Objective To study the characteristics of EEG after tramsient ischemic attack and to offer reference for screening procedure of aircrew and astronaut selection. Method The dominant frequency uncertainty of alpha band EEG in 12 pilots(males; age 30±5) with transient ischemic episodes in middle cerebral artery(MCA) territories and in 20 normal healthy pilots was analyzed with frequency-fluctuation analysis. Result The dominant probability of the main frequency coinciding with sites affected by transient ischaemic attack(TIA) in patient pilots was higher than that in healthy pilots (P<0.01),and the dominant probability ratio logarithmic index I≥0 in all patient pilots with normal EEG, but I<0 in all healthy pilots. It was also found that not only I≥0, but the second component shifted to lower frequency(8 Hz) in patients with slight focal EEG alterations,i.e. slowing of frequency. The relative entropy values (percentage) were decreased significantly in pilots with TIA as compared with healthy pilots (P＜0.05). Conclusion The dominant frequency uncertainty analysis of alpha band showed clear superiority of computerized evaluation over routine visual assessment for the diagnosis of minor cerebral ischemia. It offers not only a possibility of studying pathophysiological functional parameter, but also the reference for screening procedure in aircrew and astronaut selection.

Objective To investigate the health information literacy level of breast cancer patients,and discuss its influence on the network knowledge acquisition.Methods A total of 1130 breast cancer patients from four tertiary comprehensive hospitals in Zhengzhou were studied by using the general data questionnaire, the health information literacy self-rating depression scale and the network knowledge acquisition questionnaire. The cross-sectional study was used in the research.Results Breast cancer patients who had certain health information literacy level accounted for 32.9% (372/1130). The health information application was the dimension with the lowest literacy level 8.6% (97/1130). The health information literacy of patients living in cities,having a higher education level and having a disease course longer than five years,was relatively high (P<0.05). The breast cancer patients mainly searched the professional medical websites,and the contents were mainly about therapeutic schedule,pharmacy scheme,symptoms,complications and other contents. 62.6% of such patients were suspicious of the network information and would re-verify it. Patients having no health information literacy mainly searched the profitable commercial charging websites,and the contents were mainly about diet guide, exercise training and hospitals. 54.4% of such patients were convinced of the network information. Trust attitudes of the patients in two groups towards the network knowledge were obviously different (P<0.05).Conclusions The health information literacy level of breast cancer patients is relatively low. The clinic medical workers should conduct personalized training and guidance based on the condition of health information literacy of breast cancer patients,in order to improve the patients′ ability to acquire network knowledge and increase patients′ execution force in medical decisions.

Objective To investigate the immune status characteristics of primary ITP patients with abnor-mal auto-antibodies. Methods A total of 110 patients were enrolled in our study,who were admitted in Fu-Xing Hospital affiliated to Capital Medical University from January 2001 to July 2015.According to whether the patients have autoimmune diseases and the presence of auto-antibodies,we divided the patients into 3 groups,including the primary ITP with abnormal auto-antibodies(PITP-ANA)group,the primary ITP(PITP)group and the second-ary ITP(SITP)group.We compared the T-cell subsets,regulatory T cells,B lymphocytes,changes of immunoglob-ulin and bone marrow biopsy and cytology of patients among the three groups,retrospectively. Results The per-centage of CD3+T cells(61.72 ± 10.60)% in PITP-ANA group was lower than that in PITP group(69.57 ± 11.99)%. The percentage of CD8+T lymphocyte(24.00 ± 7.67)% was significantly lower than that of PITP group (30.59 ± 11.08)%(P<0.05).The proportion of Treg in PITP group,PITP-ANA group and SITP group were(6.12 ± 1.41)%,(7.50 ± 2.76)% and(8.49 ± 2.47)%,respectively,with statistically significant differences.The ra-tio of CD19+T cell in PITP-ANA group(25.75 ± 9.98)%was significantly higher than that in PITP group(16.16 ± 8.19)%(P < 0.01). The concentration of IgG、IgA、κ light chain and λ light chain in PITP group,PITP-ANA group and SITP group showed an upward trend and the highest level was in the SITP group,with statistically signifi-cant differences among the three groups. A variety of abnormal auto-antibodies could be found in both PITP-ANA group and SITP group. Conclusions We consider that the immune function abnormity of patients in PITP-ANA group were worse than that in PITP group,because the concentration of immunoglobulin,the percentage of B lym-phocyte and Treg ratio are higher in than those in PITP group.

Objective To investigate the clinical status of social avoidance and distress in chemotherapy patients after breast cancer surgery, so as to provide reference for psychological intervention. Methods A total of 300 cases of breast cancer patients who received chemotherapy in the Affiliated Tumor Hospital of Zhengzhou University from February 2016 to March 2017 were selected by convenience sampling method. The self-designed general situation questionnaire, Body Image after Brest Cancer Questionnaire (BIBCQ) and Social Avoidance and Distress Scale (SADS) were used in the investigation. Multi-factor hierarchical regression analysis was used to analyze the influencing factors. Results A total of 300 questionnaires were distributed, and 272 valid questionnaires were collected. The total scores of BIBCQ and SADS were (106.53±19.38) and (19.36±4.22) respectively, and the total score of SADS was positively correlated with the total score of BIBCQ (r=0.283, P<0.01). The results of single factor analysis indicated that the difference of SADS score among different ages, education level, percapita income, operation type, cancer staging and chemotherapy time in the chemotherapy patients after breast cancer surgery were statistically significant (t=28.17, 40.64, 23.21, 9.98, 27.79, 61.11; P<0.01). Hierarchical regression analysis showed that age, education level, percapita income, operation type,cancer staging, chemotherapy time, susceptibility, shame, restriction, body concern, clairvoyance, and limb concern were the factors affecting the social avoidance and distress of breast cancer patients after surgery (P<0.05). Conclusions Poor physical image of patients with chemotherapy after breast cancer is an important reason of lack of social function, which suggests that medical staff can enhance their social confidence and adaptability by strengthening the cognitive level of the patients' self image.

A 27-year-old male was admitted to the Xijing Hospital in August 2018 due to unprovoked severe thoracodynia with palpitations, shortness of breath and chest tightness. Computed tomography angiography showed a type A aortic dissection. Genetic testing based on next-generation sequencing for 15 genes associated with hereditary aortic diseases and Sanger sequencing validation revealed a heterozygous missense mutation c.998G>T (p.Gly333Val) in the COL3A1 gene. Sanger sequencing verification of family members confirmed that the mutation c.998G>T co-segregated with the patient′s phenotype in this family. That mutation was classified as "likely pathogenic" according to American College of Medical Genetics and Genomics standards and guidelines for genetic variant classification. Carriers of this mutation can be definitively diagnosed with "vascular Ehlers-Danlos syndrome". After the diagnosis was clarified, symptomatic treatment was given to the patient, but the disease progressed rapidly. The patient discontinued treatment and died shortly after being discharged. In this study, we found a new variant in the COL3A1 gene, expanding the mutation spectrum of this gene.