Objective To investigate the effect of alprostadil injection on serum CRP, IL-6 and TNF-alpha and prognosis in patients with acute cerebral infarction.Methods 80 cases of patients with acute cerebral infarction from February 2014 to February 2016 in Ningbo Yinzhou People's Hospital were selected,all patients were randomly divided into two groups, the control group 40 cases, the conventional treatment of acute cerebral infarction;40 cases in the observation group, with alprostadil injection on the basis of control group.The levels of serum CRP, IL-6 and TNF-αwere observed before and after treatment, and the NIHSS and Barthel index score and the curative effect after treatment were observed.Results Compared with before treatment, no significant change after treatment of serum CRP, IL-6 and TNF-αlevels in the control group,the serum CRP, IL-6 and TNF-αlevels decreased significantly in the observation group ( P <0.05 ) , and significantly lower than the control group ( P <0.05 ).Compared with before treatment, NIHSS score decreased after treatment in two groups (P <0.05),Barthel index (P <0.05) score increased, NIHSS score in observation group was significantly lower than the control group (P<0.05), Barthel index score was significantly higher than the control group (P<0.05).After treatment,the effective rate of the observation group was 95%, which was significantly higher than that of the control group 72.5% ( P <0.05 ) . Conclusion Alprostadil injection treatment of acute cerebral infarction, can effectively reduce the patient's serum CRP, IL-6 and TNF-αlevels, reduce brain damage, can improve the curative effect, improve the prognosis.

Objective To explore crossed cerebellar diaschisis (CCD) in cerebral gliomas with three dimensional arterialspin-labeling (3D ASL) perfusion MRI.Methods The images of 31 patients with cerebral gliomas and 31 normal subjects were retrospectively analyzed.The cerebral blood flow (CBF) were measured with 3D ASL technology,and the asymmetry index (AI) of cerebellar hemispheric CBF value changes were calculated and compared in patients.And the relationship between the AI values of cerebellar hemispheric and the AI values of tumor region in cerebral hemispheric,tumor histological grade and size were investigated.Results Compared with tumor ipsilateral cerebellar hemisphere of supratentorial glioma,the CBF value of contralateral cerebellar hemisphere significantly reduced (t=5.04,P＜0.01),and the AI values of cerebellar hemispheric in patients obviously increased compared to normal subjects (t=4.13,P＜0.01).But there was no significant difference in the AI values of cerebellum between high grade and low grade gliomas (t=1.31,P＞0.05).In cerebral gliomas patients,there was no significant correlation between the AI values of cerebellar hemispheres and the AI values of cerebral hemisphere (tumor:r=-0.28;tumor parenchyma:r=-0.24;tumor plus edema:r=-0.19,all P＞0.05),and tumor size (r=0.18,P＞0.05).Conclusion Cerebral glioma can cause CCD phenomenon,and 3D ASL is able to quantitatively assess the degree of cerebellar hypoperfusion noninvasively.This phenomenon may not be associated with tumor histological grade,size and the AI values of cerebral hemispheric.