Objective To observe the effects of high-fat diet on insulin sensitivity in rats. Methods Normal rats were fed with equicalorical high-fat diet and then treated with troglitazone. Glucose-insulin tolerance test was used to measure insulin sensitivity, blood pressure, blood glucose, insulin, endothelin, lipid, tissue glycogen and triglyceride levels. Results high-fat diet had no effect on body weight gain and blood pressure. Fasting and postprandial blood glucose levels were similar among the different groups. The levels of blood insulin, triglyceride, cholesterol and endothelin increased markedly, and the decrease in tissue glycogen level was also found. high-fat feeding caused insulin resistance after 4 weeks (K 5.63 vs. control 7.77, P

Objective To analyze the clinical features of sarcoidosis for improving the recognition of the articular manifestations of sarcoidosis.Methods The clinical data of 63 patients with sarcoidosis confirmed by biopsy were retrospectively analyzed.Results In 13 patients with sarcoidosis articular manifestations appeared (20 6%).Seven patients with sarcoidosis showed arthritis.Five patients of them showed oligoarthritis that was asymmetric and affected especially knees,ankles and ivrists.Two patients of them showed polyarthritis.Six patients with sarcoidosis showed arthralgia.Conclusion The articular manifestations of sarcoidosis may be divided into 3 types which are oligoarthritis,polyarthritis and arthralgia.The articular manifestations of sarcoidosis are of no specific characteristics.The diagnotic possibility of sarcoidosis should be considered for the joint involvements.

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is a syndrome associated with many conditions, including malignant neoplasms. One case T-cell malignant lymphoma whose first manifestation was RS3PE syndrome is reported, and the related literature is reviewed. RS3PE syndrome can be classified as primary and secondary one. The secondary RS3PE syndrome may not be a specific disease, and its prognosis depends on the primary disorders. The RS3PE syndrome associated with malignant neoplasms is called paraneoplastic RS3PE syndrome. Systemic symptoms and signs, eosinophilia and high lactate dehydrogenase (LDH) may indicate the possible presence of malignant lymphoma.

Objective To analyze the relationship between the clinical features and the dysfunction and derangement of knee osteoarthritis(OA),in order to improve the understanding of knee OA.Methods Clinical data including symptoms,physical signs,X-ray,arthroscopical findings,pathologic changes,preopera-tive and postoperative diagnosis,treatment and curative effects from206post-arthroscopy patients with OA were analyzed retrospectively.Results The common physical signs were tenderness in knee,positive grinding test of patella,McMurray sign,fricative,muscular atrophy of quadriceps femoris,and stretch or flexion limita-tion.X-ray abnormalities were found as follows in decreasing freguency:bony hyperplasia,articular facet sclero-sis,osteoporosis,uneven articular surface,narrowing of joint space and loose bodies.Arthroscopical findings were as follows:synovial congestion and proliferation,hypertrophy or entrapment of fat pad,osteophyte,syn-ovial fold entrapment,stripping of cartilage,meniscal lesions,subchondral bone exposure,anterior cruciate lig-ament friction or obstruction,and loose bodies.The common diseases that liable to misdiagnosis preoperatively were synovial chondroma,anterior cruciate ligament impingement syndrome and meniscal lesions.The rate of excellent and good results after arthroscopic treatment was86.6%.Conclusion Hypertrophy and entrapment of fat pad,thickening and entrapment of synovial fold,stripping of cartilage,meniscal lesions,anterior cruciate ligament friction or obstruction,and loose bodies are the key factors that cause knee dysfunction in OA.The arthroscopic treatment is an effective supplement in treating knee OA.