1.Effect of Oxandrolone Therapy in Short Stature.
Yil Sub LEE ; Soo Young LEE ; Duk Hi KIM
Journal of the Korean Pediatric Society 1989;32(9):1273-1281
No abstract available.
Oxandrolone*
3.Neurosonographic Follow-up Study in Low Weight Infants.
Yil Sub LEE ; Chul LEE ; Ran NAMGUNG ; Dong Gwan HAN ; Ki Keun OH
Journal of the Korean Pediatric Society 1988;31(12):1573-1579
No abstract available.
Follow-Up Studies*
;
Humans
;
Infant*
4.A case of Gaucher's Disease Diagnosed by beta-Glucosidase Enzyme Deficiency.
Hwan Gyn PARK ; Yil Sub LEE ; Chang Hyun YANG ; Chang Ho HONG ; Sung Kyu LEE ; Kyung Soon SONG ; Hyeon Joo JEONG
Journal of the Korean Pediatric Society 1990;33(4):514-521
No abstract available.
beta-Glucosidase*
;
Gaucher Disease*
5.A Case of Incidental Retroperitoneal Ganglioneuroma
Weon Yil SONG ; Moon Won LEE ; In Sub HAN ; Young Joo PARK ; Sung Yong HAN ; Dong Hoon BAEK ; Bong Eun LEE ; Gwang Ha KIM
The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2019;19(3):198-201
Ganglioneuroma is a rare benign tumor originating from the neural crest cells. It occurs most commonly in the retroperitoneum and posterior mediastinum and is often found in the neck or pelvis. It may be detected incidentally or detected by pressure effects on the adjacent structures due to its slow growth. However, some functional tumors may secrete catecholamines and present with some clinical symptoms. Complete surgical excision is the treatment of choice. We describe here a case of a retroperitoneal ganglioneuroma which was removed completely by surgery. We review the literature and discuss the clinical features of a ganglioneuroma.
Catecholamines
;
Ganglioneuroma
;
Mediastinum
;
Neck
;
Neural Crest
;
Pelvis
6.Phagocytosis of serum-and IgG-opsonized zymos an particles induces apoptosis through superoxide but not nitric oxide in macrophage J774A.1.
Jun Sub KIM ; Hyeok Yil KWON ; Won Ho CHOI ; Chan Young JEON ; Jong Il KIM ; Jaebong KIM ; Jae Yong LEE ; Yong Sun KIM ; Jae Bong PARK
Experimental & Molecular Medicine 2003;35(3):211-221
Phagocytosis of serum- and IgG-opsonized zymosan (SOZ and IOZ, respectively) particles into J774A.1 macrophages induced apoptosis of the cells, accompanied by the expression of p21(WAF1), one of cyclin-dependent protein kinase (CDK) inhibitors. Furthermore, phagocytosis of SOZ and IOZ particles into macophages induced superoxide formation. Tat-superoxide dismutase (SOD), which is readily transduced into the cells using Tat-domain, protected the cells from the apoptosis induced by phagocytosis of SOZ and IOZ particles. lipopolysaccharide (LPS)/interferon-gamma (IFN-gamma) also caused the apoptosis of the cells. However, Tat-SOD could not protect the cells from LPS/IFN-gamma induced apoptosis, suggesting that apoptosis mechanisms involved are different from each other. In the present study, we determined the amounts of nitric oxide (NO) produced by SOZ, IOZ, and LPS/IFN-gamma, and found that SOZ and IOZ did not induce the generation of NO in macrophages, whereas LPS/ IFN-gamma did. The apoptosis due to phagocytosis was accompanied with the release of cytochrome c from mitochondrial membrane to cytosolic fraction. Furthermore, SOZ and IOZ induced the cleavage of procasapase-3 (35 kDa) to give rise to an active caspase-3 (20 kDa), which was blocked by Tat- SOD but not by 2-phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl 3-oxide (PTIO), a scavenger of NO. On the other hand, LPS/IFN-gamma caused the activation of procaspase-3, which was blocked by PTIO but not by Tat-SOD. Taken together, phagocytosis of SOZ and IOZ particles induced apoptosis through superoxide but not NO in macrophages, accompanied with the release of cytochrome c and the activation of caspase-3.
Apoptosis/*immunology
;
Caspases/metabolism
;
Cell Line
;
Cyclins/biosynthesis
;
Cytochromes c/metabolism
;
Immunoglobulin G/*immunology
;
Interferon Type II/pharmacology
;
Lipopolysaccharides/pharmacology
;
Macrophages/*immunology/metabolism
;
Nitric Oxide/*metabolism
;
Opsonins/immunology
;
Phagocytosis/*physiology
;
Superoxide Dismutase/metabolism
;
Superoxides/*metabolism
;
Zymosan