Objective:To explore the effect of phased nursing based on the compliance curve in pelvic floor function rehabilitation training for patients with stress urinary incontinence.Methods:From January 2019 to June 2020, convenience sampling was used to select 70 patients with stress urinary incontinence in the Urology Surgery, the Second Affiliated Hospital of Zhejiang Chinese Medical University as the research object. Patients were randomly divided into the control group and the intervention group with the random number table method, each with 35 cases. The control group conducted conventional nursing, and the intervention group carried out phased nursing based on the compliance curve on this basis. The treatment effects of the two groups after intervention were compared, and the self-efficacy and quality of life of the two groups of patients before and after the intervention were compared through the Pelvic Floor Muscle Training Self-Efficacy Scale and the Incontinence Quality of Life Questionnaire (I-QOL) .Results:After the intervention, the treatment effect of the intervention group was better than that of the control group, and the difference was statistically significant ( P<0.05) . After the intervention, the self-efficacy score of patients in the intervention group was (1 328.8±276.8) , which was higher than that (1 150.5±324.8) of the control group, and the difference was statistically significant ( P<0.05) . After the intervention, the total score and the scores of each dimension of the I-QOL of the intervention group were higher than those of the control group, and the differences were statistically significant (all P<0.05) . Conclusions:The phased nursing based on the compliance curve applied to the pelvic floor function rehabilitation training for patients with stress urinary incontinence can improve the treatment effect, self-efficacy and quality of life of the patients.

OBJECTIVETo investigate the association of the expressions of angiopoietin-2 (Ang-2), vascular endothelial growth factor (VEGF) in colorectal cancer tissues with Dukes' clinicopathological features.

METHODSAng-2 and Tie-2 mRNA expressions were detected in colorectal cancer tissues, adjacent tissues, and normal tissues by real time-PCR. Quantikine immunoassays were used to measure the protein expressions of Ang-2 and VEGF in the tissues and serum samples.

RESULTSAng-2 and Tie-2 levels were significantly higher in the serum of the patients than in the normal tissues (P<0.05), and their expressions were strongly correlated (r=0.879, P=0.000). Tumor tissue Ang-2 and VEGF levels were significantly higher than their levels in the adjacent and normal tissues (P<0.05). In colorectal cancer patients, the peripheral blood level of Ang-2 was significantly higher than that in healthy control subjects, and comparable with that in mesenteric blood (P>0.05). In Dukes' stage C and D patients, serum Ang-2 and VEGF levels were significantly higher than those in patients in Dukes' stage A and B (P<0.05).

CONCLUSIONAng-2 and VEGF over expressions may play an important role in the occurrence and progression of colorectal cancer.

Adult ; Aged ; Angiopoietin-2 ; blood ; metabolism ; Case-Control Studies ; Colorectal Neoplasms ; blood supply ; metabolism ; pathology ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Neovascularization, Pathologic ; Vascular Endothelial Growth Factor A ; blood ; metabolism