Objective The flow of talents personnel is one of the main impetus of societal progress,it is also particularly important for the development of universities.this paper would discuss possible influence factors of the Science and technology talent retention in Xinjiang Universities from the perspective of personnel policy adjustment.Methods Literature review,field survey and expert interview were carried out to understand the personnel policies and existed problems of talent retention in Xinjiang,identifying and analyzing problems,bring in experiences,cases and ideas from other universities both in China and abroad,proposing reforms with focusing on the reconstruction of both talent personnel policy and platforms.Results Through a series of comparative analysis,we discuss the causes and adjustment mechanism of the brain drain in Xinjiang colleges and universities.Conclusions Xinjiang universities should take flexible measurements in employing mechanism reform,the construction of hard and soft environment on the unique path to get out of Xinjiang to attract all kinds of talents talent retention.