OBJECTIVE To investigate the drug resistance of infection due to Pseudomonas aeruginosa.METHODS Totally 269 strains of P.aeruginosa derived from the clinical infection from Jan 2005 to Jun 2006 were analyzed according to the requirements described in the National Regulations on Clinical Laboratory Operations.The bacteria were identified by the automated analyzer VITEK-32 and the drug resistance was analyzed with the K-B test and PEMS3.1.RESULTS Drug sensitive rate of P.aeruginosa to imipenem,piperacillin/tazobactam,amikacin and tobramycin was the highest(86.6%,85.5%,87.0%,and 82.5%,respectively);to levofloxacin,ceftazidime,ciprofloxacin,gentamicin and cefepime was 77%,72.5%,72.5%,72.1%,and 70.4%,respectively.Drug sensitive rate of P.aeruginosa to other antibiotics was