Objective To investigate the efficacy of dexmedetomidine in reduce of hyperalgesia in patien with remifentanil anesthesia.Methods 84 patients scheduled for laparoscopic hysterectomy from December 2014 to April 2016 were selected and randomly divided into two groups: the observation group and the control group,42 cases in each group,two groups were intravenous infusion of remifentanil,propofol and inhaled sevoflurane to maintain anesthesia.In the observation group,0.6μg/kg of dexmedetomidine was given 40minutes before the end of the operation(adding to 100mL 0.9％sodium chloride solution,infusion within 10minutes),the control group was given the same volume of 0.9％sodium chloride solution.The visual analogue scale(VAS)and the bruggrmann comfort scale(BCS)were used to evaluate the postoperative pain and comfort of the two groups of patients at different time points,and compare the incidence of adverse events between the two groups.Results The VAS scores of the two groups were significantly different at 1h(T1),4h(T2)and 24h(T3),and the VAS score of the observation group was significant better than that of the control group,the difference was statistically significant(P<0.05),the BCS scores of two group were compared at T1 and T2,the difference was statistically significant(P<0.05),but there was no significant difference between the two groups at T3.The incidence of adverse reactions in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion Dexmedetomidine can relieve and prevent the incidence of hyperalgesia and adverse reactions in patients with remifentanil anesthesia,and improve the analgesic effect of postoperative patients.

Objective To investigate the role of sex chaperone on self-acceptance,anxiety,depression and coping strategy in stable phase extensive burn patients'.Methods According to the different role of accompanies,the extensive burn patients in stable phase were divided into sex chaperone accompany groups(treatment group)and non-sex chaperone accompany group(control group).They were assessed by self-acceptance questionnaire(SAQ),self-rating anxiety scale(SAS),self-rating depression scale(SDS)and medical coping modes questionnaire(MCMQ).The results were statistically analyzed.Results The treatment group patients'results are as follows:SAQ total score was(41.37±6.98),self-acceptance factor score was(20.56±4.87),self-evaluation factor score was(22.35±5.82),MCMQ facing factor score was(21.80±4.07),MCMQ avoiding factor score was(22.35±5.82).The results of treatment group patients were significantly higher than those in control group,it had significant differences(P<0.05 or P<0.01);while the treatment group patients'scores of SAS,SDS,MCMQ yield factor were significantly lower that those in the contorl group.The self-acceptance factor score appeared to be negative correlation with the SAS score,SDS score and MCMQ yield factor score,while to be positive correlation with MCMQ facing/avoiding factor score.Conclusion Sex chaperone'accompany can eliminate the extensive burn patients'tension and the effect of adverse psychological factors,and meet family love needs of patients,then improve the level of patient self-acceptance,reverse the negative emotion of patients,and guide patients in a positive way to face the disease.

The recent research progress of photo-catalyzed degradation of organic pollutants by TiO2 is reviewed,the characteristics of hydrothermal method and the prepared processes of TiO2 were discussed,the photo-catalyzed mechanism under UV and visible light and the application of degradation of sewage using TiO2 nanomaterials from five aspects were described in this paper. The main problems existing in the studies of TiO2,the research directions,and the development prospects were also discussed.

OBJECTIVE:To prepare diclofenac sodium controlled release tablet,and to evaluate the mechanism of drug release.METHODS:Stearic acid and ethyl cellulose were used as blocking agents and sodium carboxylmethyl starch was used as disintegrating agent.Tablets were made after drying the granules prepared.The dissolution rates were acquired according to Chinese Pharmacopoeia(1995).RESULTS:Drug release from the tablets prepared was of zero-order release before 90% of drug released.No significant influences were observed from the dissolution rates of the different pressure of tablet(5～10kg),amount of drugs contained in the tablet(35%～60%)and different geometry of the tablets,respectively.The remarkable difference waw observed between the disintegrating and blocking agents contained in the tablets.CONCLUSION:The time of 50% of durg released could be changed as the amount of disintegrating or blocking agents were changed.

Objective To develop the neonatal hearing screening,investigate the incidence and relevant high-risk factors of congenital hearing loss,and explore feasible methods of early screening,diagnosis,following-up and intervention.Methods DPOAE was used for the newborns.The children who failed the tests or had high-risk factors of hearing loss were re-screened using DPOAE and AABR 42 days.ABR was used as the diagnostic test for those who had abnormal results at 3 months,ABR and ASSR were used at 6 months for the second diagnosis.The children with hearing loss were intervened in time,and were arranged for routine following-up and audiological evaluation.Results The normal neonates who failed the first screening was 14.8%,infants with high-risk factors was 21.5%,the large number of normal infants passed re-screening and half of high-risk neonates failed.By analysis of patients who had three-month diagnosis,the incidence of congenital hearing loss was about 2.75‰,and mild-grade,middle-grade,severe,profound was 0.18‰,1.78‰,0.26‰ and 0.53‰ respectively.Conclusion The incidence of congenital hearing loss is the highest in congenital diseases,usual screening is necessary.Questionnaire for high-risk factors of hearing loss must be done;it is very important to follow-up the abnormal infants.

Objective To detect the presence of DEK protein in the tissue and voided urine of patients with bladder urothelial carcinoma ,and an?alyze the relationship between DEK protein and clinical pathological classification of bladder cancer. Methods The expression of DEK protein was examined by immunohistochemistry in 48 bladder cancer tissues and 18 adjacent normal tissues(control group). The presence of DEK protein in voided urine was analyzed by western blot in 28 bladder cancer patients and 6 healthy individuals(control group). Results The positive ex?pression of DEK protein in bladder tumor tissues(73%)is higher than in adjacent normal tissues(33%,P<0.05). The expression of DEK in su?perficial bladder cancer(86%)was found higher than invasive bladder cancer(55%)with significant differences(P<0.05). The expression of DEK in urine samples of bladder cancer patients(0.834)was found higher than control group(0.242,P<0.05);Compared with the DEK expres?sion of control group,the sensitivity of diagnosis of bladder cancer with voided urine could be 82.1%. Conclusion DEK protein positive ex?pressed in tissues and voided urine of patients with bladder urothelial carcinoma. The expression was correlated with pathological classification of bladder cancer. The positive rate of DEK expression in early stage of tumor tissues is higher than late stage. The presence of DEK protein in tissues and voided urine can be considered as a suitable biomarker for bladder cancer potentially.

Objective To analyze the incidence of hospital-acquired infection and the distribution of pathogens through data from the hospital infection surveillance networks in Shandong. Methods A meta-analysis was made of the data submitted by the hospitals involved in the provincial surveillance networks from August 2001 to July 2004. Results The surveillance data involved 1 776 030 hospitalized patients, of whom 43 355 had a hospital-acquired infection, the incidence of hospital-acquired infection being 2.44‰. Respiratory-tract infections were most frequent, followed by gastroenteric-tract infections, urinary-tract infections and surgical-site infections. A total of 6 251 strains of pathogens were isolated, the most commonly identified pathogens being Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Klebsiella pneumoniae, Candida albicans and Staphylococcus epidermidis. Conclusion It is imperative to reinforce the sterilization of air and medical instruments, strictly abide by aseptic manipulation, and promote the rational use of antimicrobials. Hospital infection surveillance ought to be conducted by the combined method of prevalence surveys and the targeted surveillance of key sectors.

Objective To assess the adequacy of decompression immediately in anterior cervical surgical procedures with epidurography, and to prevent from leaving compressive materials. Methods After completing primary decompression of anterior cervical intervertebral space by discectomy or corpectomy, posterior longitudinal ligaments were incised or resected, 5-10 ml Omnipaque 300 contrast medium was injected into upper and lower segments of decompressed area through a soft 18# injection needle. Distribution of the contrast medium in front of dura mater was observed by fluoroscopy so as to identify whether the spinal cords were decompressed completely. 64 patients suffered from cervical spondylotic myelopathy, and spinal cords were compressed respectively by giant intervertebral disc prolapse, osteophyte or short segmental OPLL. Intraoperative epidurography was performed after primary anterior decompression. If contrast medium in front of dura mater was discontinued by fluoroscopy, incomplete decompression was judged. 39 of 64 patients were followed up after operation, and in 18 patients of them MRI were taken within 1-12 weeks after operation. Neurological function was compared between preoperation, immediate postoperation and final follow-up by means of JOA scores. Results After completing primary decompression, epidurographs showed that the contrast medium were continuous in front of dura mater in 49 cases(77%), 11 patients of them were examined by MRI during follow-up and the images indicated that cervical cords were free of compression. In 15 cases (23%), the contrast medium was not continuous in front of dura mater, then decompression was performed further until the contrast medium no any interruption. 7 patients of them were confirmed by MRI that cervical cords were no more compressed. 39 patients were followed up postoperatively with a mean follow-up of 13 months. Neurological function was recovered immediately after operation by 52% and 61% at final follow-up. No neurological deficit progressed in all of them. Conclusion Intraoperative epidurography is effective and safe for assessment of decompression during anterior cervical surgical procedures.

Objective To explore the pathogenic effect of serum platelet derived growth factor(PDGF) in Henoch - Schonlein pur-pura nephritis(HSPN) and the influence of heparin. Methods The levels of serum PDGF were detected before and after heparin therapy by double antibody ELISA in the peripheral blood of patients. All patients were injected with heparin calcium[100 U/(kg?d)] for two to three weeks. Results The levels of serum PDGF(596.23 ? 199.43) ng/L in 30 HSPN cases before heparin therapy were significantly higher than those of the control group(259.76?69.58) ng/L (P

Field cabin,a new generation of our military medical support system,was used in the Wenchuan Earthquake relief for the first time. The ordonnance and features of X-ray field cabin were also laid out. In Mianyang city,within 86 days,there were 710 wounded persons were checked up,and the rate of high quality photo was up to 85%. The rational ordonnance,steady performance,easily deployed and withdrawn features of the X-ray field cabin ensure it adapted to long-distance medical support and fulfill its mission effectively. However,some disadvantages of it are also found in the application,and innovating proposal is further introduced.