Objective To systematically evaluate the efficacy of the lienal polypeptide injection combined with chemotherapy or radiotherapy on the short-term efficacy, Karnofsky score, immune function and adverse reactions in treatment of various cancers. Methods The databases of PubMed, Embase, Cochrane Library, CNKI, Wanfang and VIP were retrieved from database establishing time to January 2017, and the randomized controlled trials (RCT) about lienal polypeptide injection combined with radiotherapy or chemotherapy in the treatment of advanced cancer were collected. The quality assessment was conducted and eligible trials were included in the Meta-analysis. Results A total of 23 articles were included, involving 1658 patients. The patients were divided into treatment group (lienal polypeptide injection combined with chemotherapy or radiotherapy, 842 cases) and control group (chemotherapy or radiotherapy alone, 816 cases). Results of Meta-analysis showed that the short-term effective rate (RR = 1.20, 95％ CI 1.07-1.33, P = 0.001), the improvement rate of Karnofsky score (RR = 1.77, 95％ CI 1.43-2.19, P < 0.05) and immune function related indicators: CD3+ (MD = 9.48, 95％ CI 6.76-12.20, P < 0.01), CD4+ (MD = 7.54, 95％ CI 5.38-9.71, P < 0.01), NK cells (MD = 4.47, 95％CI 3.45-5.48, P < 0.01) and CD4 +/CD8 + (MD = 0.33, 95％ CI 0.25-0.42, P < 0.01) in the treatment group were significantly higher than those in the control group, and the differences were statistically significant. The incidence of nausea and vomiting (RR = 0.51, 95％ CI 0.35-0.73, P = 0.0002) and bone marrow suppression (RR = 0.41, 95％ CI 0.25, 0.68, P = 0.0006) in the treatment group were significantly lower than those in the control group, and the differences were statisticallysignificant. There was no statistical difference in CD8+ level and the incidence of neurotoxicity, diarrhea, oral mucositis and hepatic injury between the two groups (all P > 0.05). Conclusion Lienal polypeptide injection combined with radiotherapy or chemotherapy is superior to conventional radiotherapy or chemotherapy alone in the treatment of cancer, which can improve the quality of life of patients with tumors, reduce the incidence of nausea and vomiting and bone marrow suppression induced by the treatment.

Objective:To systematically review the relationship between CYP3A4*1G gene polymorphism and the analgesic effect of fentanyl-related drugs.Methods:The related literature about the effect of gene polymorphism on analgesic effect of fentanyl-related drugs published at home and abroad was searched in PubMed, Embase, Cochrane Library, CNKI, Wanfang and China Biomedical Literature databases from database establishment to August 2019. According to the inclusion and exclusion criteria, two researchers screened the literature independently, extracted the data and evaluated the methodological quality. Data analysis was performed by Review Manager 5.1 software.Results:Six literature was enrolled with 1 050 cases, including 543 cases of wild-type homozygote (CC), 437 cases of heterozygote (CG) and 70 cases of mutant homozygote (GG). The results showed that there was no significant difference in pain score between the three groups in a pairwise comparison at 24 hours after operation (all P > 0.05), but the consumption of fentanyl-related drugs in GG group was lower than that in CC group and CG group, and the differences were statistically significant [GG group vs. CC group: standardized mean difference (SMD) = -0.78, 95% CI -1.03- -0.52, P<0.01; GG group vs. CG group: SMD = -0.61, 95% CI -0.87- -0.35, P<0.01]. Conclusions:CYP3A4*1G gene polymorphism can affect the postoperative analgesia effect of fentanyl-related drugs. With the same analgesic effect, the consumption of fentanyl-related drugs in GG patients is reduced.

Objective To investigate the value of three-dimensional amide proton transfer(3D APT)imaging and multi-model diffusion weighted imaging(DWI)in evaluating the histological grade of cervical squamous cell carcinoma(CSCC).Methods A total of 54 patients with CSCC at different grades were prospectively included.All subjects underwent pelvic 3D APT and multi-b-value DWI sequences on a 3.0T MR scanner.Two radiologists blindly measured the amide proton transfer(APT)values of all continuous layers of the lesion,the apparent diffusion coefficient(ADC)of the mono-exponential-model of DWI,the ture-diffusion coefficient(D),pseudo-diffusion coefficient(D*),perfusion fraction(f)of intravoxel incoherent motion(IVIM)imaging,and the mean diffusivity(MD)and mean diffusion kurtosis(MK)values of diffusion kurtosis imaging(DKI).The receiver operating characteristic(ROC)curve was used to analyze the efficacy of each parameter in identifying different pathological grades of CSCC.Results The APT mean signal intensity(SImean),APT maximum signal intensity(SImax)and maximum mean diffusion kurtosis(MKmax)values of the high-grade group were statistically higher than those of the low-grade group,and the minimum apparent diffusion coefficient(ADCmin),minimum ture-diffusion coefficient(Dmin),and minimum mean diffusivity(MDmin)values were statistically lower than those of the low-grade group(P＜0.05).The area under the curve(AUC)increased after the combination of APT parameters and DWI parameters,which was obviously higher than that of a single parameter(P＜0.05).Conclusion Both APT and multi-model DWI are helpful to identify the degree of differentiation of CSCC,and the diagnostic value of combining the two is higher.

Objective:To explore the dynamic temporal variability of brain functional networks in individuals with internet gaming disorder(IGD)using dynamic functional connectivity density(dFCD).Methods:From January 2019 to December 2021, resting-state functional magnetic resonance imaging data were recruited from 55 patients with IGD and demographically matched 50 healthy controls.Data analysis was performed by IBM SPSS 21.0 software. The functional connectivity density(FCD) combined with sliding window analysis was employed to calculate the temporal variability of global functional connectivity.FCD in whole brain was further devided into ipsilateral and cotralateral parts.The temporal variability of dFCD was further quantified utilizing the standard deviations of whole brain, intra-, and inter-hemispheric FCD. Finally, Pearson correlation analysis was performed between dFCD variance in differential brain regions and clinical behaviors.Results:The inter-hemispheric dFCD in the left posterior cingulate cortex(-0.16±0.24) and the left precuneus(-0.08±0.23) in patients with IGD were lower that those in healthy controls(0.002±0.260, 0.12±0.36)( t=-3.502, -4.160, both P<0.05).And the intra-hemispheric dFCD in the left calcarine, the left precuneus, and the left posterior cingulate cortex in patients with IGD were lower that those in healthy controls( t=-3.809, -4.360, -3.561, all P<0.05).Moreover, abnormal global dFCD variability of the calcarine and ipsilateral dFCD variability of the PCC negatively correlated with the severity of IGD( r=-0.380, -0.413, both P<0.05). Conclusion:Patients with IGD show intra-and inter-hemispheric dFCD differences in the visual attention network and default mode network, which may respond to the underlying neurobiological basis for the presence of cognitive dysfunction and impaired concentration.

As a type of experiential psychotherapy,Satir communication model can help the individual system and the family system achieve a state from dysfunction to healthy function,which can enrich the intervention connotation of family support and provide a new direction for the realization of full-life circle care.This paper aims to introduce the concept,core elements,common treatment techniques,application and effects,current challenges and relevant suggestions of Satir communication model in the nursing field from the perspective of family support,in order to provide references for the localization development and clinical integration of Satir communication model in the field of nursing in China.

Objective To explore the effect of Jinhoujian spray on postoperative sore throat (POST) after implantation of streamlined liner of pharyngeal airway (SLIPA) in general anesthesia. Methods A total of 100 patients undergoing lower limb fracture surgery with laryngeal mask general anesthesia in Xuchang Central Hospital, Henan University of Science and Technology from January 1, 2024, to May 31, 2024 were randomly divided into Jinhoujian spray group (Jinhoujian group) and lidocaine aerosol group (lidocaine group), with 50 cases in each group. Jinhoujian spray and lidocaine aerosol were applied to both sides of the laryngeal mask sealing cover, and after intravenous induction of general anesthesia, the same anesthesiologist inserted the laryngeal mask using a blind probing standard method. Mean arterial pressure (MAP) and heart rate (HR) were compared between the two groups at different time points: before laryngeal mask insertion (T₀), immediately after insertion (T₁), 3 minutes after insertion (T₂), 5 minutes after insertion (T₃), 10 minutes after insertion (T₄), immediately after mask removal (T₅), 3 minutes after removal (T₆), and 5 minutes after removal (T₇). The incidences of stress responses (coughing, airway spasm, agitation, nausea and vomiting) and adverse reactions (tongue numbness, arytenoid joint dislocation, dysphagia, restricted protective reflexes, and pharyngeal arch injury) after laryngeal mask removal were compared between the two groups. The numeric rating scale (NRS) at 0.5 h, and NRS, hoarseness, and extubation reaction at 24 h after mask removal were compared between the two groups. Results There were no statistically significant differences in baseline data and MAP and HR values at each time point (T_0-7) between the two groups. Compared with the lidocaine group, the patients in Jinhoujian group had a lower incidence of nausea and vomiting after laryngeal mask removal (P＝0.021). There was no statistically significant difference in the numeric rating scale (NRS) score 0.5 h after laryngeal mask removal between the two groups. Compared to the lidocaine group, the patients in Jinhoujian group had significantly lower scores of NRS (P＝0.027), Prince-Henry (P＝0.002), and oral mucositis (P＝0.026) 24 h after laryngeal mask removal . Conclusions Jinhoujian spray can effectively reduce incidence of postoperative nausea and vomiting, alleviate POST and oral mucositis 24 h after laryngeal mask removal, improving patient comfort after lower limb fracture surgery.