2013;(10):152-154
Objective To investigate the effect of Case Based Learning (CBL) method in clinical practice of internal medicine. Methods 88 clinical medicine students were divided into CBL teaching group and traditional teaching group. Traditional teaching method was introduced to traditional teaching group while CBL teaching method was carried out in the other. The test papers and questionnaires were analyzed in both groups. Result The students in CBL teaching group mastered internal medicine knowledge better than the other group. Conclusion CBL teaching mode helps improve the overall teaching quality of internal medical in clinical practice,and the interns' interest in learning and their clinical practice ability can be greatly enhanced.
9.The study of multivoxel 1 H-MRS in detection of different hippocampal regions of Alzheimer’s disease
Fei CHEN ; Bing ZHANG ; Yun XU ; Xin ZHANG ; Zhenyu YIN ; Ming LI ; Huiting WANG ; Bin ZHU
Journal of Practical Radiology 2014;(4):552-556,579
Objective To investigate the metabolic changes and the metabolites distribution of different hippocampal regions (head,body and tail)in patients with Alzheimer’s disease (AD)using 1 H-MRS for early diagnosis.Methods The hippocampal multivoxel 1H-MRS at 3.0 T was scanned in 30 patients with AD and other 30 normal cognitive elders (NC)as contrast.The data obtained were processed at a workstation.The hippocampus was divided into 3 parts (head,body and tail),and the ratios of N-acetylaspartate (NAA)/creatine (Cr),myoinositol (MI)/Cr and MI/NAA were calculated respectively.The metabolite ratios and distribution changes were compared between group AD and NC.Results Compared with the group NC,the NAA/Cr in group AD in bilateral hippocampal body and tail was decreased,whereas the MI/Cr and MI/NAA in bilateral body and tail,MI/NAA in left head were opposite (P<0.01).In group NC,the NAA/Cr was gradually decreased from the bilateral hippocampal heads to tails (P<0.01),however,the MI/NAA was opposite (P<0.01).No distribution differences in every metabolic ratios of bilateral hippocam-pus were found in AD group (P>0.05).Conclusion Metabolic changes and disappearance of the normal distribution in different hippocampal regions detected by 1 H-MRS provide helpful clues for early diagnosis of the AD.
10.Preliminary clinical study on endovascular treatment of posterior inferior cerebellar artery aneurysms
Bing ZHAO ; Ming ZHONG ; Xianxi TAN ; Kuang ZHENG ; Mingsheng ZHANG ; Jian YIN ; Wengen HE
Chinese Journal of Radiology 2009;43(6):634-636
Objective To study the methods and results of endovascular treatment of posterior inferior cerebellar artery (PICA) aneurysms. Methods Twenty-one patients with PICA aneurysms were treated with endovascular treatment. The locations of aneurysm on PICA were evaluated through the DSA. Eight patients received single coil embolization, 5 received liquid Glue embolization, 2 received coil embolization combined with liquid Glue, 2 received coil embolization assisted with stents, and 4 underwent ocelasion of the parent PICA. Outcome was evaluated with the Glasgow outcome scale (COS). Results There were complete (100%) occlusion in 5 patients, near complete (>90% ) occlusion in 2, and incomplete (85%) occlusion in 1 in single coil embolization. Seven patients with Glue embolization (n = 5 ) or combination with coils ( n = 2 ) exhibited complete ( 100% ) occlusion. There were near complete ( >90% ) occlusion in 2 cases with coil assisted with stents. Complete occlusion of the parent PICA was achieved in 3 patients, and near complete occlusion of PICA in one case. One patient suffered from new neurological deficits, and one patient treated with coils and stents died. None of the patients suffered from re-bleeding. These patients received follow-up during a mean period of (22±8) months. Overall long-term outcome was good ( GOS score 4 or 5 ) in 17 patients, poor ( COS score 2 or 3) in 3, and fatal ( GOS score 1 ) in one case. Conclusions According to the location of aneurysms on PICA, aneurysms can be effectively and safely treated with endovaecular embolization.