1.Autologous peripheral blood CD34+ stem cells transplanted into 100 patients with advanced cirrhosis.
Yutong YAO ; Lanyun LUO ; Hua XUE ; Le LUO ; Haibo ZOU ; Guan WANG ; Zhiming AN ; Ming ZHONG ; Xiaobing HUANG ; Yifan ZHU ; Lingling WEI ; Maozhu YANG ; Tian ZHANG ; Ping XIE ; Gang XU ; Shaoping DENG ; Xiaolun HUANG
Chinese Journal of Hepatology 2014;22(9):667-670
OBJECTIVETo investigate whether transplantation of autologous peripheral blood CD34+ stem cells is a viable approach for treating patients with advanced cirrhosis,which is currently hindered by a shortage in liver donors.
METHODSA total of 100 patients with advanced cirrhosis and who had failed to respond to conservative therapy were recruited for transplantation of autologous peripheral blood CD34+ stem cells.The success of transplantation was investigated 6-and 12-months later by measuring markers of liver biosynthesis function (coagulation,albumin level,indocyanine green clearance,Child-Pugh score) and assessing pathological changes (Knodell score) and morphologic changes in the liver tissue.Complications were also recorded during follow-up.
RESULTSThe 1-year cumulative survival rate was 100%. Fifty-two patients with massive ascites showed gradual reduction and disappearance of the ascites.Four patients experienced upper gastrointestinal bleeding and three patients developed with hepatic encephalopathy (I-II degree) at 3 months post-transplantation.All patients showed significantly improved liver biosynthesis function,liver elasticity and Knodell score after transplantation (P less than 0.05).
CONCLUSIONAutologous peripheral blood CD34+ stem cell transplantation is a safe and effective treatment for advanced cirrhosis,and has high cost-benefit since it improves liver function,liver histology,and quality of life.
Ascites ; Humans ; Liver Cirrhosis ; therapy ; Quality of Life ; Stem Cell Transplantation ; Transplantation, Autologous ; Treatment Outcome
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