Objective:To evaluate the effects of maxillary protraction with or without rapid maxillary expansion in the treatment of Class Ⅲ malocclusion by Meta-Analysis.Methods:The randomized controlled trail,quasi-randomized controlled trail and the clinical controlled trail about the treatment of Class Ⅲ malocclusion by protraction with or without expansion were searched in the database of Cochrane Library,Embase,PubMed,Medline,CBM,Wan Fang,CNKI,VIP.2 authors qualified and extracted the data independently.Then the Meta-analysis was performed by using the RevMan 5.3 software.Results:7 studies with 228 cases were included,114 cases were treated by maxillary protraction with expansion and the other 114 cases by maxillary protraction without expansion.The Meta-analysis showed that:there was no significant difference in SNA,SNB,ANB and SN-PP except ANS-Me,U1-NA,SN-MP.A favorable improvement of the sagittal relationship between maxillary and mandibular was observed by using protraction whether with expansion or not.The expansion did not shorten the course of treatment,but it lowered the inclination of upper incisors,resulting in more clockwise rotation of mandibular plane and increase of the facial vertical dimension.Conclusion:Maxillary protraction with rapid maxillary expansion can be used in the treatment of class Ⅲ malocclusion with incisor labioclination.

Red blood cell transfusion is an important method to treat anemia of prematurity. HoWever,there are 3 areas of controversy:(1)complications associated With red blood cell transfusion in preterm infants;(2)indications of red blood cell transfusion in preterm infants;(3)Which kind of red blood cell products is more suitable for preterm infants. In recent years,With the deepening of research,these problems above have made some neW progress and they have been applied to clinic. The implementation of these ideas and measures makes the premature infants With anemia get reasonable treatment,and reduces incidence of complications associated With red blood cell transfusion in preterm infants,and improves the prognosis of those sick preterm infants. NoW,the neW progress of red blood cell transfusion in preterm infants Was revieWed.

Objective: To evaluate the change of tooth root volume and length after rapid maxillary expansion by CBCT three dimensional reconstruction method. Methods: 33 patients underwent rapid maxillary expansion were examined by CBCT before and after treatment. The CBCT images of the first,second premolars and the first molars were segmented and reconstructed by Mimics image processing software for the analysis of the changes of root volume and length. All data were analyzed by SPSS software statistically. Results: After maxillary expansion,all root volumes were reduced(P ＜ 0. 05),more reduction was observed in anchorage teeth than in non-anchorage teeth(P ＜ 0. 05). The length of most teeth roots was not decreased(P＞ 0. 05) except the buccal and distal roots of the first molars(P ＜ 0. 05). Conclusion: Rapid maxillary expansion may result in root resorption and this resorption is mainly based on the volume decrease.

Objective To compare dental and skeletal changes after rapid maxillary expansion in patients with different bone ages.Methods Thirty-seven patients in different growth period were divided into three groups according to cervical vertebral maturation (CVM).There were 13 patients in the growth acceleration group,13 patients in growth peak group,and 11 patients in growth deceleration group.Conebeam computed tomography(CBCT) images were segmented and reconstructed using Mimics image processing software to assess the change of palatal morphology before and after treatment.Statistical analysis was carried out using SPSS 17.0 software.Results After the expansion the posterior teeth and alveolar bone were tilted and the mid-palatal suture was opened in all three groups.The first molar angle in the three groups decreased by 2.66°±1.04°,3.53°±0.81° and 12.32°± 1.64°,respectively and no significant difference was found between the acceleration group and the peak group (P ＞ 0.05),but the changes in the acceleration group and the peak groups were significantly less than that in the deceleration group (P＜0.05).The palatal angle in the three groups increased by 6.01°±2.06°,4.79°± 1.31° and 6.73°± 1.71°,respectively and no significant difference was found between the acceleration group and the deceleration group (P ＞ 0.05),but the changes in the acceleration group and the deceleration group were significantly greater than that in the peak group (P ＜ 0.05).The palatal cemento-enamel junction (CEJ) width,the middle palate width and the mid-palatal suture width in the three groups increased by (7.37± 1.31),(6.68± 0.72) and (5.13± 1.42) mm;(5.72±1.68),(4.82± 1.66) and (3.42± 1.15) mm;(3.14±0.45),(2.98±0.51) and (0.96±0.83) mm,respectively and no significant difference was found between the acceleration group and the peak group (P ＞ 0.05),but the changes in the acceleration group and the peak group were significantly greater than that in the deceleration group (P ＜ 0.05).Conclusions The mid-palatal suture could be opened in patients in different CVM period.More skeletal and less dental effects were found in patients in the growth acceleration and peek group than in those in the growth deceleration group and the inclination of the alveolar bone could be avoided to a greater degree in patients in the growth peek group.

[Objective] To investigate the clinical characteristics of patients who underwent multiple platelet transfusions (≥2 times) in Suzhou over the past 5 years (2017-2022), as to provide new insights for patients requiring long-term and substantial platelet transfusions. [Methods] A retrospective analysis was conducted on the type of diseases, volume and frequency of platelet transfusions in patients who were hospitalized in Suzhou and received multiple (≥2 times) apheresis platelet transfusions from August 2017 to August 2022. Compatibility transfusions were also performed for a subset of acute myeloid leukaemia (AML) patients who completed HLA antibody testing and genotyping. [Results] From 2017 to 2022, the clinical consumption of platelets in Suzhou has increased annually (P<0.001), and patients who received apheresis platelets were mainly concentrated in hematological diseases represented by hematopoietic or lymphoid tissue tumors, especially AML patients (48.81%, 1 188/2 434). The age group with the highest per capita number of transfusions among AML patients was predominantly 21-30 years old (25 times per person). After genotype-compatible transfusion for eligible AML patients, the CCI significantly increased (P<0.001). [Conclusion] For male AML patients aged 21-30 and 61-70 in Suzhou, conducting platelet antibody screening and genetic testing before platelet transfusion can improve the efficiency of transfusion, reduce the incidence of PTR, and save blood resources through personalized matching transfusions.

Aluminum is a light metal which is rich in the earth's crust and widely used. Recently, the adverse health effects of environmental and occupational aluminum exposure on human have attracted more and more attention. Aluminum exposure has toxic effects on the central nervous system and is believed to be closely related to the development and progression of Alzheimer's disease. The neurotoxic mechanism of aluminum is complex, especially the role of regulated cell death (RCD) in aluminum-induced neuronal death remains to be further studied. RCD refers to all modes of cell death regulated by multiple intracellular signal transduction pathways under physiological and pathological conditions, including apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis. This review summarized the morphological characteristics and mechanisms of each RCD mode in the process of aluminum-induced neuronal death, and discussed the relationship and transformation between different RCD modes, providing a new scientific basis for future studies on the treatment and intervention of neurotoxicity induced by aluminum exposure.