1.Effects of Ginsenoside Re on MDA Content and SOD Activity in Rats with Exercise-induced Fatigue
Yichong FENG ; Ziming ZHAO ; Yuan CHEN ; Huashan PAN ; Jiahong LI ; Bogao BIAN ; Xi WEN
Traditional Chinese Drug Research & Clinical Pharmacology 2000;0(06):-
Objective This report describes the mechanism of Ginsenoside Re to resist Exercise-induced fatigue based on the observation of effects on MDA content and SOD activity.Methods Thirty male SD rats were divided into 3 groups randomly:Ginsenoside Re group,model group and control group,10 rats in each group.Rats in Ginsenoside Re group were given gastric gavage of Ginsenoside Re once a day,while rats in model and control groups were given the same volume of normal saline.One hour after administration,rats of Ginsenoside Re groups and Model groups received medium-intensity treadmill exercise for 20 minutes at the speed of 15m/min,with a slope of 0 degree,and after 40-mimute break repeated it for another 20minutes.Fourteen days later,MDA content and SOD activity have been tested.Results MDA content in the serum,liver tissue and muscle tissue of Ginsenoside Re group was obviously lower than that in the model group (P
3.Investigation of the role of HIF-1α and VEGF in women with missed abortion
Yanli LI ; Lili YANG ; Han GAO ; Yichong YUAN ; Faxia ZHU ; Bin YAN ; Xufeng WU
China Modern Doctor 2014;(35):127-129,132
Objective To investigate the association of HIF-1αand VEGF signaling in missed abortion. Methods Fifty patients with missed abortion were selected as study group, and fifty early pregnant women who underwent artificial abortion surgery were selected as control group. The expressions of HIF-1α and VEGF were measured by immunohis-tochemistry. Results The expressive rate of VEGF was 100%in the control group and 66% in the study group. The ex-pressive rate of HIF-1α was 42% in the control group and 76% in the study group. Compared with the control group, the expression of VEGF was statistically reduced(P<0.05) while the level of HIF-1α was significantly up-regulated(P<0.05)in the study group. In the control group, HIF-1αwas positively correlated with VEGF(r=0.387,P<0.05), while in the study group HIF-1α was close negatively correlated with VEGF(r=-0.298,P>0.05). Conclusion The decrease of VEGF and increase of HIF-1αin villous trophoblastic cells may be signals of occurrence of missed abortion.