MicroRNAs (miRNAs) are a small noncoding family of 22 ut RNAs that play an important role in the negative regulation of gene expression at the post-transcriptional level by base pairing to the 3'untranslated region of target messenger RNAs.miRNAs are involved in a variety of basic processes,such as cell proliferation and apoptosis,metabolism and signaling pathways.A lot of studies have indeed described the aberrant expression of miRNAs in human tumors and have investigated their potential role as oncogenes or tumor suppressor genes,depending on the targets they regulate.Furthermore,more and more studies have demonstrated that an important role of miRNAs in anticancer drug resistance and miRNA expression profiling can correlate with the development of anticancer drug resistance.A systematic and intensive study on the mechanisms of miRNA in anticancer drug resistance will provide us a strong rationale for the development of miRNA-based therapeutic strategies aiming to overcome cancer cell resistance.This paper has reviewed the recent development of miRNAs involved in anticancer drug resistance.

OBJECTIVE To investigate the cause and and prevention experience of lung infection in the aged patients with gastrogavage at home.METHODS Retrospective analysis of lung infection was proceeded in 108 aged patients with gastrogavage at home during three years.RESULTS Among 108 patients with gastrogavage at home 83 patients developed infection in which 69 patients developed lung infection.For the aged patients with gastrogavage at home,inspiration and increasing incidence of retrograde infection from stomach to pharynx and lower respiratory tract were the main causes in developing lung infection.Moreover the lower immunity status,catching cold,changing the stomach tube not on time were the related risk factors in developing lung infection.CONCLUSIONS Enhancing the prevention of respiratory tract infection,increasing the nutrition,changing the stomach tube in time and prevention education would effectively decrease the incidence of infection and enhance the rehabilitation.

Based on my training experience in the United States,here introduced the situation of diabetes education and management in the United States,diabetes educator certification and the education program of outpatients and inpatients. This information can provide advice to improve the current status of diabetes education in China.

Chimeric antigen receptor (CAR) T cell shows its significant therapeutic effect in part of leukemia and lymphomas, which indicates that transgenic adoptive cellular immunotherapy may be one of the breakthroughs in treatment of solid tumors and blood diseases. The functional inhibition of CAR endogenous cells in the tumor microenvironment , molecular biology function of molecules, difficulties of CAR T cells in clinical application and the solutions , how to improve the clinical efficacy and to reduce toxic side effects for future cancer immunotherapy in clinic are reviewed in this paper.

Medical social work is a new arising occupation that provides professional medical service for patients in hospitals and communities based on the development of new medical mode,playing critical role in the therapeutic rehabilitation of certain diseases.Tumor diseases,especially malignant tumors,are serious hazards to human life and health,thus require special medical treatment and therapeutic rehabilitation due to their specific characteristics.Therefore,intervention of medical social work is of irreplaceable significance in the therapeutic rehabilitation of tumor diseases,promoting the realization of rehabilitation,soothing physical pains,providing psychological support,lengthening life expansion,enhancing the living quality of tumor sufferers,and assisting them better to regress to normal social life.

0.99).The IL-2 activity of control sample of our laboratory was determined according to recom-binant human IL-2 standard,the ability of IL-2 induced by rat and mouse spleen cells was compared, and the parameters of IL-2 induced by rat spleen cells were detected.The partially purified rat IL-2 was obtained through ammonium sulfate precipitation, gel filtration and chromatography.

Neutrophil gelatinase associated lipocalin(NGAL),also known as lipocalin 2,has close relationship with human neoplasias,which is up-regulated in a number of malignancy and involves in the process of tumor development.But it appears to exist paradoxical effects attributed to NGAL in human neoplasias.For instance,through protecting MMP9 from autodegradation,NGAL has a clear pro-tumoral and pro-metastatic effect,as has already been observed in breast cancer and esophageal cancer.However,on the contrary,for pancreatic cancer and ovarian cancer,NGAL can inhibit FAK phosphorylation and vascular epidermal growth factor synthesis,having an anti-tumoral and anti-metastatic effect.This review summarizes the current knowledge about the dual effects of NGAL in the process of tumor development,and attempts to explore the possible underlyins mechanism.

Objective　To evaluate the effect of vascular endothelial growth factor (VEGF) on tumor angiogenesis, and its usage in tumor therapy. Methods　The recent literatures about VEGF and angiogenesis were reviewed and analyzed. The advances of VEGF study were summarized. The effects of anti-angiogenesis in tumor biological therapy were introduced.Results　Angiogenesis had been identified as an important factor for promoting tumor growth. VEGF was a basic and pivotal factor in tumor angiogenesis. The anti-angiogenesis treatments aimed at VEGF, including the applications of VEGF inhibitor and gene therapy of adenovirus medium, had got great progress. Conclusion　 VEGF is a leading factor of tumor angiogenesis, the anti-angiogenesis therapy aimed at VEGF has probably provided a new chance to malignant tumor treatment.

Eighty simple obesity patients were treated by electoacupuncturing Tianshu(ST 25), Shuidao(ST 28), Shuifen(CV 9), Guanyuan(CV 4), Daheng(SP 15), Huaroumen(ST 24),Daimai (GB 26), Quchi(LI 11), Hegu(LI 4), Liangqiu(ST 34) and Zusanli(ST 36). The results showed remarkable effect in 14 cases, middle effect in 38 cases, common effect in 23 cases and failure in 5 cases.

Theauthor treated 148 cases of hiccup by finger-pressing Yifeng (TE 17). After one treatment, 97cases were cured; 34 cases were cured after 2-3 treatments, 6 cases were cured after over 4 treatments; and 11 cases obtained no effect. The total effective rate was 92.6%.